Genome-Wide Association Studies of Adiposity in Samoans

萨摩亚人肥胖的全基因组关联研究

• 批准号: 8598505
• 负责人: Stephen T. McGarvey
• 金额: $ 55.61万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8598505
• 关键词: Abdomen; Accounting; Adult; Alcohol consumption; American; American Samoa; Architecture; Behavior; Bioinformatics; Biological; Blood Pressure; Blood specimen; Body fat; Candidate Disease Gene; China; Chinese People; Clinical Chemistry Tests; Clinical Data; Collection; Complex; Consensus; Croatia; DNA; Data; Demographic Factors; Developed Countries; Developing Countries; Diet; Disease; Economic Development; Education; Environment; Epidemiologic Studies; Exposure to; Fasting; Fatty Acids; Gene Family; Genes; Genetic; Genetic Variation; Genomics; Genotype; Glucose; Goals; Height; Heterogeneity; Hip region structure; Inherited; Insulin; Knowledge; Leptin; Life; Life Style; Lipids; Measurement; Measures; Methods; Morbidity - disease rate; Nutritional; Obesity; Occupations; Overweight; Pacific Island Americans; Pathway interactions; Pattern; Phenotype; Plasma; Population; Public Health; Recording of previous events; Recruitment Activity; Research; Risk; Rural; Samoa; Samoan; Sampling; Sampling Studies; Serum; Single Nucleotide Polymorphism; Staging; Statistical Methods; Techniques; Testing; United States; Variant; Weight; adiponectin; base; cigarette smoking; design; effective intervention; experience; follow-up; gene environment interaction; genetic analysis; genetic epidemiology; genetic linkage analysis; genetic risk factor; genetic variant; genome wide association study; high risk; mortality; novel; prevent; rural area; success; therapy development; trait

Project Summary - "Genome-wide association studies of adiposity in Samoans" The goal of this new application is to define the genetic variation that underlies obesity and obesity-related phenotypes among adult Samoans. We will use genome-wide association methods to take advantage of newer more powerful techniques to identify single nucleotide polymorphism (SNP) variants that are associated with adiposity phenotypes. We will conduct these studies using a population sample of 2,500 adults from rural areas of Samoa, an independent nation experiencing the nutritional transition. We will replicate the findings from our genome-wide association studies of important SNPs by further analysis in three different study samples: an independent sample of 2,500 Samoans from earlier studies in American Samoa and Samoa, and 1,500 adults from Croatia and 1,000 adults from China. We will then determine the sequences of the important genes and determine the specific genetic variants in the sequenced genes that are associated with obesity in these three samples. Finally, we will explore gene-environment interactions, taking advantage of identified genetic variants in the sequenced regions and the substantial environmental heterogeneity in lifestyle and nutritional behaviors within Samoa. The knowledge gained from this research will aid the development of interventions on obesity among Samoans including those in the US and may be generalizable to other Pacific Islander groups.

项目摘要 - “萨摩亚人的肥胖性基因组关联研究” 该新应用的目的是定义肥胖和与肥胖有关的遗传变异 成人萨摩亚人的表型。我们将使用全基因组的关联方法来利用更新的优势 更强大的技术来识别与之相关的单核苷酸多态性（SNP）变体 肥胖表型。我们将使用来自农村的2500名成年人的人群样本进行这些研究 萨摩亚地区是一个经历营养过渡的独立国家。我们将复制发现 从我们对重要SNP的全基因组关联研究中通过三项不同的研究进一步分析 样本：来自美国萨摩亚和萨摩亚的早期研究的2500名萨摩亚人的独立样本，以及 来自克罗地亚的1,500名成年人和中国的1,000名成年人。然后，我们将确定重要的序列 基因并确定与肥胖有关的测序基因中的特定遗传变异 这三个样本。最后，我们将利用已识别的优势探索基因环境相互作用 测序区域中的遗传变异以及生活方式的实质环境异质性 萨摩亚内的营养行为。这项研究所获得的知识将有助于发展 萨摩亚人在内的肥胖症的干预措施，包括美国的肥胖症，可能是其他太平洋 岛民团体。