Integrated Family-Based Treatment of Co-Occurring Adolescent SUD and ADHD

对同时发生的青少年 SUD 和 ADHD 的综合家庭治疗

• 批准号: 8411991
• 负责人: Aaron Hogue
• 金额: $ 12.52万
• 依托单位: PARTNERSHIP TO END ADDICTION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8411991
• 关键词: Adherence; Adolescence; Adolescent; Archives; Area; Attention deficit hyperactivity disorder; Behavior Therapy; Behavioral; Behavioral Symptoms; Brain; Caregivers; Clinic; Clinical; Communities; Competence; Conflict (Psychology); Data; Decision Making; Development; Discipline; Disease; Effectiveness; Esthesia; Experimental Designs; Family; Family psychotherapy; Foundations; Functional Magnetic Resonance Imaging; Future; Geographic Locations; Goals; Impulsivity; Intervention; Lead; Learning; Maintenance; Measures; Modeling; Monitor; Outcome; Parenting behavior; Pharmaceutical Preparations; Pharmacological Treatment; Pilot Projects; Principal Investigator; Process; Protocols documentation; Psychiatrist; Psychopathology; Psychopharmacology; Psychotherapy; Randomized; Regimen; Regulation; Reporting; Research; Research Personnel; Risk Factors; Risk-Taking; Sampling; Schools; Services; Staging; Symptoms; Techniques; Testing; Training; Training Activity; Treatment outcome; adolescent substance use; anti social; base; career; career development; cohesion; design; efficacy trial; evidence base; experience; improved; neurodevelopment; neuroimaging; neuropsychological; psychologic; psychostimulant; public health relevance; satisfaction; service utilization; skills; therapy development; tool; treatment adherence; treatment as usual; treatment effect; treatment planning; treatment response

DESCRIPTION (provided by applicant): For adolescents with comorbid SUD and ADHD, integrated treatment models that combine behavioral and pharmacological interventions are urgently needed to achieve lasting clinical gains for both conditions. Dr. Hogue's expertise in family-based treatment for adolescent SUDs makes him an excellent candidate to become a productive investigator in this area. The objective of this amended K02 application is to provide Dr. Hogue with training and collaborative research experiences in three core areas: (1) Behavioral Intervention Core: training in developmental psychopathology and behavioral treatment for adolescent ADHD that includes treatment planning for school and learning problems; (2) Psychopharmacology Core: training in medication intervention and compliance issues for adolescent ADHD and other co-occurring disorders, and in the conduct of medication trials for adolescent disorders; (3) Neurodevelopment Core: training in neurodevelopmental risk factors associated with ASU and ADHD and in neuroimaging (fMRI) techniques for investigating brain processes and treatment response in adolescents with SUD/ADHD. Training in these core areas will lead to development of a new treatment for ASU/ADHD, Functional Family Therapy - Integrated Model (FFT-IM), an adapted version of an empirically based model for ASU that incorporates neuropsychological assessment and an evidence-based psychostimulant medication protocol for ADHD. Training activities will culminate in a Stage I pilot study of FFT-IM involving N = 20 adolescents with SUD/ADHD. This Stage Ia pilot study of FFT-IM is designed to yield proof-of-concept data with regard to feasibility and acceptability, treatment fidelity, and effect size estimates for behavioral, developmental, and family outcomes. The quasi-experimental design will compare service utilization effects and posttreatment outcomes in 20 FFT-IM cases versus 20 TAU matched comparison cases drawn from the same geographic area who receive routine services in community clinics. Observational fidelity tools will be developed for newly developed FFT-IM components and used to evaluate adherence and competence in the pilot cases. If promising, study results would set the foundation for a randomized efficacy trial of FFT-IM.

描述（由申请人提供）：对于患有 SUD 和 ADHD 共病的青少年，迫切需要结合行为和药物干预的综合治疗模型，以实现这两种疾病的持久临床获益。 Hogue 博士在青少年 SUD 家庭治疗方面的专业知识使他成为该领域富有成效的研究者的优秀候选人。修订后的 K02 申请的目的是为霍格博士提供三个核心领域的培训和合作研究经验：(1) 行为干预核心：青少年多动症的发展精神病理学和行为治疗培训，包括学校和学习问题的治疗计划; (2) 精神药理学核心：针对青少年多动症和其他并发疾病的药物干预和依从性问题的培训，以及针对青少年疾病进行药物试验的培训； (3) 神经发育核心：与 ASU 和 ADHD 相关的神经发育危险因素以及用于研究 SUD/ADHD 青少年的大脑过程和治疗反应的神经影像 (fMRI) 技术的培训。这些核心领域的培训将导致针对 ASU/ADHD 的新治疗方法的开发，即功能家庭治疗 - 综合模型 (FFT-IM)，这是 ASU 基于经验的模型的改编版本，结合了神经心理学评估和循证精神兴奋剂ADHD 的药物治疗方案。培训活动将在 FFT-IM 第一阶段试点研究中达到高潮，该研究涉及 N = 20 名患有 SUD/ADHD 的青少年。 FFT-IM 的 Ia 阶段试点研究旨在产生有关可行性和可接受性、治疗保真度以及行为、发育和家庭结果的效应大小估计的概念验证数据。准实验设计将比较 20 个 FFT-IM 病例与来自同一地理区域、在社区诊所接受常规服务的 20 个 TAU 匹配对照病例的服务利用效果和治疗后结果。将为新开发的 FFT-IM 组件开发观察保真度工具，并用于评估试点案例中的依从性和能力。如果有希望，研究结果将为 FFT-IM 的随机疗效试验奠定基础。