Biomedical Informatics

生物医学信息学

• 批准号: 8934309
• 负责人: STEPHEN G EMERSON
• 金额: $ 9.01万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8934309
• 关键词: Adoption; Applications Grants; Area; Basic Science; Bioinformatics; Biology; Biomedical Computing; Cancer Center Support Grant; Cancer Research Project; Clinical Informatics; Clinical Investigator; Clinical Pathology; Clinical Research; Clinical Trials; Collaborations; Communities; Computer software; Core Facility; Data; Data Analyses; Data Set; Databases; Electronics; Faculty; Funding; Genomics; High Performance Computing; Human Resources; Individual; Institution; Leadership; Maintenance; Methodology; Mission; Modeling; Molecular; Nafion; Positioning Attribute; Publications; Research; Research Infrastructure; Research Methodology; Research Personnel; Resource Sharing; Resources; Role; Services; System; Translational Research; Universities; Work; analytical method; anticancer research; biological research; biomedical informatics; cancer Biomedical Informatics Grid; catalyst; computer cluster; computer infrastructure; computerized tools; computing resources; cost effective; data acquisition; data management; data sharing; experience; forging; genome-wide; informatics shared resource; novel; programs; success; tool

The mission of the Biomedical Informatics Shared Resource (BISR) is to support HICCC investigators in four critical areas including: • Adoption, support, and maintenance of an electronic, caBIG compliant, centralized clinical trial management system; • Access to key expertise in the use of advanced data analysis tools and methodologies for research publications and grant proposals, reflecting established best practices; • Access to state-of-the-art software, databases, and models for basic and clinical research; • Access to high-performance computing infrastructure for data analysis and data sharing. The BISR director and deputy director (Drs. Califano and Hripcsak) have extensive experience respectively in bioinformatics and clinical informatics, are active in the conduct of basic and clinical research, and have made key contributions to Columbia's current position as a leading institution in biomedical informatics. While increasingly vital to the success of cancer research projects, biomedical informatics support is often not available to experimental and clinical investigators. The BISR allows HICCC investigators to tap into a vast array of biomedical informatics resources at CU by providing advanced data analysis services, biomedical informatics tools and databases, and one of the largest academic computer clusters dedicated to biological research. BISR leadership also acts as a catalyst in forging new collaborations between HICCC investigators and more than 40 biomedical informatics faculty at CU. Specifically, the BISR supports the CRMO data acquisition and management requirements, works with a large team of caBIG/NCI funded programmers developing integrative bioinformatics platforms (geWorkbench), supports all caBIG initiatives at CU, and is piloting the integration of pathology, clinical, and genomic data for translational research. Currently, a large and increasing contingent of HICCC investigators have successfully used the shared resource and the BISR has been instrumental in the submission of a vast majority of funded proposals since the last review cycle, including several R01s, large Program Projects, and a U54 for the creation of a National Center for Biomedical Computing.

生物医学信息学共享资源（BISR）的使命是支持HICCC调查人员 四个关键领域，包括： •采用，支持和维护电子，符合CABIG的集中式临床试验 管理系统； •访问使用高级数据分析工具和研究方法的关键专业知识 出版物和赠款提案，反映了既定的最佳实践； •访问基本和临床研究的最先进的软件，数据库和模型； •访问用于数据分析和数据共享的高性能计算基础架构。 BISR董事兼副董事（Califano博士和HRIPCSAK博士）分别具有丰富的经验 在生物信息学和临床信息中 对哥伦比亚目前作为生物医学信息的领先机构的职位做出了重要贡献。 尽管对癌症研究项目的成功越来越重要，但生物医学信息的支持通常是 实验和临床研究人员无法使用。 BISR允许HICCC调查人员利用 通过提供高级数据分析服务，CU的大量生物医学信息资源， 生物医学信息工具和数据库，也是最大的学术计算机簇之一。 生物学研究。 BISR领导力还可以作为催化剂在建立新的合作 HICCC的研究人员和CU的40多个生物医学信息教师。具体而言，BISR 支持CRMO数据获取和管理要求，与大型团队合作 Cabig/NCI资助的程序员开发综合生物信息学平台（Geworkbench），支持 CU的所有Cabig倡议，正在试行病理，临床和基因组数据的整合 翻译研究。目前，HICCC调查人员的大量且越来越多 成功使用共享资源，而BISR在提交疫苗方面发挥了作用 自上次审查周期以来，大多数资助的提案，包括几个R01，大型计划项目， 以及创建国家生物医学计算中心的U54。