Centers for Medical Countermeasures Against Radiation

放射线医疗对策中心

• 批准号: 8940521
• 负责人: Nelson J. Chao
• 金额: $ 466.87万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-31 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8940521
• 关键词: Academic Medical Centers; Accidents; Action Potentials; Acute; Address; Animal Model; Applied Research; Area; Basic Science; Biology; Centers of Research Excellence; Childhood; Dedications; Development; Dose; Education; Elderly; Employee Strikes; Environment; Fertilization; Fostering; Funding; Goals; Health Physics; Hematopoietic; Hematopoietic System; Hour; Human; Immune; Individual; Injury; Interdisciplinary Study; Knowledge; Lead; Leadership; Lung; Medical; Medical center; Natural Immunity; Normal tissue morphology; North Carolina; Nuclear; Organ; Persons; Physics; Population; Radiation; Radiation Injuries; Radioactive; Radiobiology; Research; Research Infrastructure; Research Personnel; Research Project Grants; Scientist; Secondary to; Source; System; TimeLine; Toxic effect; Training and Education; Translational Research; Transplantation Immunology; Universities; Vertebral column; War; Work; biodefense; driving force; forest; gastrointestinal system; in vitro Assay; irradiation; member; novel; novel therapeutics; pregnant; prevent; programs; public health relevance; radiation-induced injury; research and development; response; stem cell biology; trafficking; weapons

 DESCRIPTION (provided by applicant): Concerns about global nuclear war, less likely than in the past, have been replaced by the real potential of a terrorist strike using radiological weapons. The threat of such attacks has grown in recent years, with the increased activity of global terrorist organizations and a rise in illicit trafficking of radioactive materials. Unfortuntely, very few medical products exist to counter the variety of acute and long-term toxicities that can result from nuclear or radiological attacks. There remains a great need to expand the medical options available to prevent or treat radiation-induced injury. We have formed a consortium termed Radiation Countermeasures Centers of Research Excellence (RadCCORE) to collectively and collaboratively increase possible agents to detect, mitigate and treat those people exposed to deterministic doses of radiation (www.radccore.org/). Leading scientists in the area of radiation biology, health physics, stem cell biology/transplantation and immunology have come together to form one of the most comprehensive, inclusive, inter-institutional, and interdisciplinary Center for Medical Countermeasures Against Radiation (CMCR). RadCCORE is a network of academic medical centers: Duke University, University of North Carolina, and Wake Forest University and will consist of five research projects and four support cores. A major benefit of this group of investigators has been the dedication and strength of the individuals in the areas of normal tissue injury, radiation biology, physics, training and education. Given that most of our lead compounds have progressed through the development pipeline and are now externally funded, we have selected a new set of promising countermeasures but with all the original cores and core leaders intact. This arrangement brings novel investigators, increased basic and translational science knowledge and novel mitigators to our center. This network addresses broad areas of research and has made great strides in the development of new therapeutic products to prevent short- and long-term toxicities.

 描述（由申请人提供）：对全球核战争的担忧与过去相比，已经被使用放射性武器的恐怖袭击的真正潜力所取代。近年来，随着活动的增加，此类袭击的威胁有所增加。不幸的是，目前几乎没有医疗产品能够应对核或放射性攻击可能造成的各种急性和长期毒性。我们成立了一个名为“辐射对策卓越研究中心”(RadCCORE) 的联盟，以共同协作增加可能的药物来检测、减轻和治疗那些暴露于确定性辐射剂量的人 (www.RadCCORE)。辐射生物学、健康物理学、干细胞生物学/移植和免疫学领域的顶尖科学家齐聚一堂，组建了最全面、最具包容性、跨机构和跨学科的中心之一。辐射医学对策 (CMCR) 是一个由杜克大学、北卡罗来纳大学和维克森林大学组成的学术医学中心网络，由五个研究项目和四个支持核心组成，该研究小组的一个主要好处是。鉴于我们的大多数先导化合物已通过开发渠道取得进展，并且现已获得外部资助，我们选择了一套新的化合物。有希望的对策，但与所有这种安排为我们中心带来了新的研究人员、更多的基础和转化科学知识以及新的缓解措施，该网络涉及广泛的研究领域，并在开发新的治疗产品以防止短缺方面取得了长足的进步。和长期毒性。