Administrative Core

行政核心

• 批准号: 8848939
• 负责人: Hugh A Sampson
• 金额: $ 1.62万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8848939
• 关键词: 3 year old; 6 year old; Accounting; Adult; Advisory Committees; Affect; Allergic; Allergic Disease; Allergic rhinitis; Allergy to peanuts; American; Asthma; Atopic Dermatitis; Birth Rate; Cattle; Child; Clinical; Communication; Consultations; Country; Databases; Developed Countries; Disease; Equipment; Food; Food Hypersensitivity; Future; Goals; Human Resources; Hypersensitivity; IgE; Immunologics; Immunotherapy; Infant; Life; Measures; Mediating; Methods; Milk; Milk Hypersensitivity; Monitor; National Institute of Allergy and Infectious Disease; Nuts; Procedures; Process; Reporting; Research; Research Design; Resources; Review Committee; Seafood; Services; Teleconferences; Therapeutic; Travel; Trees; United States National Center for Health Statistics; Vertebral column; Work; base; data sharing; experience; immunopathology; meetings; member; prevent; prophylactic

Food allergy affects over 11 million Americans and is most prevalent in young children, with 6% - 8% of children less than 3 years of age experiencing some form of food hypersensitivty. Milk allergy is the most common cause of food hypersensitivity in infants and young children, typically develops in the first year of life, affects 2.5% of infants in industrialized countries, and is "outgrown" in about 80% of children by 6 years of age. IgE-mediated allergy accounts for about 70% of milk allergic disorders, i.e. 1.8% of young infants, and often is a harbinger of future atopic disorders and other food allergies. Despite an increased understanding of IgE-mediated immunopathology, no successful therapeutic measures have been developed to prevent or reverse food allergies. The overall goal of this Center is to elucidate further underlying immunologic mechanisms of milk allergy and to develop safe and effective forms of therapy. The Administrative Core will facilitate this effort by providing the organizational backbone for this Center, monitoring clincal trials, providing biostatistical support for all projects, and coordinating interactions within and outside the Center, e.g. NIAID, other AADCR Centers and the external Scientific Review Committee. This wll be achieved through the following Specific Aims: Aim #1: Facilitate communication and interaction between Projects 1-3, assist in subject recruitment and retention, and provide clinical monitoring, database support and biostatistical support for all projects. Aim #2: Implement an external Scientific Review Committee with independent experts in the field of food allergy and immunotherapy. Aim #3: Provide mechanisms for communicating with other members of the AADCR Centers. Aim #4: Oversee resource and data sharing between this project and other members of the AADCR Centers. The Administrative Core will provide manegerial support, organizational support for monthly internal project review meetings, quarterly inter-project meetings of Pi's and key personnel, quarterly AADCRC Steering Committee teleconferences, bienniel Scientific Advisory Committee teleconferences, and annual AADCRC PI meetings in Bethesda. The Core will arrange lodging [if nececessary; e.g. external reviewers], meeting rooms and equipment for meetings held at Mount Sinai, and process travel expense reports for reimbursement to scientific and PI annual meetings. The Core will also work with the AADCRC Steering Committee to promote the sharing of data collected as a part of this proposal and of methods, procedures and resources developed in support of this proposal with other members of the AADCRC network.

食物过敏会影响超过1100万美国人，在幼儿中最普遍，其中6％ - 8％ 不到3岁的儿童经历某种形式的食物超敏。牛奶过敏是最大的 婴儿和幼儿食物过敏的常见原因通常在第一年的第一年发展 生活影响2.5％的工业化国家婴儿，大约80％的儿童在6岁时“长大” 年龄。 IgE介导的过敏量约为70％的牛奶过敏性疾病，即1.8％的年轻婴儿 通常是未来特应性疾病和其他食物过敏的预兆。尽管增加了 了解IgE介导的免疫病理学，没有成功的治疗措施是 开发以防止或逆转食物过敏。该中心的总体目标是进一步阐明 牛奶过敏的潜在免疫机制，并开发出安全有效的治疗形式。 行政核心将通过为该中心提供组织骨干来促进这项工作， 监视金质试验，为所有项目提供生物统计学支持，并协调互动 以及中心外，例如NIAID，其他AADCR中心和外部科学审查委员会。 通过以下特定目的实现这一目标： 目的＃1：促进项目1-3之间的沟通和互动，协助主题招聘和 保留，并为所有项目提供临床监测，数据库支持和生物统计支持。 目标＃2：与食品领域的独立专家实施外部科学审查委员会 过敏和免疫疗法。 AIM＃3：提供与AADCR中心其他成员交流的机制。 目标＃4：监督该项目与AADCR中心其他成员之间的资源和数据共享。 行政核心将为每月内部的内部支持，组织支持，组织支持 项目审查会议，PI的季度项目间会议和关键人员，季度AADCRC 指导委员会电视会议，Bienniel科学咨询委员会电视会议和年度 AADCRC PI会议在贝塞斯达举行。核心将安排住宿[如果必要的话；例如外部评论者]， 会议室和设备，用于在西奈山举行的会议，并处理旅行费用报告 报销科学和PI年度会议。核心也将与AADCRC转向一起使用 促进作为本提案的一部分和方法的一部分收集的数据共享的委员会 以及与AADCRC网络其他成员一起支持该提案的资源。