Mindfulness in Women with Polycystic Ovary Syndrome

多囊卵巢综合症女性的正念

基本信息

批准号：
8189739
负责人：
NAZIA T. RAJA-KHAN
金额：
$ 13.2万
依托单位：
PENNSYLVANIA STATE UNIV HERSHEY MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8189739
关键词：
Acne Address Adherence Adoption Affect American Anovulation Anxiety Applications Grants Behavior Biometry Blood Glucose Blood Pressure C-reactive protein Cardiology Cardiovascular Diseases Chronic Clinical Clinical Trials Complementary therapies Data Development Diabetes Mellitus Doctor of Medicine Dyslipidemias Educational process of instructing Effectiveness Endocrine System Diseases Endocrinologist Epidemic Equipment and supply inventories Evaluation Foundations Functional disorder Future General Population Glucose Glycosylated hemoglobin A Goals Grant Healed Health Health education Hirsutism Homeostasis Hypertension Immune Inflammation Informal Social Control Institute of Medicine (U.S.)Insulin Resistance Integrative Medicine Intervention Studies K-Series Research Career Programs Life Measures Mediating Medical Medicine Menstruation Mental Depression Mental Health Mentors Metabolic syndrome Metformin Mind-Body Intervention Mission Modeling National Center for Complementary and Alternative Medicine Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Patients Perception Physiological Pilot Projects Polycystic Ovary Syndrome Prevention Psychology Public Health Quality of life Questionnaires Raja Randomized Randomized Controlled Trials Recovery Research Research Personnel Research Project Grants Resources Risk Risk Factors Role Science Severities Sleep disturbances Sympathetic Nervous System Symptoms Training Activity Woman Work aged base body dissatisfaction brachial artery cardiovascular disorder risk career comparative effectiveness coping design diabetes risk diet and exercise effectiveness research empowered evidence base experience healing health related quality of life hypothalamic-pituitary-adrenal axis impaired glucose tolerance improved indexing innovation mindfulness mindfulness meditation mindfulness-based stress reduction mortality novel patient population pressure prevent primary outcome programs psychologic psychological distress psychological outcomes reproductive response secondary outcome skills treatment strategy

项目摘要

Nazia Raja-Khan, M.D. is an endocrinologist with a long-term career goal of establishing an integrative medicine research program for Polycystic Ovary Syndrome (PCOS) aimed at integrating evidence-based non-conventional complementary therapies with conventional medical therapies for PCOS to optimize psychological and cardiometabolic health in PCOS. PCOS is a common endocrine disorder that affects 5-10% of reproductive-aged women. Women with PCOS are at increased risk for psychological distress, which may contribute to their increased risk for diabetes and cardiovascular disease. However, there is a lack of effective strategies for managing psychological distress in PCOS. Mindfulness-Based Stress Reduction (MBSR) reduces psychological distress in various patient populations and a pilot study showed that MBSR lowers glucose and blood pressure. Therefore, MBSR could significantly impact PCOS by reducing psychological distress and cardiometabolic risk; however, MBSR has not been investigated in PCOS. MBSR may have similar benefits for overweight or obese women who do not have PCOS (non-PCOS) as stress is also believed to play a major role in obesity. Our objective is to conduct a pilot randomized controlled trial investigating the feasibility and effects of MBSR in PCOS and non-PCOS women who are overweight or obese. Ninety eight (98) women will be randomized to 8-weeks of MBSR or health education control and followed for 16 weeks. The overall hypothesis is that MBSR will reduce cardiometabolic risk and psychological distress and improve quality of life in PCOS and non-PCOS women. Specific Aims are to: 1) Determine the effects of MBSR compared to health education control on changes in mindfulness, primarily assessed with the Toronto Mindfulness Scale; 2) Conduct a preliminary evaluation of the effects of MBSR compared to health education control on hemoglobin A1c, mean arterial pressure (MAP), quality of life, and overall psychological distress; 3) Explore physiologic mechanisms potentially mediating the effects of MBSR, including salivary cortisol and insulin resistance measured by homeostasis model assessment (HOMA-IR). This career development award will provide Dr. Raja-Khan with the skills, experience, and preliminary data to develop a competitive R01 proposal to more comprehensively investigate the effects and mechanisms of MBSR in PCOS. This research will inform the development of novel integrative mind-body approaches for PCOS, diabetes, and cardiovascular disease.

医学博士Nazia Raja-Khan是一名内分泌学家，其长期职业目标是为多囊卵巢综合征（PCOS）建立综合医学研究计划（PCOS），旨在与PCOS的常规医疗疗法相结合，以将基于证据的非惯性互补疗法整合到PCOS中的心理和心脏代谢健康。 PCOS是一种常见的内分泌疾病，影响5-10％的生殖妇女。患有PCOS的妇女患心理困扰的风险增加，这可能导致她们患糖尿病和心血管疾病的风险增加。但是，缺乏在PCOS中管理心理困扰的有效策略。基于正念的压力减轻（MBSR）减少了各种患者人群的心理困扰，而一项试点研究表明，MBSR降低了葡萄糖和血压。因此，MBSR可以通过减少心理困扰和心脏代谢风险来显着影响PCOS；但是，MBSR尚未在PCOS中进行研究。 MBSR可能对没有PCOS（非PCO）的超重或肥胖女性具有类似的好处，因为压力也被认为在肥胖症中起主要作用。我们的目标是进行一项试验随机对照试验，研究MBSR对超重或肥胖的PCOS和非PCOS妇女的可行性和影响。九十八（98）名妇女将被随机分为8周的MBSR或健康教育控制，然后进行16周。总体假设是MBSR将减少心脏代谢风险和心理困扰，并改善PCOS和非PCOS妇女的生活质量。具体目的是：1）确定MBSR与健康教育控制对正念变化相比的影响，主要通过多伦多的正念量表进行评估； 2）与健康教育控制对血红蛋白A1C，平均动脉压（MAP），生活质量和整体心理困扰相比，对MBSR的影响进行初步评估； 3）探索生理机制可能介导MBSR的作用，包括通过稳态模型评估（HOMA-IR）测量的唾液皮质醇和胰岛素抵抗。该职业发展奖将为Raja-Khan博士提供技能，经验和初步数据，以开发竞争性的R01建议，以更全面地研究MBSR对PCOS的效果和机制。这项研究将为PCOS，糖尿病和心血管疾病的新型综合思维方法的发展提供信息。