A Follow-up Study for Causes of Cancer in Black Women

黑人女性癌症病因的后续研究

• 批准号: 8735097
• 负责人: Lynn Rosenberg
• 金额: $ 126.25万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-21 至 2017-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8735097
• 关键词: 21 year old; Address; Affect; African American; Age; Air Pollution; Aliquot; Behavioral; Biological Markers; Blood; Blood specimen; Breast Cancer Risk Factor; Cancer Etiology; Cause of Death; Cells; Censuses; Cessation of life; Cheek structure; Cohort Studies; Collaborations; Collection; Colonic Adenoma; Colorectal Adenoma; Colorectal Cancer; Consent; DNA; DNA Repository; Data; Data Analyses; Data Collection; Diagnostic; Disease; Education; Enrollment; Funding; Genotype; Health; Hospitals; Incidence; Income; Knowledge; Laboratories; Link; Mails; Malignant Neoplasms; Malignant neoplasm of lung; Manuscripts; Medical; Medical Records; Methods; Morbid Obesity; Newsletter; Non-Malignant; Nonrespondent; Nurses' Health Study; Online Systems; Outcome; Participant; Pathology; Patients; Phenotype; Pilot Projects; Population; Preparation; Prevalence; Process; Protocols documentation; Publishing; Quality Control; Questionnaires; Research; Resources; Risk; Risk Factors; Sampling; Scanning; Services; Shipping; Ships; Socioeconomic Factors; Source; Specific qualifier value; Woman; Women' s Health; abstracting; biobank; burden of illness; cancer diagnosis; cancer genetics; cohort; cost; data sharing; follow-up; genetic risk factor; health disparity; malignant breast neoplasm; mortality; neoplasm registry; non-genetic; payment; psychosocial; racism; repository; reproductive; response; success

DESCRIPTION (provided by applicant): The Black Women's Health Study (BWHS), the largest follow-up study for cancer in African American (AA) women, began in 1995 when 59,000 women (median age, 38) from across the U.S. enrolled. The BWHS has successfully followed participants with biennial questionnaires for data on incident disease and medical, reproductive, behavioral, psychosocial, and socioeconomic factors, linked addresses to U.S. census data, and are currently linking to air pollution data. Cancer diagnoses are validated by pathology data from hospitals and cancer registries. A DNA bio repository was established through collection of cheek cell samples from 26,800 participants. Despite initial slow accrual of cancers due to the young age of participants at entry, the BWHS has published extensively on risk factors for breast cancer; sufficient cases of lung cancer, colorectal cancer, and colon adenomas are now available. We propose to (1) continue follow-up/data collection; (2) establish a repository of 17,800 blood samples; (3) share data/samples in consortia projects. Continuation of the BWHS is highly desirable: 90% of participants are still cancer-free; follow-up has been successful and unbiased; the cohort has reached ages at which cancer incidence increases markedly; effects of exposures (e.g., severe obesity, racism) that are less common in other populations can be studied; the DNA has made valuable contributions to genetic cancer studies and is a major replication source for studies of breast cancer and related phenotypes in AA and other groups; the BWHS is a key contributor to consortia projects of rarer cancers in /\As; and the BWHS has been highly productive. Because levels of many blood markers are unfavorable among AAs and few studies of blood biomarkers in relation to cancer incidence have been carried out specifically in /\As, we propose to establish a repository of blood samples in the BWHS. A successful pilot study demonstrated the feasibility of our methods and participation was unbiased and similar to that in other large follow-up studies. The repository will increase by 60% the limited number of AA women with available blood samples being followed in U.S. cancer cohort studies. AA women continue to be disproportionately affected by many cancers. Continuation of the BWHS will permit continuation of its valuable contributions to understanding cancer etiology in this understudied group. A blood repository will greatly increase the value of the BWHS resource by permitting studies that help to fill the knowledge gap about the relation of biomarkers to cancer incidence and survival in AAs. The assessment of serious nonmalignant illnesses in the BWHS enhances the value of this resource at no cost to the study of cancer.

描述（由申请人提供）：黑人女性健康研究 (BWHS) 是针对非裔美国 (AA) 女性癌症的最大的后续研究，于 1995 年开始，当时有来自美国各地的 59,000 名女性（中位年龄 38 岁）参加。 BWHS 已成功地对参与者进行了每两年一次的问卷调查，以获取有关事件疾病以及医疗、生殖、行为、社会心理和社会经济因素的数据，将地址与美国人口普查数据相关联，目前正在与空气污染数据相关联。癌症诊断通过医院和癌症登记处的病理数据进行验证。通过收集 26,800 名参与者的脸颊细胞样本，建立了 DNA 生物储存库。尽管由于参与者年龄较小，癌症最初的增长缓慢，但 BWHS 已发表了大量有关乳腺癌危险因素的文章；目前已有足够的肺癌、结直肠癌和结肠腺瘤病例。我们建议（1）继续跟踪/数据收集； （2）建立17,800份血液样本的储存库； (3) 在联盟项目中共享数据/样本。 BWHS 的继续是非常可取的：90% 的参与者仍然没有癌症；后续行动是成功且公正的；该群体已达到癌症发病率显着增加的年龄；可以研究在其他人群中不太常见的暴露（例如严重肥胖、种族主义）的影响； DNA对遗传性癌症研究做出了宝贵的贡献，是研究乳腺癌和AA及其他群体相关表型的主要复制来源； BWHS 是以下地区罕见癌症联盟项目的主要贡献者； BWHS 的生产力非常高。由于许多血液标志物的水平在 AA 中是不利的，并且在/\As 中专门进行了与癌症发病率相关的血液生物标志物的研究很少，因此我们建议在 BWHS 中建立血液样本存储库。一项成功的试点研究证明了我们的方法的可行性，并且参与是公正的，并且与其他大型后续研究相似。该存储库将使美国癌症队列研究中拥有可用血液样本的 AA 女性的有限数量增加 60%。 AA 女性仍然不成比例地受到多种癌症的影响。 BWHS 的继续开展将继续为了解这一未被充分研究的群体的癌症病因学做出宝贵贡献。血液储存库将通过允许研究来帮助填补有关 AA 中生物标志物与癌症发病率和生存率关系的知识空白，从而大大增加 BWHS 资源的价值。 BWHS 对严重非恶性疾病的评估增强了该资源的价值，且不影响癌症研究。