Mindfulness in Women with Polycystic Ovary Syndrome

多囊卵巢综合症女性的正念

• 批准号: 8860116
• 负责人: NAZIA T. RAJA-KHAN
• 金额: $ 13.42万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8860116
• 关键词: Acne; Address; Adherence; Adoption; Affect; Anovulation; Anxiety; Behavior; Blood Pressure; Cardiovascular Diseases; Cardiovascular system; Chronic; Clinical; Complementary therapies; Data; Development; Diabetes Mellitus; Doctor of Medicine; Dyslipidemias; Endocrine System Diseases; Endocrinologist; Epidemic; Equipment and supply inventories; Evaluation; General Population; Glucose; Glycosylated hemoglobin A; Goals; Health; Health education; Hirsutism; Homeostasis; Hormones; Hydrocortisone; Hypertension; Immune; Inflammation; Insulin Resistance; Integrative Medicine; Intervention; K-Series Research Career Programs; Measurement; Measures; Mediating; Medical; Medicine; Menstruation; Mental Depression; Mental Health; Metabolic; Metformin; Mind-Body Intervention; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Overweight; Patients; Physiological; Pilot Projects; Play; Polycystic Ovary Syndrome; Prevention; Public Health; Quality of life; Raja; Randomized; Randomized Controlled Trials; Research; Risk; Risk Factors; Role; SF-36; Salivary; Severities; Sleep disturbances; Stress; Sympathetic Nervous System; Symptoms; Woman; aged; base; body dissatisfaction; cardiometabolic risk; cardiovascular disorder risk; career; design; diabetes risk; diet and exercise; endothelial dysfunction; evidence base; experience; hypothalamic-pituitary-adrenal axis; impaired glucose tolerance; improved; indexing; interest; mindfulness; mindfulness meditation; mindfulness-based stress reduction; mortality; novel; patient population; pressure; prevent; primary outcome; programs; psychologic; psychological distress; psychological outcomes; reproductive; skills; treatment strategy

Nazia Raja-Khan, M.D. is an endocrinologist with a long-term career goal of establishing an integrative medicine research program for Polycystic Ovary Syndrome (PCOS) aimed at integrating evidence-based non-conventional complementary therapies with conventional medical therapies for PCOS to optimize psychological and cardiometabolic health in PCOS. PCOS is a common endocrine disorder that affects 5-10% of reproductive-aged women. Women with PCOS are at increased risk for psychological distress, which may contribute to their increased risk for diabetes and cardiovascular disease. However, there is a lack of effective strategies for managing psychological distress in PCOS. Mindfulness-Based Stress Reduction (MBSR) reduces psychological distress in various patient populations and a pilot study showed that MBSR lowers glucose and blood pressure. Therefore, MBSR could significantly impact PCOS by reducing psychological distress and cardiometabolic risk; however, MBSR has not been investigated in PCOS. MBSR may have similar benefits for overweight or obese women who do not have PCOS (non-PCOS) as stress is also believed to play a major role in obesity. Our objective is to conduct a pilot randomized controlled trial investigating the feasibility and effects of MBSR in PCOS and non-PCOS women who are overweight or obese. Ninety eight (98) women will be randomized to 8-weeks of MBSR or health education control and followed for 16 weeks. The overall hypothesis is that MBSR will reduce cardiometabolic risk and psychological distress and improve quality of life in PCOS and non-PCOS women. Specific Aims are to: 1) Determine the effects of MBSR compared to health education control on changes in mindfulness, primarily assessed with the Toronto Mindfulness Scale; 2) Conduct a preliminary evaluation of the effects of MBSR compared to health education control on hemoglobin A1c, mean arterial pressure (MAP), quality of life, and overall psychological distress; 3) Explore physiologic mechanisms potentially mediating the effects of MBSR, including salivary cortisol and insulin resistance measured by homeostasis model assessment (HOMA-IR). This career development award will provide Dr. Raja-Khan with the skills, experience, and preliminary data to develop a competitive R01 proposal to more comprehensively investigate the effects and mechanisms of MBSR in PCOS. This research will inform the development of novel integrative mind-body approaches for PCOS, diabetes, and cardiovascular disease.

Nazia Raja-Khan 医学博士是一位内分泌学家，其长期职业目标是建立多囊卵巢综合症 (PCOS) 的综合医学研究计划，旨在将基于证据的非常规补充疗法与 PCOS 的传统医学疗法相结合，以优化心理和 PCOS 患者的心脏代谢健康。 PCOS 是一种常见的内分泌疾病，影响 5-10% 的育龄女性。患有多囊卵巢综合症的女性遭受心理困扰的风险增加，这可能导致她们患糖尿病和心血管疾病的风险增加。然而，缺乏有效的策略来管理多囊卵巢综合症患者的心理困扰。基于正念的减压 (MBSR) 可减少各种患者群体的心理困扰，一项试点研究表明 MBSR 可以降低血糖和血压。因此，MBSR 可以通过减少心理困扰和心脏代谢风险来显着影响 PCOS；然而，MBSR 尚未在 PCOS 中进行研究。 MBSR 对于没有 PCOS（非 PCOS）的超重或肥胖女性可能也有类似的好处，因为压力也被认为是导致肥胖的重要因素。我们的目标是进行一项随机对照试验，调查 MBSR 对超重或肥胖的 PCOS 和非 PCOS 女性的可行性和效果。九十八 (98) 名女性将被随机分配接受为期 8 周的 MBSR 或健康教育对照，并进行为期 16 周的随访。 总体假设是，MBSR 将降低 PCOS 和非 PCOS 女性的心脏代谢风险和心理困扰，并提高生活质量。具体目标是： 1) 确定与健康教育控制相比，MBSR 对正念变化的影响，主要使用多伦多正念量表进行评估； 2）初步评估MBSR与健康教育控制相比对血红蛋白A1c、平均动脉压（MAP）、生活质量和整体心理困扰的影响； 3）探索潜在介导MBSR影响的生理机制，包括通过稳态模型评估（HOMA-IR）测量的唾液皮质醇和胰岛素抵抗。该职业发展奖将为 Raja-Khan 博士提供技能、经验和初步数据，以制定具有竞争力的 R01 提案，以更全面地研究 MBSR 在 PCOS 中的作用和机制。这项研究将为治疗多囊卵巢综合症、糖尿病和心血管疾病的新型身心综合方法的开发提供信息。