CLINICAL CORE

临床核心

基本信息

批准号：
8450812
负责人：
LON S SCHNEIDER
金额：
$ 69万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8450812
关键词：
Abbreviations Adult Advisory Committees Aging Alzheimer&apos s Disease Antipsychotic Agents Autopsy Behavioral Biocompatible Materials Biological Brain California Cerebrovascular Disorders Chinese American Chinese People Citalopram Clinical Clinical Research Clinical Trials Data Data Set Dementia Education Effectiveness of Interventions Elderly Enrollment Evaluation Eye Finches Future Genetic Materials Glossary Guidelines Health Sciences Impaired cognition Industry Intervention Trial Knowledge Latino Longitudinal Studies Los Angeles Magnetic Resonance Imaging Mental Depression National Institute on Aging Participant Photography Pilot Projects Population Population Study Program Research Project Grants Public Health Recruitment Activity Registries Rehabilitation Centers Research Research Project Grants Research Support Resources Risk Factors Selective Estrogen Receptor Modulators Source Thick Tissues Underserved Population United States National Institutes of Health Venous brain research cardiovascular risk factor central retinal artery clinical research site cognitive change cohort cooperative study data acquisition diagnosis evaluation eligible participant follow-up genome wide association study intima media mild cognitive impairment modifiable risk neuroimaging neuropathology neuropsychological programs research study selective androgen receptor modulator

项目摘要

The Clinical Core is responsible for recruiting and maintaining a well-characterized pool of participants to support research on cognitive decline associated with aging, AD and cerebrovascular disease (CVD). Participants are evaluated at two sites: USC Health Sciences Campus and Rancho Los Amigos Natl Rehab. Center, where there are also two State-supported Alzheimer Disease Research Centers of California. The English and Spanish modules of the National Alzheimer Coordinating Center Uniform Data Set (UDS) provide the framework for standard evaluations and follow-up; a Framingham Cardiovascular Risk Profile is also obtained. Participants are evaluated from three special cohorts: the Los Angeles Latino Eye Study (LALES), the Long Beach Longitudinal Study (LBLS, Project 1: Course of Cognitive Change in Late Adulthood; PI: E. Zelinski), and the Chinese Eye Study (CHES, Project 3: the Mild Cognitive impairment in a Chinese-American Eye Study; PI: L. Zheng). The core provides the main source of brain donations (Brain Research Study) and biological material for the neuropathology core, and contributes participants to clinical trials, including the Alzheimer's Disease Cooperative Study (ADCS) and Citalopram in AD (CITAD, PI: L. Schneider). It interacts closely with the education core (EIC,M. Gatz) in recruitment and retention activities; with the data core (W. Mack) to manage data acquisition, flow, and referrals; and with the administrative core (H. Chui, C. Finch) to set strategic directions, including prioritizing research. Specific aims are to: 1. Coordinate with the EIC to recruit and retain research participants, with a special emphasis on Latino and other underserved populations. 2. Perform standardized UDS evaluations for participants with no or mild cognitive impairment and dementia, including those from LALES, LBLS Project 1, and CHES Project 3. 3. Perform UDS annual follow-ups of participants in ADRC studies, including ADNI, LBLS, CHES-MCI, and the autopsy study. 4. Coordinate with the Neuropathology Core to recruit, and follow subjects for autopsy, and obtain tissues and genetic materials for ongoing and future cooperative projects (e.g., GWAS) 5. Coordinate with the Data Core, to submit UDS data to NACC on initial and follow-up evaluations 6. Develop and maintain a registry of well-characterized participants to support ADRC-

临床核心负责招募和维持一批特征良好的参与者，以支持与衰老、AD 和脑血管疾病 (CVD) 相关的认知能力下降的研究。参与者在两个地点接受评估：南加州大学健康科学校区和兰乔洛斯阿米戈斯国家康复中心。中心，那里还有两个加州政府支持的阿尔茨海默病研究中心。国家阿尔茨海默病协调中心统一数据集（UDS）的英语和西班牙语模块提供了标准评估和随访的框架；还获得了弗雷明汉心血管风险概况。参与者从三个特殊队列中接受评估：洛杉矶拉丁裔眼科研究 (LALES)、长滩纵向研究（LBLS，项目 1：成年晚期认知变化过程；PI：E. Zelinski）和中国眼科研究（CHES，项目 3：美籍华人眼科研究中的轻度认知障碍；PI：L.郑）。该核心为神经病理学核心提供大脑捐赠（脑研究）和生物材料的主要来源，并为临床试验贡献参与者，包括阿尔茨海默病合作研究（ADCS）和西酞普兰治疗AD（CITAD，PI：L. Schneider））。它在招聘和保留活动中与教育核心（EIC、M. Gatz）密切互动；用数据核心（W. Mack）来管理数据获取、流动和转介；并与行政核心（H. Chui、C. Finch）一起制定战略方向，包括确定研究的优先顺序。具体目标是： 1. 与 EIC 协调招募和留住研究参与者，特别关注拉丁裔和其他服务不足的人群。 2. 对没有或轻度认知障碍和痴呆症的参与者进行标准化 UDS 评估，包括来自 LALES、LBLS 项目 1 和 CHES 项目 3 的参与者。 3. 对 ADRC 研究的参与者进行 UDS 年度随访，包括 ADNI、LBLS、 CHES-MCI 和尸检研究。 4. 与神经病理学核心协调，招募和跟踪受试者进行尸检，并获取组织和遗传材料以用于当前和未来合作项目（例如 GWAS） 5. 与数据核心协调，将 UDS 数据提交给 NACC 进行初步和后续评估 6. 开发和维护特征明确的参与者登记册，以支持 ADRC-