Training Program in Brain Tumor Biology

脑肿瘤生物学培训计划

• 批准号: 8871806
• 负责人: Etty N Benveniste
• 金额: $ 19万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8871806
• 关键词: Brain Neoplasms; Training Programs; Tumor Biology

DESCRIPTION (provided by applicant): The multidisciplinary UAB Training Program in Brain Tumor Biology trains highly motivated predoctoral students and Ph.D. and M.D. graduates in the fields of fundamental and translational brain tumor biology. The program builds on the interdisciplinary basic and translational investigative efforts supported by the Neuro- Oncology Program and the UAB Brain Tumor SPORE Grant. Seventeen faculty members serve as mentors on this training program. Key partners are the thematically based Graduate Biomedical Sciences Program, the UAB MSTP Program and the Office of Postdoctoral Education. The Brain Tumor Training Program incorporates faculty committed to training in the fields of oncolytic properties of mutant herpes viruses, novel clinical applications of monoclonal antibody therapy, signal transduction pathways, systems biology, bioinformatics, genomics, kinomics, innate immune response, glioma stem cells, invasive and angiogenic mechanisms, bio-energetics and oxidative stress. An effective interdisciplinary training program requires faculty with collaborative and synergistic scientific interests. A Pub-Med search of the 17 mentors revealed that 95% published with at least one other mentor. This committed training environment provides an ideal setting for the implementation of interdisciplinary research and training. Over the last five years, 8 postdoctoral and 6 predoctoral trainees have been supported, with 13 of 14 continuing in biomedical research, teaching and/or training. The success of this program is evident by the outstanding publication record of the trainees, having published 48 peer-reviewed manuscripts in highly competitive journals, with an additional 11 under review or in preparation. A major effort has been made to recruit under-represented minorities and to enhance gender equality among the trainees. Our trainees have been 57% male (8/14) and 43% female (6/14), and have included 22% under-represented minorities (3/14; African American and Hispanic American). They have trained with 10 primary or co-mentors from 7 departments. Because a large number of our mentors are involved in patient care in addition to their research activities, the program provides a strong interface between basic and applied brain tumor biology. The Training Program provides an exceptional interdisciplinary environment in terms of didactic training and enrichment opportunities. The didactic component encompasses the Advanced Course in Brain Tumor Biology, a new course entitled Brain Tumor Clinical Course, and a new "hand-on" TCGA/Bioinformatics Tutorial. Enrichment activities include a new Monthly Research-In-Progress Brain Tumor Conference, a Monthly Brain Tumor Research Seminar Series, and the Annual UAB Brain Tumor SPORE Scientific Retreat. Collectively, the research training, didactic training and enrichment activities will ensure the development of the next generation of basic/translational researchers addressing the compelling problems related to brain tumors.

描述（由申请人提供）：脑肿瘤生物学中的多学科UAB培训计划训练高度积极的专业学生和博士学位。和医学博士在基本和翻译脑肿瘤生物学领域的毕业生。该计划基于神经肿瘤学计划和UAB脑肿瘤孢子赠款支持的跨学科基础和翻译调查工作。 17名教职员工担任该培训计划的导师。主要合作伙伴是基于主题的研究生生物医学科学计划，UAB MSTP计划和博士后教育办公室。脑肿瘤训练计划结合了致力于在突变疱疹病毒的溶晶特性领域进行培训的教师，单克隆抗体治疗的新临床应用，信号转导途径，系统生物学，生物信息学，生物信息学，基因组学，基因组学，动力学学，固有的免疫反应，胶质瘤细胞，胶质性疾病，舌剂，敏感性和敏感性。有效的跨学科培训计划需要具有协作和协同科学利益的教师。对17位导师的酒吧搜索搜索表明，有95％的人与至少一位导师一起出版。这个致力于的培训环境为实施跨学科研究和培训提供了理想的环境。在过去的五年中，支持了8个博士后和6名托管学员，在生物医学研究，教学和/或培训中，有14名继续进行。该计划的成功是从学员的出色出版记录中明显的，在高度竞争期刊上发表了48次同行评审的手稿，并在审查中又进行了11份或准备。已经做出了巨大的努力，以招募代表性不足的少数群体并提高学员之间的性别平等。我们的学员的男性为57％（8/14）和43％的女性（6/14），其中包括22％代表不足的少数民族（3/14；非裔美国人和西班牙裔美国人）。他们已经培训了来自7个部门的10名主要或联合官员。由于我们的许多导师除了研究活动外还参与了患者护理，因此该计划在基本和应用的脑肿瘤生物学之间提供了强烈的界面。该培训计划在教学培训和丰富机会方面提供了卓越的跨学科环境。教学成分涵盖了脑肿瘤生物学的高级课程，标题为“脑肿瘤临床课程”的新课程以及新的“手工” TCGA/生物信息学教程。富集活动包括新的每月进行研究的脑肿瘤会议，每月的脑肿瘤研究研讨会系列和一年一度的UAB脑肿瘤孢子科学静修。总的来说，研究培训，教学培训和丰富活动将确保发展下一代基本/翻译研究人员，这些研究人员解决了与脑肿瘤有关的引人入胜的问题。