ALCOHOL USE DISORDER IN YOUNG WOMEN: GENETIC EPIDEMIOLOGY: MOAFTS WAVE 7

年轻女性酒精使用障碍：遗传流行病学：MOAFTS 第 7 波

基本信息

批准号：
8527625
负责人：
ANDREW C. HEATH
金额：
$ 46.43万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8527625
关键词：
21 year old Address Adolescence Adolescent Adult African American Age Alcohol abuse Alcohol consumption Alcohol dependence Alcohol or Other Drugs use Alcoholism Alcohols Anxiety Disorders Biological Birth Birth Records Child Childhood Cohort Studies Collection Conflict (Psychology)Consent Consumption DNA Data Data Analyses Data Collection Deltastab Dependence Development Diagnostic Disadvantaged Disease remission Distal Divorce Education Employment Environment Environmental Exposure Environmental Risk Factor Epidemiology Etiology European Failure Family Female Female Adolescents Forcible intercourse Funding General Population Genes Genetic Genetic Determinism Genetic Structures Genetic Variation Genotype Goals Grant Heavy Drinking Home environment Hyperactive behavior Impairment Individual Interview Joints Major Depressive Disorder Marital separation Marriage Mediating Mediator of activation protein Missouri Modeling Molecular National Institute of Child Health and Human Development Oppositional Defiant Disorder Outcome Parenting behavior Parents Participant Phenotype Preparation Preventive Intervention Prospective Studies Psychopathology Recording of previous events Recovery Reporting Reproduction Research Research Project Grants Respondent Risk Role Saliva Sample Size Sampling Sexual abuse Smoker Smoking Stepparent Substance Use Disorder Supervision Surveys Symptoms Telephone Testing Time Tobacco Dependence Tobacco use Trauma Twin Multiple Birth Twin Studies alcohol misuse alcohol related problem alcohol risk alcohol use disorder base cohort college conduct problem consumption measures depressive symptoms drinking follow-up genetic epidemiology high risk inattention informant interpersonal conflict offspring parental alcoholism peer physical abuse problem drinker prospective sample collection sex socioeconomics transmission process young adult young woman

项目摘要

We propose a wave seven telephone diagnostic interview follow-up of the MOAFTS (Missouri Adolescent Female Twin Study) young cohorts A and B (target N=2100 twin interviews), and for some participants who have not yet provided samples, saliva sample collection (target N=840) for genotyping for zygosity confirmation. MOAFTS is a prospective study of a birth cohort of female like-sex twin pairs (N=370 African- American pairs, N=1999 European/Other Ancestry pairs) identified from birth records and first assessed in adolescence, at median age 16. Goals of the project are to characterize, in a broadly representative general population female twin cohort, gene-environment interplay in alcoholism and associated substance use disorders, focusing on (i) parental alcoholism and its associated twin offspring environmental risk-exposures and outcomes, and (ii) the development and course of female drinking and alcohol-related problems, as well as other substance use and problems (particularly tobacco use and dependence), through adolescence into young adulthood, emphasizing precursors/mediators and moderators of genetic and environmental effects on both onset of and recovery from problems. In the most recent data-collection, interviews were completed with approximately 3500 respondents at ages 21-30. Wave seven will provide a further follow-up of alcohol and other substance use and problems, and proximal environmental exposures, so that most twins are through their period of greatest risk for onset of alcohol problems, and the sample will be old enough to be informative about the predictors of remission versus persistence of alcohol problems and heavy drinking (target N=700 assessed at age 30, N=1400 assessed at age 28/N=100 new dependence cases). Our research is motivated by the concern that the genetic transmission of risks of alcohol and other substance use disorders frequently occurs in the context of high-risk environmental exposures commonly associated with parental alcoholism - including interpersonal conflict and divorce or never-cohabitation, step-parent presence, childhood assaultive trauma, family socioeconomic disadvantage - risks that need not be reduced by the departure of an alcoholic parent from the home. Through completion of the wave seven data-collection and data-analyses, our goals are to understand how these early environmental exposures, in combination with genetic effects, influence onset and course of heavy drinking and alcohol problems, either directly, or through effects on timing of onset of alcohol use and on comorbid substance use, and effects on subsequent adult role changes of the twins (early or delayed parenting; relationship formation, conflict and dissolution; education completion, employment, and adult peer relationships); and to identify other variables (history of childhood or adolescent-onset psychopathology, other substance use disorders) that may mediate or moderate these relationships. Current understanding of the genetic epidemiology of female alcohol use disorders is based largely on either retrospective or underpowered studies - a gap that the MOAFTS cohort will help to fill.

我们建议对 MOAFTS（密苏里州青少年）进行第七波电话诊断访谈后续行动女性双胞胎研究）年轻队列 A 和 B（目标 N=2100 双胞胎访谈），以及一些参与者尚未提供样本、唾液样本采集（目标 N=840）用于接合性基因分型确认。 MOAFTS 是一项针对女性同性双胞胎出生队列（N = 370 名非洲裔）的前瞻性研究。美国配对，N = 1999 欧洲/其他血统配对）从出生记录中识别并首次评估青春期，中位年龄 16 岁。该项目的目标是以具有广泛代表性的一般人口女性双胞胎队列，酗酒和相关物质使用中的基因-环境相互作用疾病，重点关注 (i) 父母酗酒及其相关的双胞胎后代环境风险暴露和结果，以及 (ii) 女性饮酒和酒精相关问题的发展和进程，以及其他物质使用和问题（特别是烟草使用和依赖），从青春期到成年早期，强调遗传和环境影响的前体/中介和调节因素问题的发生和恢复。在最近的数据收集中，完成了采访大约 3500 名年龄在 21-30 岁之间的受访者。第七波将提供酒精和酒精的进一步跟踪其他物质使用和问题，以及最近的环境暴露，因此大多数双胞胎都经历了他们出现酒精问题的风险最大的时期，并且样本的年龄足以提供信息关于酒精问题和酗酒缓解与持续存在的预测因素（目标 N=700 30 岁时评估，N=1400 28 岁时评估/N=100 个新依赖病例）。我们的研究充满动力由于担心酒精和其他物质使用障碍的风险经常通过遗传传播发生在通常与父母酗酒相关的高风险环境暴露的背景下 - 包括人际冲突、离婚或从未同居、继父母的存在、童年时期的攻击行为创伤、家庭社会经济劣势——无需通过酗酒者的离开来减少的风险父母从家里来。通过完成第七波数据收集和数据分析，我们的目标目的是了解这些早期环境暴露与遗传效应相结合如何影响酗酒和酒精问题的发作和病程，无论是直接的还是通过对发作时间的影响酒精使用和共病物质使用的影响，以及对双胞胎随后成年角色变化的影响（早期或延迟养育子女；关系的形成、冲突和解除；教育完成、就业、和成人同伴关系）；并确定其他变量（童年或青少年发病史）精神病理学、其他物质使用障碍）可能会介导或缓和这些关系。当前的对女性酒精使用障碍遗传流行病学的了解主要基于回顾性或动力不足的研究——MOAFTS 队列将帮助填补这一空白。