Functional Dissection of the K27M Histone Mutation in Vivo

体内 K27M 组蛋白突变的功能解析

• 批准号: 8677666
• 负责人: Oren Josh Becher
• 金额: $ 19.49万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8677666
• 关键词: Accounting; Astrocytes; Biology; Brain Neoplasms; Brain Stem; Brain Stem Glioma; Brain Stem Neoplasms; Cause of Death; Cell Proliferation; Cells; Child; Childhood Brain Neoplasm; Clinical Trials; Complex; Development; Diffuse; Disease; Dissection; Dorsal; Foundations; Gene Targeting; Genes; Genetic; Genetically Engineered Mouse; Glial Fibrillary Acidic Protein; Glioma; Gliomagenesis; Goals; Histone H3.3; Histones; Human; In Vitro; Independent Scientist Award; Laboratories; Location; Malignant Neoplasms; Malignant neoplasm of brain; Modeling; Molecular Profiling; Mus; Mutation; Neonatal; Pathogenesis; Pharmaceutical Preparations; Platelet-Derived Growth Factor; Polycomb; Pontine structure; Proto-Oncogene Proteins c-sis; Relative (related person); Reporting; Research; Scientist; Therapeutic Agents; comparative; design; effective therapy; gain of function mutation; in vivo; mouse model; mutant; nerve stem cell; nestin protein; novel; overexpression; progenitor; public health relevance; relating to nervous system; tumor; tumorigenesis

DESCRIPTION (provided by applicant): Diffuse Intrinsic Pontine Glioma (DIPG) is an incurable brain tumor that arises in children. My laboratory is one of very few laboratories around the world that is studying DIPG biology using genetically engineered mouse modeling. This Independent Scientist Award will give me the opportunity to focus on research to dissect the mechanisms by which K27M histone mutations contribute to DIPG pathogenesis. Ultimately, this information will lay the groundwork for the identification of effective therapeutic agents to treat this incurable cancer.

描述（由申请人提供）：弥漫性固有的庞然神经胶质瘤（DIPG）是儿童中发生的无法治愈的脑肿瘤。我的实验室是世界上使用基因工程的小鼠建模研究DIPG生物学的少数实验室之一。这个独立的科学家奖将使我有机会专注于研究，以剖析K27M组蛋白突变有助于DIPG发病机理的机制。最终，这些信息将为鉴定有效治疗该无法治愈的癌症的有效治疗剂奠定基础。