Fourteenth & Fifteenth International Symposia on Neurobiology & Neuroendocrinology of Aging

第十四

基本信息

批准号：
9899821
负责人：
HOLLY M. BROWN-BORG
金额：
$ 4.05万
依托单位：
UNIVERSITY OF NORTH DAKOTA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9899821
关键词：
Address Age Aging Alzheimer&apos s Disease Area Austria Biology of Aging Caloric Restriction Cell Aging Clinical Collaborations Communication Dietary Intervention Disease Endocrine system Endocrinology Environment Epigenetic Process Faculty Funding Genomic Instability Geriatrics Gerontology Health Hormonal Human Huntington Disease Impaired cognition Inflammation International Investigation Left Link Mediator of activation protein Metabolic dysfunction Mitochondria Modeling Molecular Biology Neuraxis Neurobiology Neurodegenerative Disorders Neuroendocrinology Neurons Oral Oxidation-Reduction Parkinson Disease Participant Population Positioning Attribute Postdoctoral Fellow Publishing Regenerative research Rejuvenation Request for Applications Request for Proposals Research Research Personnel Schedule Science Scientist Senior Scientist Series Sirolimus Slide Technology Time Tissues Training Translations United States age related age related neurodegeneration aged detection of nutrient exhaustion graduate student hormone deficiency interest lectures meetings mitochondrial dysfunction neuroprotection novel posters proteostasis stem cells student conference symposium

项目摘要

Project Summary The Fourteenth and Fifteenth International Symposia on Neurobiology & Neuroendocrinology Aging will be held in Bregenz, Austria July 15-20, 2018 and in July 2020. The purpose of these meetings is to bring together a group of investigators who made recent advances in the study of mechanisms of aging, with particular emphasis on CNS aging, neuroprotection and neurodegenerative disease. Moreover, the endocrine system and metabolic dysfunction tie many additional aging research areas together (genomic instability, mitochondrial dysfunction, cellular senescence, epigenetic changes, loss of proteostasis, deregulated nutrient sensing, stem cell exhaustion, inflammation). We are directly addressing several of these topics in this Symposium, many in the context of neurobiology and endocrinology. Prominent among the scheduled lectures are the continued search for mechanisms of age-related disease, increasing appreciation of concomitant involvement of multiple interacting mechanisms, and attempts to evaluate their relative importance. Recent studies significantly increased appreciation of mediators of potential aging retardation, calorie restriction, hormone deficiency and rapamycin. Similarly, modulation of health and disease by translational dietary intervention will be addressed. As the field continues to search for and study regenerative mechanisms, talks devoted to reprogramming of aged tissue and rejuvenation are included. Several lectures will integrate information in neurobiology with aging, redox state, plasticity, and mitochondrial dynamics. Progressive changes in the age profile of human populations underlies enormous significance of age related neurodegenerative disease and cognitive impairment. The latest breakthroughs in our understanding of Alzheimer's, Parkinson's and Huntington's disease will be covered in multiple lectures, further strengthening this link. Each of these topics will be covered by investigators that recently made major advances in the corresponding areas of investigation. We purposely include a wide range of topics and assemble a group of scientists that may not normally attend the same meeting. The format of the meeting is modeled after Gordon Research Conferences and encourages formal and informal discussions of the material presented. Proceedings will be published as a special issue of Experimental Gerontology within approximately six months after the Symposium. We have always strongly encouraged the participation of junior investigators, including graduate students and postdoctoral fellows. This proposal seeks funds for providing stipends to those US participants who are in training or are in junior faculty positions and who are planning to present their findings in the poster session. We are also seeking partial support for the expenses of invited speakers from the United States.

项目摘要关于神经生物学和神经内分泌学的第十四和第14个国际座谈会衰老将于2018年7月15日至20日在奥地利的布雷氏邦举行。这些目的是会议是为了汇集一群调查人员，他们在研究中取得了最新进展衰老的机制，特别着重于中枢神经系统衰老，神经保护和神经退行性疾病。此外，内分泌系统和代谢功能障碍系列很多额外的衰老研究领域（基因组不稳定性，线粒体功能障碍，细胞衰老，表观遗传变化，蛋白质静脉曲张的丧失，养分消失，茎细胞耗尽，炎症）。我们直接解决了其中的几个主题研讨会，许多在神经生物学和内分泌学的背景下。在其中突出预定的讲座是继续寻找与年龄相关疾病的机制，增加欣赏伴随多种相互作用机制的参与，并尝试评估它们的相对重要性。最近的研究显着增加了对潜在衰老，卡路里限制，激素缺乏症和雷帕霉素的介体。同样，通过转化饮食干预对健康和疾病的调节将是解决。随着领域的继续寻找和研究再生机制，对话包括重新编程的老年组织和恢复活力。会有几次讲座将神经生物学中的信息与衰老，氧化还原状态，可塑性和线粒体相结合动力学。人口年龄概况的进行性变化是巨大的与年龄相关的神经退行性疾病和认知障碍的重要性。最新在我们对阿尔茨海默氏症，帕金森氏病和亨廷顿氏病的理解中的突破用多个讲座涵盖，进一步加强了这一联系。这些主题中的每一个都将是被调查人员覆盖，最近在相应领域取得了重大进展调查。我们故意包含各种各样的主题，并组装一群科学家通常可能不会参加同一会议。会议的格式以戈登研究会议，并鼓励对材料的正式和非正式讨论提出。会议记录将作为实验老年病的特刊发表。研讨会后大约六个月。我们一直强烈鼓励初级调查人员的参与，包括研究生和博士后研究员。这提案寻求资金为正在接受培训或正在接受培训或正在接受的美国参与者提供津贴在初级教师职位上，他们计划在海报会议上介绍他们的发现。我们还为美国受邀发言人的费用寻求部分支持。