Genetically-informed designs of externalizing behavior and romantic relationships

外化行为和浪漫关系的基因设计

基本信息

批准号：
8641885
负责人：
JESSICA E SALVATORE
金额：
$ 5.49万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-05 至 2015-09-04
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8641885
关键词：
Accounting Adult Alcohol dependence Alcohol or Other Drugs use Alcohols Antisocial Personality Disorder Behavior Behavioral Conduct Disorder Conflict (Psychology)Currently Married Data Disease Disinhibition Divorce Drug Addiction Drug abuse Drug usage Emotional Environment Environmental Risk Factor Epidemiology Fellowship Functional disorder Genes Genetic Genetic Predisposition to Disease Genetic Risk Goals Health Individual Knowledge Maintenance Marital Relationships Marital Status Marriage Measures Mediating Methods Mission Nature Never Married Outcome Phenotype Postdoctoral Individual National Research Service Award Predisposition Preventive Intervention Problem behavior Process Public Health Research Risk Behaviors Role Sampling Substance Use Disorder Training Trust Twin Multiple Birth Twin Studies Virginia Work anti social base career conflict resolution design experience externalizing behavior gene environment interaction genetics of alcoholism insight public health relevance skills trait

项目摘要

DESCRIPTION (provided by applicant): The objective of this independent postdoctoral fellowship award (F32) is to support the candidate's training goals to gain knowledge on substance use and psychiatric outcomes, expertise in genetic epidemiological and gene-finding methods, and further develop the skills needed for an academic research career. To achieve these training goals, the candidate will use genetically informed designs to characterize the associations between externalizing behavior and relationship factors. Numerous studies document associations among externalizing behavior (e.g., alcohol and illicit drug abuse and dependence and antisocial behavior), marital status, and romantic relationship dysfunction. Externalizing behavior and relationship traits are both under genetic influence; still, little is known about their associations from a genetic perspective. Characterizing these associations is important in view of growing evidence that genetic predispositions and environmental risk factors are not independent of one another. With respect to the present project, for example, behavioral disinhibition (i.e., the highly heritable factor shared among externalizing behaviors) also compromises the interpersonal processes (e.g., conflict resolution, trust, and commitment) that are central to the formation and maintenance of harmonious romantic relationships. Two central hypotheses guide this work. First, it is expected that marital status and relationship dysfunction will have a common genetic basis with externalizing behavior. Second, it is expected that, after accounting for gene-environment correlation, marital status and relationship dysfunction will moderate genetic influences on externalizing behavior. The first part of this project will use genetic epidemiological (i.e., twin) methods to examine whether externalizing behavior and romantic relationship factors share latent genetic influences and whether romantic relationship factors moderate latent genetic influences on externalizing behavior. The second part of this project will use gene-finding methods to examine whether externalizing behavior and relationship factors share measured genetic influences, and whether relationship factors moderate measured genetic influences on externalizing behavior. Thus, this work uses complementary genetically-informed methods (twin studies and gene identification methods) to determine the extent to which genetic and/or environmental influences toward externalizing behavior also influence one's propensity to marry, divorce, or have a dysfunctional relationship, and whether relationship factors moderate genetic influences on externalizing behavior. This work contributes to a central goal of psychiatric research, which is to understand how salient environmental factors, such as marital status and relationship dysfunction, come together with genetic predispositions to predict the onset and course of disorders.

描述（由申请人提供）：该独立博士后奖学金（F32）的目的是支持候选人的培训目标，以获得有关物质使用和精神病结果的知识、遗传流行病学和基因查找方法的专业知识，并进一步发展技能学术研究生涯所需的。为了实现这些培训目标，候选人将使用遗传信息设计来表征外化行为和关系因素之间的关联。许多研究记录了外化行为（例如酒精和非法药物滥用、依赖和反社会行为）、婚姻状况和恋爱关系功能障碍之间的关联。外化行为和人际关系特征都受到遗传的影响；然而，从遗传学的角度来看，人们对它们之间的联系知之甚少。鉴于越来越多的证据表明遗传倾向和环境风险因素并不是相互独立的，描述这些关联的特征非常重要。例如，就本项目而言，行为去抑制（即外化行为之间共享的高度遗传因素）也会损害人际交往过程（例如，冲突解决、信任和承诺），而这些过程对于和谐的形成和维持至关重要。浪漫的关系。两个中心假设指导着这项工作。首先，预计婚姻状况和关系功能障碍将与外化行为具有共同的遗传基础。其次，预计在考虑了基因与环境的相关性后，婚姻状况和关系功能障碍将减轻遗传对外化行为的影响。该项目的第一部分将使用遗传流行病学（即双胞胎）方法来研究外化行为和浪漫关系因素是否共享潜在的遗传影响，以及浪漫关系因素是否调节外化行为的潜在遗传影响。该项目的第二部分将使用基因查找方法来检查外化行为和关系因素是否共享测量到的遗传影响，以及关系因素是否调节测量到的遗传对外化行为的影响。因此，这项工作使用互补的遗传信息方法（双胞胎研究和基因识别方法）来确定遗传和/或环境对外化行为的影响在多大程度上也影响一个人结婚、离婚或关系失调的倾向，以及是否关系因素调节遗传对外化行为的影响。这项工作有助于实现精神病学研究的一个中心目标，即了解婚姻状况和关系功能障碍等显着环境因素如何与遗传倾向结合起来预测疾病的发作和病程。