Administrative Core

行政核心

• 批准号: 8848939
• 负责人: Hugh A Sampson
• 金额: $ 1.62万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8848939
• 关键词: 3 year old; 6 year old; Accounting; Adult; Advisory Committees; Affect; Allergic; Allergic Disease; Allergic rhinitis; Allergy to peanuts; American; Asthma; Atopic Dermatitis; Birth Rate; Cattle; Child; Clinical; Communication; Consultations; Country; Databases; Developed Countries; Disease; Equipment; Food; Food Hypersensitivity; Future; Goals; Human Resources; Hypersensitivity; IgE; Immunologics; Immunotherapy; Infant; Life; Measures; Mediating; Methods; Milk; Milk Hypersensitivity; Monitor; National Institute of Allergy and Infectious Disease; Nuts; Procedures; Process; Reporting; Research; Research Design; Resources; Review Committee; Seafood; Services; Teleconferences; Therapeutic; Travel; Trees; United States National Center for Health Statistics; Vertebral column; Work; base; data sharing; experience; immunopathology; meetings; member; prevent; prophylactic

Food allergy affects over 11 million Americans and is most prevalent in young children, with 6% - 8% of children less than 3 years of age experiencing some form of food hypersensitivty. Milk allergy is the most common cause of food hypersensitivity in infants and young children, typically develops in the first year of life, affects 2.5% of infants in industrialized countries, and is "outgrown" in about 80% of children by 6 years of age. IgE-mediated allergy accounts for about 70% of milk allergic disorders, i.e. 1.8% of young infants, and often is a harbinger of future atopic disorders and other food allergies. Despite an increased understanding of IgE-mediated immunopathology, no successful therapeutic measures have been developed to prevent or reverse food allergies. The overall goal of this Center is to elucidate further underlying immunologic mechanisms of milk allergy and to develop safe and effective forms of therapy. The Administrative Core will facilitate this effort by providing the organizational backbone for this Center, monitoring clincal trials, providing biostatistical support for all projects, and coordinating interactions within and outside the Center, e.g. NIAID, other AADCR Centers and the external Scientific Review Committee. This wll be achieved through the following Specific Aims: Aim #1: Facilitate communication and interaction between Projects 1-3, assist in subject recruitment and retention, and provide clinical monitoring, database support and biostatistical support for all projects. Aim #2: Implement an external Scientific Review Committee with independent experts in the field of food allergy and immunotherapy. Aim #3: Provide mechanisms for communicating with other members of the AADCR Centers. Aim #4: Oversee resource and data sharing between this project and other members of the AADCR Centers. The Administrative Core will provide manegerial support, organizational support for monthly internal project review meetings, quarterly inter-project meetings of Pi's and key personnel, quarterly AADCRC Steering Committee teleconferences, bienniel Scientific Advisory Committee teleconferences, and annual AADCRC PI meetings in Bethesda. The Core will arrange lodging [if nececessary; e.g. external reviewers], meeting rooms and equipment for meetings held at Mount Sinai, and process travel expense reports for reimbursement to scientific and PI annual meetings. The Core will also work with the AADCRC Steering Committee to promote the sharing of data collected as a part of this proposal and of methods, procedures and resources developed in support of this proposal with other members of the AADCRC network.

食物过敏影响超过 1100 万美国人，其中幼儿最为常见，占 6% - 8% 患有某种形式的食物过敏的 3 岁以下儿童。牛奶过敏最严重 婴儿和幼儿食物过敏的常见原因，通常发生在出生后的第一年 生活中，影响工业化国家 2.5% 的婴儿，约 80% 的儿童到 6 岁时就会“长大” 的年龄。 IgE 介导的过敏约占牛奶过敏性疾病的 70%，即小婴儿的 1.8%， 通常是未来特应性疾病和其他食物过敏的先兆。尽管增加了 对 IgE 介导的免疫病理学的了解，尚未有成功的治疗措施 旨在预防或逆转食物过敏。该中心的总体目标是进一步阐明 牛奶过敏的潜在免疫机制并开发安全有效的治疗形式。 行政核心将通过为该中心提供组织支柱来促进这项工作， 监测临床试验，为所有项目提供生物统计支持，并协调内部互动 以及中心外，例如NIAID、其他 AADCR 中心和外部科学审查委员会。 这将通过以下具体目标来实现： 目标#1：促进项目 1-3 之间的沟通和互动，协助受试者招募和 保留，并为所有项目提供临床监测、数据库支持和生物统计支持。 目标#2：建立一个由食品领域独立专家组成的外部科学审查委员会 过敏和免疫治疗。 目标#3：提供与 AADCR 中心其他成员沟通的机制。 目标 4：监督该项目与 AADCR 中心其他成员之间的资源和数据共享。 行政核心将为每月的内部活动提供管理支持和组织支持 项目审查会议、Pi 和关键人员的季度项目间会议、季度 AADCRC 指导委员会电话会议、两年期科学咨询委员会电话会议和年度会议 AADCRC PI 在贝塞斯达举行的会议。核心将安排住宿[如果需要；例如外部评审员], 在西奈山举行会议的会议室和设备，并处理会议的差旅费用报告 科学和 PI 年度会议的报销。该核心还将与 AADCRC Steering 配合使用 委员会促进作为本提案一部分收集的数据以及方法、程序的共享 以及与 AADCRC 网络其他成员一起支持该提案而开发的资源。