Extensibility of Rotator Cuff Muscle with Tendon Rupture Determined Using SWE

使用 SWE 确定肌腱断裂时肩袖肌肉的伸展性

• 批准号: 8616453
• 负责人: KAI-NAN AN
• 金额: $ 20.99万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8616453
• 关键词: Adopted; Area; Cadaver; Clinical; Debridement; Defect; Development; Elderly; Evaluation; Failure; Future; Goals; Image; In Vitro; Individual; Injury; Investigation; Joint structure of shoulder region; Lead; Left; Length; Measurement; Measures; Mechanics; Minor; Monitor; Muscle; Muscle Fibers; Nature; Operative Surgical Procedures; Orthopedics; Outcome; Physiological; Procedures; Process; Property; Recovery; Regression Analysis; Rehabilitation therapy; Replacement Arthroplasty; Rotator Cuff; Rupture; Severities; Shoulder; Shoulder Pain; Site; Specimen; Speed; Stretching; Surgeon; Techniques; Tendon Injuries; Tendon Transfer; Tendon structure; Testing; Time; Tissues; Treatment outcome; Ultrasonography; Variant; Viscosity; base; disability; elastography; imaging modality; improved; in vivo; injured; innovation; interest; new technology; outcome forecast; public health relevance; repaired; sound; supraspinatus muscle; tool

PROJECT SUMMARY/ABSTRACT Rotator cuff tears are the most common cause of shoulder pain and related disability. Likelihood of injury increases dramatically with advancing age. Over time following injury, the tendon retracts, leaving a large defect. However, not only is the tissue gap a problem, but also the nature of the muscle changes, with an end result of decreased compliance and increased stiffness. Though it is clear that the tension required for repair increases with time after injury, there is much individual variation. Thus, it is critical to have an individualized pre-surgical prediction of extensibility of rotator cuff muscles assist in pre-surgical planning and monitoring of recovery throughout the rehabilitation process. Our long-term goal is to develop a non-invasive tool for acquiring such information to improve the planning, and thus, the outcome of treatment. The purpose of this study is to initiate the development by adopting a novel technology, namely, Shear Wave Elastography (SWE). The SWE provides quantitative in vivo measurements of tissue stiffness and viscosity by evaluating shear wave propagation speed, which is inherently related to tissue mechanical properties. We propose this unique and innovative approach which combines b-mode ultrasound imaging (to assess muscle geometric and morphological properties) with SWE (to assess muscle material properties) to quantify muscle structural properties which will then be used to predict the extensibility of rotator cuff muscles (typically supraspinatus muscle). The objective of this study will be accomplished in the following three specific aims using cadaver shoulder specimens in vitro: Specific Aim 1: To obtain the material and geometric properties of the supraspinatus muscles using SWE and b-mode ultrasound imaging, respectively. Specific Aim 2: To measure muscle extensibility and structural properties of the supraspinatus muscles through mechanical testing. Specific Aim 3: To establish the relationship between structural stiffness of in vitro supraspinatus muscles (measured in Specific Aim 2) with muscle modulus measured with SWE and geometric/morphological properties based on b-mode imaging (measurements in aim 1) via regression analyses. The contribution will be significant because it will provide a necessary, non-invasive assessment of whole-tissue extensibility that will directly aid in prognosis, pre-surgical planning, and post-surgical evaluation of rotator cuff repair, one of the most common and challenging procedures in orthopedics.

项目摘要/摘要 肩袖撕裂是肩痛和相关残疾的最常见原因。可能性 随着年龄的增长，伤害大大增加。随着受伤后的时间，肌腱缩回， 留下很大的缺陷。但是，不仅组织间隙是一个问题，而且是 肌肉变化，最终导致依从性和刚度增加。虽然是 清楚地，维修所需的张力随着受伤后的时间而增加，有很多个人 变化。因此，对旋转器的扩展性进行个性化的术前预测至关重 袖口肌肉有助于手术前的计划和监测整个康复的恢复 过程。我们的长期目标是开发一种非侵入性工具，以获取此类信息 改善计划，从而改善治疗结果。这项研究的目的是启动 通过采用一种新型技术，即剪切波弹性图（SWE）开发。 SWE 通过评估剪切波，提供组织刚度和粘度的体内测量 传播速度与组织机械性能固有地相关。我们提出了这个 结合B模式超声成像的独特而创新的方法（评估肌肉 几何和形态特性）具有SWE（评估肌肉材料特性）以量化 肌肉结构特性将用于预测肩袖肌肉的扩展性 （通常是肌肉上肌）。这项研究的目的将在以下完成 在体外使用尸体肩部标本的三个特定目的：特定目的1：获得材料 使用SWE和B模式超声成像的肌上肌上肌的几何特性， 分别。特定目的2：测量肌肉的可扩展性和结构特性 肌上肌肉通过机械测试。特定目标3：建立关系 在体外肌肉肌肉的结构刚度（在特定目标2中测量） 基于B模式的SWE和几何/形态学特性测量的肌肉模量 成像（AIM 1中的测量）通过回归分析。贡献将是重要的 因为它将对全组织可扩展性提供必要的，无创的评估 直接帮助预后，手术前计划和肩袖修复后手术后评估，一个 骨科中最常见和最具挑战性的程序。