Mechanisms and Biomarkers of Environmental Stress

环境压力的机制和生物标志物

基本信息

批准号：
8785870
负责人：
Yinsheng Wang
金额：
$ 0.6万
依托单位：
UNIVERSITY OF CALIFORNIA RIVERSIDE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8785870
关键词：
American Award Base Excision Repairs Biocompatible Materials Biological Markers Biology California Chemicals Chemistry DNA DNA Repair Pathway DNA lesion Development Disease Education Environmental Carcinogens Environmental Exposure Environmental Health Event Exposure to Feedback Fostering Funding Future Health Human Knowledge Learning Mission Monitor Nanotechnology National Institute of Environmental Health Sciences Oral Oxidative Stress Paper Participant Pharmaceutical Preparations Postdoctoral Fellow Process Proteins Request for Applications Research Research Personnel Role San Francisco Science Scientist Senior Scientist Societies Stress Students Toxic Environmental Substances Toxic effect Toxicology Training Travel Universities Work base environmental agent experience graduate student interdisciplinary approach lectures meetings nanotoxicology nucleobase oxidation posters professor programs public health relevance structural biology symposium

项目摘要

DESCRIPTION (provided by applicant) This application requests support for the program of the Division of Chemical Toxicology of the American Chemical Society (ACS) at its 248th National Meeting and Exposition in San Francisco, CA from August 10, 2014 to August 14, 2013. A unique feature of this ACS meeting is the broad theme of the national meeting, "Chemistry and Global Stewardship ", which aligns highlighted events across the meeting programs of all ACS divisions. The mission of the ACS Division of Chemical Toxicology is to promote the understanding of chemical mechanisms contributing to disease processes and the toxicity of environmental agents, biomaterials, drugs and endogenous chemicals. The Division integrates work in chemistry, chemical biology, structural biology, toxicology, environmental health sciences and disease mechanisms. Three interrelated symposia are planned around the central theme "Mechanisms and Biomarkers of Environmental Stress" and include invited oral presentations delivered by a diverse group of leading established and emerging scientists. The three symposia for which support is requested have particularly strong relevance to the mission of the NIEHS. The first is entitled "Biomarkers for environmental exposure" and highlights the recent advances in the discovery of biomarkers for monitoring the exposure to various environmental toxicants. The second is entitled "Biomarkers of oxidative stress" and focuses on recent developments about the use of LC-MS/MS for monitoring the oxidation products of protein and DNA. The third symposium session is entitled "Mechanisms of base excision repair" and focuses on mechanisms of DNA base excision repair, a very important DNA repair pathway for removing many single-nucleobase DNA lesions induced by environmental carcinogens. A proffered paper session and a Young Investigators Symposium offer opportunities for young scientists in training to present their primary contributions and receive critical feedback from senior experts. Other highlights are a keynote lecture by Dr. Martyn Smith (University of California Berkeley) and two high-profile award symposia (the Founders Award and the Chemical Research in Toxicology Young Investigator Award). These sessions (supported by non-federal funds) will further enhance a strong overall program and provide diverse participants an outstanding representation of current work in the chemistry and biology of environmental exposure and disease.

描述（由申请人提供）该申请要求在2014年8月10日至2013年8月14日在加利福尼亚州旧金山举行的第248届全国性会议和博览会上支持美国化学学会化学毒理学计划（ACS）。该ACS会议的一个独特功能是全国会议的广泛主题，“化学和全球管理人员”，这是一项越来越高的活动。 ACS化学毒理学司的使命是促进对有助于疾病过程的化学机制的理解以及环境剂，生物材料，药物和内源性化学物质的毒性。该部门整合了化学，化学生物学，结构生物学，毒理学，环境健康科学和疾病机制的工作。计划围绕中心主题“环境压力的机制和生物标志物”进行了三个相互关联的研讨会，其中包括由一系列领先的成立和新兴科学家进行的邀请的口头演示。请求支持的三个研讨会与NIEHS的使命特别强烈。第一个标题为“环境暴露的生物标志物”，并突出了发现生物标志物以监测暴露于各种环境有毒物质的最新进展。第二个标题为“氧化应激的生物标志物”，并着重于有关使用LC-MS/MS监测蛋白质和DNA的氧化产物的最新发展。第三次研讨会会议的标题为“基本切除修复的机制”，并着重于DNA碱基切除修复的机制，DNA碱性切除修复的机制是一种非常重要的DNA修复途径，可去除许多由环境癌引起的许多单核酶DNA病变。一项提出的论文会议和年轻的调查人员研讨会为年轻科学家提供了培训的机会，以提出其主要贡献，并从高级专家那里获得关键反馈。其他亮点是Martyn Smith博士（加利福尼亚大学伯克利分校）的主题演讲和两次备受瞩目的奖学金会所（创始人奖和毒理学化学研究年轻研究者奖）。这些会议（由非联邦基金支持）将进一步增强强大的整体计划，并为各种参与者提供了当前在环境暴露和疾病的化学和生物学中的杰出代表。