SKELETAL MUSCLE BY MR ELASTOGRAPHY

通过 MR 弹性成像检测骨骼肌

• 批准号: 2851807
• 负责人: KAI-NAN AN
• 金额: $ 21.55万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2851807
• 关键词: bioimaging /biomedical imaging; biomechanics; biomedical equipment development; clinical research; diagnosis design /evaluation; elasticity; human subject; image processing; magnetic resonance imaging; method development; muscle disorder diagnosis; muscle tension; noninvasive diagnosis; striated muscles

Numerous studies have to better understand the morphology and physiology of muscle and the etiology of injury and associated disorders. Interactions between the active force generator, passive force transmission, and the connective tissue are complicated and need to be further investigated. A newly developed technology, the Magnetic Resonance Elastography (MRE), provides great potential for in vivo investigation non- invasively. MRE images the response of tissue to acoustic shear waves to determine the shear modulus as well as the tension in the muscle. The specific aims of this study are: Aim 1: To Develop Practical Methods for Imaging Acoustic Shear Waves in Skeletal Muscle under Varied Loading Conditions: Develop electromechanical drivers and support devices that are designed specifically for applying shear waves to skeletal muscle. Develop a multislice version of the MRE pulse sequence with 3 axes of motion encoding, suitable for imaging shear waves in skeletal muscle over large fields of view. Develop a 3D acquisition sequence with similar capabilities. Evaluate various approaches for reducing acquisition time. Design and fabricate an MRI-compatable muscle loading system. Aim 2: To Develop Image Analysis Methods for MR Elastography of Skeletal Muscle: Develop and test several different approaches for measuring local wavelength in MRE images. Incorporate adjustments in the algorithms to accommodate waveguide phenomena that have been observed in preliminary studies. Develop methods for using MRI- derived muscle volumetric information to estimate regional fiber tension. Aim 3: To Utilize Magnetic Resonance Elastography to Study Normal Muscle In Vivo: The MRE technique will be applied in vivo to provide elastographic images of the muscles in the extremity of volunteers. Basic characteristics of muscle that include the moduli or stiffness of muscles as a function of the tension, the loading rate and the frequency of perturbation will be validated. Uniformity of tension distribution within the muscle will also be examined. Aim 4: To Utilize Magnetic Resonance Elastography to Study Abnormal Muscle In Vivo: The MRE technique will be applied in vivo to provide elastographic images of abnormal muscle, with known disorders to differentiate the physiology of normal and diseased muscle. Successful application of this technique will provide a means for assessing efficacy of various rehabilitation procedures.

许多研究必须更好地了解肌肉的形态和生理学以及损伤和相关疾病的病因学。 主动力发生器、被动力传递和结缔组织之间的相互作用很复杂，需要进一步研究。 新开发的技术，磁共振弹性成像（MRE），为体内非侵入性研究提供了巨大的潜力。 MRE 对组织对声剪切波的响应进行成像，以确定剪切模量以及肌肉张力。 本研究的具体目标是： 目标 1：开发在不同负载条件下对骨骼肌中声剪切波进行成像的实用方法：开发专门为将剪切波应用于骨骼肌而设计的机电驱动器和支撑装置。开发具有 3 个运动编码轴的 MRE 脉冲序列的多层版本，适用于在大视场内对骨骼肌中的剪切波进行成像。 开发具有类似功能的 3D 采集序列。 评估减少采集时间的各种方法。 设计和制造 MRI 兼容的肌肉加载系统。 目标 2：开发骨骼肌 MR 弹性成像的图像分析方法：开发和测试几种不同的方法来测量 MRE 图像中的局部波长。 在算法中进行调整，以适应在初步研究中观察到的波导现象。 开发使用 MRI 衍生的肌肉体积信息来估计区域纤维张力的方法。 目标 3：利用磁共振弹性成像研究体内正常肌肉：MRE 技术将应用于体内，提供志愿者四肢肌肉的弹性成像图像。 将验证肌肉的基本特征，包括作为张力、加载速率和扰动频率的函数的肌肉模量或硬度。 还将检查肌肉内张力分布的均匀性。 目标 4：利用磁共振弹性成像研究体内异常肌肉：MRE 技术将应用于体内提供异常肌肉的弹性成像图像，以及已知的疾病，以区分正常和患病肌肉的生理机能。该技术的成功应用将为评估各种康复程序的功效提供一种手段。