Relationship of Prefrontal GABA to Inhibitory Mechanisms for Response Preparation

前额叶 GABA 与反应准备抑制机制的关系

基本信息

批准号：
8730249
负责人：
RICHARD IVRY
金额：
$ 19.38万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-15 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8730249
关键词：
Accounting Adult Animals Architecture Attention Attention deficit hyperactivity disorder Behavioral inhibition Computer software Dorsal Exhibits Forms Controls Gilles de la Tourette syndrome Human Impairment Impulsivity Individual Individual Differences Laboratories Lateral Light Link Magnetic Resonance Spectroscopy Measures Methods Mission Modeling Motor Motor Cortex Motor Evoked Potentials Motor Pathways Movement Neurotransmitters Participant Physiological Play Prefrontal Cortex Preparation Process Protocols documentation Reaction Time Research Research Infrastructure Research Personnel Resolution Rest Role Saccades Sampling Shapes Signal Transduction Spinal Subgroup System Testing Transcranial magnetic stimulation Variant Work behavior measurement frontal lobe gamma-Aminobutyric Acid in vivo indexing neurochemistry neurophysiology novel novel strategies operation physical property premature prevent programs public health relevance response tool

项目摘要

DESCRIPTION (provided by applicant): This R21 proposal aims to employ a magnetic resonance spectroscopy (MRS) protocol to examine the relationship between the inhibitory neurotransmitter, gamma-aminobutyric acid (GABA), in the frontal cortex and motor system dynamics during the selection and initiation of movements as measured with transcranial magnetic stimulation (TMS) of the motor cortex. TMS studies conducted in the PI's laboratory have dissociated two inhibitory mechanisms that contribute to the selection and initiation of responses. One mechanism helps to resolve competition among co-activated responses and is associated with lateral prefrontal cortex. The other mechanism helps prevent impulsive execution of a selected response and is associated with dorsal premotor cortex. However, the relationship of these two inhibitory processes to levels of GABA within their associated frontal cortical regions has not been investigated. The proposed project will investigate this relationship through the study of individual differences at the neurochemical and neurophysiological level. The project represents a new research direction for the PI, yet is highly feasible. The PI is an expert on the motor system and the use of TMS as a tool for investigating the dynamics of response preparation. The co-investigator Dr. Richard Maddock is an expert in the use of MRS methods, specifically for measuring GABA. With Dr. Maddock's guidance, and the recent installation of MRS software at UC Berkeley, the infrastructure is in place for this work.

描述（由申请人提供）：该R21提案旨在采用磁共振光谱（MRS）方案来检查抑制性神经递质，γ-氨基丁酸（GABA），在额叶皮层和运动系统动力学过程中，以转型磁力启动（TMS）在运动过程中，在额叶皮层和运动系统中，在额叶皮层和运动系统动力学（TMMS）中（TMMS）在额叶皮层和运动系统中进行了关系。在PI实验室进行的TMS研究已经解散了两种有助于选择和启动反应的抑制作用机制。一种机制有助于解决共同激活反应之间的竞争，并与前额叶皮层有关。其他机制有助于防止冲动执行选定的响应，并与背侧前皮层相关联。但是，尚未研究这两个抑制过程与其相关额叶皮质区域内的GABA水平的关系。拟议的项目将调查这种关系通过研究神经化学和神经生理水平的个体差异。该项目代表了PI的新研究方向，但非常可行。 PI是电机系统的专家，并且使用TMS作为研究响应制备动态的工具。 Richard Maddock博士的共同投资者是使用MRS方法的专家，专门用于测量GABA。在Maddock博士的指导下，以及最近在UC Berkeley的MRS软件安装，为这项工作提供了基础设施。