EEG & Behavioral Predictors of Changes in Smoking Trajectories in Young Light Smo

脑电图

• 批准号: 8852585
• 负责人: DAVID G GILBERT
• 金额: $ 43.67万
• 依托单位: SOUTHERN ILLINOIS UNIVERSITY CARBONDALE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8852585
• 关键词: Abstinence; Acute; Address; Affective; Alleles; Anterior; Attention; Behavior Therapy; Behavioral; Brain; Development; Dose; Electroencephalography; Emotional; Environment; Environmental Risk Factor; Gene Cluster; Genes; Genetic; Genetic Polymorphism; Goals; Health; Hour; Individual; Individual Differences; Intervention; Knowledge; Lead; Left; Light; Literature; Medial; Moods; Motivation; National Cancer Institute; Nicotine; Nicotine Dependence; Nicotinic Receptors; Patient Self-Report; Performance; Pharmacotherapy; Physiological; Placebo Control; Population; Prevention; Process; Prospective Studies; Psychological reinforcement; Public Health; Receptor Gene; Relapse; Relative (related person); Reporting; Research; Resistance; Rest; Rewards; Risk; Smoker; Smoking; Social Controls; Source; Stimulus; Testing; Time; Variant; Work; Youth; base; behavior measurement; behavioral response; density; distraction; endophenotype; experience; genetic variant; indexing; information processing; insight; longitudinal design; novel; public health relevance; research study; response; smoking cessation; therapy development; tomography; visual information

DESCRIPTION (provided by applicant): The proposal is to identify brain, behavioral, and self-report predictors of progression to changes in smoking rate and nicotine dependence in 128 young light smokers (YLS) in a longitudinal design using a number of novel predictors, including individual differences (IDs) in EEG and reward sensitivity at baseline and in response to standardized and to self-selected acute nicotine doses (ANIC). The associations of a compelling genetic functional variant polymorphism, rs16969968, in the alpha5 nicotinic receptor subunit will also be related to smoking progression and ANIC responses. The predictors will be attentional, affective, and reward-related processes assessed with brain (electrocortical), behavioral, and self-report indices that are well validated as responsive to ANIC in nicotine-dependent (ND) smokers. Evidence indicates that initial responses to first smoking experience, progression from light to regular smoking, and progression to ND are influenced by both genetic and environmental factors. There is good reason to hypothesize that better characterization of IDs in the effects of ANIC on attention, mood, and brain reactivity in YLS will provide important insights into mechanisms that contribute to the reinforcement of smoking and smoking trajectories in YLS. Such information could lead to targeted pharmacotherapy and behavioral interventions for at-risk YLS. The following hypotheses would be tested in a population of YLS: 1) ANIC will increase attention performance, mood, and resistance distraction by emotionally negatively valent pictures and words and that these beneficial (reinforcing) effects will predict changes in smoking rate 3, 6, 12, and 18 months later, 2) Lower baseline attentional and emotional levels will predict greater increases in smoking at the follow-ups. 3) Electrocortical (EEG, ERP, and source localization analyses) indices of low EEG activity (high theta & alpha power), reduced P3b amplitude, and greater reductions in P3b to targets following negatively valent distractor will predict increased smoking during nicotine deprived states and 4) hypotheses 1-3 will be supported even after controlling for social factors that may promote change in smoking. Secondary exploratory analyses will include the relationships of the functional variant polymorphism rs16969968 of the alpha5-alpha3-beta4 nicotinic receptor gene cluster to changes in smoking and to other predictors of change, including responses to ANIC.

描述（由申请人提供）：该建议是为了在纵向设计中识别128名年轻吸烟者（YLS）中吸烟率和尼古丁依赖性变化的大脑，行为和自我报告预测因素，并使用许多新颖的预测因子（包括EEG中的个体差异（ID），包括在基线和对基线和对分配的NIC的响应中的敏感性（IDS）（IDS）。在alpha5烟碱受体亚基中，引人入胜的遗传功能变体多态性（RS16969968）的关联也将与吸烟进展和阳离子反应有关。这些预测因素将是通过大脑（电真），行为和自我报告指数评估的注意力，情感和奖励相关的过程，这些过程在尼古丁依赖性（ND）吸烟者中得到了很好的验证。证据表明，对初次吸烟经验的最初反应，从光到常规吸烟的发展以及ND的发展受遗传和环境因素的影响。有充分的理由假设在anic对YLS注意力，情绪和大脑反应性的影响中，更好地表征ID会为有助于加强YLS吸烟和吸烟轨迹的机制提供重要的见解。此类信息可能会导致有针对性的药物治疗和高危YLS的行为干预措施。以下假设将在YLS人群中进行检验：1）Anic会通过情绪上的情感情感图片和单词来增加注意力表现，情绪和抵抗力的注意力，并且这些有益的（增强）效应将预测吸烟率3、6、6、12和18个月后的变化将在随访中的吸烟中降低基线的注意力和降低基线的注意力和较低的情绪水平。 3) Electrocortical (EEG, ERP, and source localization analyses) indices of low EEG activity (high theta & alpha power), reduced P3b amplitude, and greater reductions in P3b to targets following negatively valent distractor will predict increased smoking during nicotine deprived states and 4) hypotheses 1-3 will be supported even after controlling for social factors that may promote change in smoking.次级探索性分析将包括alpha5-Alpha3-Beta4烟碱受体基因簇的功能变异多态性rs16969968与吸烟和其他变化预测指标的关系，包括对ANIC的反应。