Molecular Genetics of Basic Cell Functions

基本细胞功能的分子遗传学

• 批准号: 6747364
• 负责人: ABRAHAM Lincoln SONENSHEIN
• 金额: $ 19.59万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 1975
• 资助国家: 美国
• 起止时间: 1975-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6747364
• 关键词: Molecular; Genetics; Basic; Cell; Functions

DESCRIPTION (provided by applicant): Continued support is requested for an interdepartmental training program in genetics of basic cell functions. The emphasis is on rigorous training focused on studies of basic cell processes, such as chromosome replication and segregation, cell growth and division, regulation of gene expression, cellular differentiation, and host-parasite interactions. This training program has been the beneficiary of continuous support from NIGMS since 1975. In the present application, support is requested for six predoctoral trainees per year for a period of five years. The 19 members of the training faculty are from the Departments of Molecular Biology and Microbiology, Biochemistry, Pathology, Dermatology, and Medicine. They are highly interactive and dedicated to close, joint supervision and mentoring of graduate students. Their laboratories are fully equipped for modern molecular genetics research and have direct access to more sophisticated equipment in shared facilities. Past trainees include leading researchers in academia and industry. The training program is administered by the Graduate Program in Molecular Microbiology of the Sackler School of Graduate Biomedical Sciences. Starting with a pool of about 140 applicants, the graduate program annually admits 7-8 new students, of whom 70-80% are typically eligible for training grant support. The program has been successful in attracting an unusual number of students from underrepresented minority groups, all of whom have been supported by this training grant. Of the 167 students admitted since the inception of the graduate program in 1964, 108 have graduated with the Ph.D. degree and 9 with the MS degree. Forty-one students are currently in training. Seven of the current students are from underrepresented minority groups. Nearly all graduates of the program have obtained high-quality postdoctoral appointments and are still active as researchers, as teachers, or in allied fields. Entering students take required courses in Genetic Analysis and Biochemistry and pursue 9-week rotation projects in four different laboratories. At the end of the first academic year, they choose a thesis supervisor and begin thesis research. Student progress during the first year is monitored closely by the faculty as a whole and thereafter by the thesis advisory committee. In the second and third years, the students complete required and elective coursework and prepare a research proposal (unrelated to their thesis topic) as a Ph.D. qualifying examination. All students are required to complete a seminar course in scientific ethics.

描述（由申请人提供）：请求持续支持 基本细胞功能遗传学的部门间培训计划。这 重点是严格的培训，重点是基本细胞过程的研究， 例如染色体复制和隔离，细胞生长和分裂， 调节基因表达，细胞分化和宿主 - 寄生虫 互动。该培训计划一直是连续的受益者 自1975年以来的奈克（Nigms）支持。在本申请中，请求支持 每年六年的六名学员五年。 19 培训教师的成员来自分子生物学系 以及微生物学，生物化学，病理学，皮肤病学和医学。他们是 高度互动，致力于关闭，共同监督和指导 研究生。他们的实验室配备了现代分子的设备齐全 遗传学研究并可以直接访问更复杂的设备 共享设施。过去的学员包括学术界的主要研究人员 行业。 培训计划由分子研究生计划管理 萨克勒研究生生物医学科学学院的微生物学。开始 该研究生课程每年有大约140名申请人的库，每年7-8岁 新生，其中70-80％的学生通常有资格获得培训赠款支持。 该计划已经成功吸引了不寻常的学生 来自代表性不足的少数群体，所有这些群体都得到了支持 培训补助金。自从成立以来，在167名学生中 1964年的研究生课程，有108位毕业于博士学位。学位和9 MS学位。目前有41名学生正在接受培训。七个 目前的学生来自代表性不足的少数群体。几乎全部 该计划的毕业生已获得高质量的博士后预约 并且仍然活跃于研究人员，教师或盟军领域。 进入学生参加遗传分析和生物化学的必需课程 并在四个不同的实验室中进行9周的轮换项目。在最后 在第一个学年，他们选择论文主管并开始论文 研究。第一年的学生进步由 整个教职员工，此后由论文咨询委员会委员会。在 第二年和第三年，学生完成并选择课程 并准备研究建议（与他们的论文主题无关）作为博士学位。 合格考试。所有学生都必须完成研讨会课程 在科学伦理学中。