SKELETAL MUSCLE BY MR ELASTOGRAPHY

通过 MR 弹性成像检测骨骼肌

• 批准号: 2851807
• 负责人: KAI-NAN AN
• 金额: $ 21.55万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2851807
• 关键词: bioimaging /biomedical imaging; biomechanics; biomedical equipment development; clinical research; diagnosis design /evaluation; elasticity; human subject; image processing; magnetic resonance imaging; method development; muscle disorder diagnosis; muscle tension; noninvasive diagnosis; striated muscles

Numerous studies have to better understand the morphology and physiology of muscle and the etiology of injury and associated disorders. Interactions between the active force generator, passive force transmission, and the connective tissue are complicated and need to be further investigated. A newly developed technology, the Magnetic Resonance Elastography (MRE), provides great potential for in vivo investigation non- invasively. MRE images the response of tissue to acoustic shear waves to determine the shear modulus as well as the tension in the muscle. The specific aims of this study are: Aim 1: To Develop Practical Methods for Imaging Acoustic Shear Waves in Skeletal Muscle under Varied Loading Conditions: Develop electromechanical drivers and support devices that are designed specifically for applying shear waves to skeletal muscle. Develop a multislice version of the MRE pulse sequence with 3 axes of motion encoding, suitable for imaging shear waves in skeletal muscle over large fields of view. Develop a 3D acquisition sequence with similar capabilities. Evaluate various approaches for reducing acquisition time. Design and fabricate an MRI-compatable muscle loading system. Aim 2: To Develop Image Analysis Methods for MR Elastography of Skeletal Muscle: Develop and test several different approaches for measuring local wavelength in MRE images. Incorporate adjustments in the algorithms to accommodate waveguide phenomena that have been observed in preliminary studies. Develop methods for using MRI- derived muscle volumetric information to estimate regional fiber tension. Aim 3: To Utilize Magnetic Resonance Elastography to Study Normal Muscle In Vivo: The MRE technique will be applied in vivo to provide elastographic images of the muscles in the extremity of volunteers. Basic characteristics of muscle that include the moduli or stiffness of muscles as a function of the tension, the loading rate and the frequency of perturbation will be validated. Uniformity of tension distribution within the muscle will also be examined. Aim 4: To Utilize Magnetic Resonance Elastography to Study Abnormal Muscle In Vivo: The MRE technique will be applied in vivo to provide elastographic images of abnormal muscle, with known disorders to differentiate the physiology of normal and diseased muscle. Successful application of this technique will provide a means for assessing efficacy of various rehabilitation procedures.

许多研究必须更好地了解肌肉的形态和生理学以及损伤和相关疾病的病因。 主动力发生器，被动力传播和结缔组织之间的相互作用很复杂，需要进一步研究。 一种新开发的技术，即磁共振弹性图（MRE），为体内非侵入性研究提供了巨大的潜力。 MRE图像组织对声波的响应，以确定剪切模量以及肌肉的张力。 这项研究的具体目的是：目标1：开发实用方法，用于在各种负载条件下成像骨骼肌中的声学剪切波：开发机电驱动因素和支撑设备，这些驱动器和支持设备专门用于将剪切波应用于骨骼肌。使用3个运动编码轴开发MRE脉冲序列的多层版本，适用于大型视野上骨骼肌中的剪切波成像。 开发具有类似功能的3D采集序列。 评估各种减少获取时间的方法。 设计和制造具有MRI兼容的肌肉加载系统。 目标2：开发骨骼肌MR弹性学的图像分析方法：开发和测试几种测量MRE图像中局部波长的方法。 将调整纳入算法中，以适应初步研究中观察到的波导现象。 开发用于使用MRI-surem suscle量信息来估计区域纤维张力的方法。 AIM 3：利用磁共振弹性图在体内研究正常肌肉：将在体内应用MRE技术，以提供志愿者极端肌肉的弹性图像。 肌肉的基本特征，包括肌肉的模量或刚度作为张力的函数，载荷速率和扰动频率将得到验证。 还将检查肌肉内张力分布的均匀性。 目的4：利用磁共振弹性图在体内研究异常肌肉：将在体内应用MRE技术来提供异常肌肉的弹性图像，并具有已知疾病，以区分正常肌肉和患病的肌肉的生理学。该技术的成功应用将为评估各种康复程序的功效提供一种手段。