Health Disparities in Chronic Kidney Disease Mentoring Program

慢性肾脏病指导计划中的健康差异

• 批准号: 8911296
• 负责人: JAMES P. LASH
• 金额: $ 17.94万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-20 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8911296
• 关键词: ARHGEF5 gene; Achievement; Adherence; Adult; Affect; Age; Area; Award; Cardiovascular system; Caregivers; Chicago; Child; Childhood; Chronic; Chronic Kidney Failure; Chronic Kidney Insufficiency; Clinical; Clinical Research; Cohort Studies; Complex; Diet; Disease; Epidemiology; Ethnic Origin; Event; Funding; Goals; Guidelines; Health; Health Services Accessibility; Health behavior; Hispanics; Household; Illinois; Individual; Kidney Diseases; Low income; Mediator of activation protein; Medicine; Mentors; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Minority; Minority Groups; National Institute of Diabetes and Digestive and Kidney Diseases; Neighborhoods; Nephrology; Outcome; Physical activity; Physicians; Policies; Population; Principal Investigator; Public Health Schools; Race; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Training; Resources; Scientist; Smoking; Socioeconomic Status; Solid; Therapeutic; Time; Training; Training Programs; Translational Research; United States; United States National Institutes of Health; Universities; Work; adverse outcome; cardiovascular risk factor; career; cohort; experience; health disparity; health literacy; innovation; mortality; patient oriented; patient oriented research; professor; programs; skills; success; therapy development

DESCRIPTION (provided by applicant): Chronic kidney disease (CKD) afflicts more than 26 million individuals in the United States and it is well established that racial/ethnic minorities ae disproportionately affected by this chronic condition. The factors responsible for this disparity are complex and incompletely understood. Despite the critical need for more research in this area, decreasing number of trainees are choosing careers in academic nephrology. The K24 Midcareer Investigator Award in Patient- Oriented Research provides a unique mechanism to assist established investigators to attract and retain talented new physician-scientists to careers in patient-oriented research. The candidate for this K24 is James Lash, MD, an Associate Professor of Medicine at the University of Illinois at Chicago (UIC). Dr. Lash's research focuses on the epidemiology of CKD with a particular emphasis on minority populations. He has considerable experience as a patient- oriented researcher and is the Principal Investigator for two NIDDK-sponsored studies: 1) the Chronic Renal Insufficiency Cohort (CRIC) Study and 2) the Hispanic CRIC Study. These studies, as well as several other multicenter collaborative studies, provide a wealth of opportunities for trainees. Dr. Lash has developed a solid track record for mentoring young investigators, including a significant number from minority backgrounds. The new research program funded by this award is a natural extension of Dr. Lash's ongoing work and will provide additional opportunities for trainees. It consists of two projects which focus on potential factors contributing to disparities in adults and children with CKD: 1) individual/neighborhood socioeconomic status, and 2) health literacy. This proposed research leverages the infrastructure of two large ongoing cohort studies (the CRIC Study and Chronic Kidney Disease in Children Study) and therefore, provides a unique opportunity to examine these factors in both children and adults with CKD. In addition to mentored research, trainees will participate in didactic training through the UIC K30 Clinical Research Training Program and have access to the extensive resources and infrastructure provided by the UIC Center for Clinical Translational Science (CCTS), the UIC School of Public Health, and the UIC P60 Center for Excellence in Health Disparities. This K24 award will provide Dr. Lash with the additional time and resources to amplify his efforts in contributing to our understanding of health disparities in CKD and in training new physician scientists to become independent investigators in kidney disease research.

描述（由申请人提供）：美国有超过 2600 万人患有慢性肾病 (CKD)，并且众所周知，少数种族/族裔尤其受这种慢性病的影响。造成这种差异的因素很复杂且不完全清楚。尽管该领域迫切需要更多的研究，但选择学术肾脏病学职业的学员数量却在减少。 K24 以患者为导向的研究中的职业中期研究者奖提供了一种独特的机制，帮助现有的研究者吸引和留住有才华的新医生科学家。 在以患者为导向的研究中。 K24 的候选人是医学博士 James Lash，他是伊利诺伊大学芝加哥分校 (UIC) 的医学副教授。 Lash 博士的研究重点是 CKD 的流行病学，特别是少数群体。作为以患者为中心的研究人员，他拥有丰富的经验，并且是 NIDDK 资助的两项研究的首席研究员：1) 慢性肾功能不全队列 (CRIC) 研究和 2) 西班牙裔 CRIC 研究。这些研究以及其他几项多中心合作研究为学员提供了丰富的机会。拉什博士在指导年轻研究人员方面有着良好的记录，其中包括大量来自少数族裔背景的研究人员。该奖项资助的新研究项目是拉什博士正在进行的工作的自然延伸，并将为学员提供更多机会。它由两个项目组成，重点关注导致 CKD 成人和儿童差异的潜在因素：1) 个人/社区社会经济地位，2) 健康素养。这项拟议的研究利用了两项正在进行的大型队列研究（CRIC 研究和儿童慢性肾病研究）的基础设施，因此提供了一个独特的机会来检查患有 CKD 的儿童和成人中的这些因素。除了指导研究之外，学员还将通过 UIC K30 临床研究培训计划参加教学培训，并可以使用 UIC 临床转化科学中心 (CCTS)、UIC 公共卫生学院和UIC P60 健康差异卓越中心。 K24 奖项将为 Lash 博士提供额外的时间和资源，以加强他为我们对健康的理解做出贡献的努力 CKD 方面的差异以及培训新的医师科学家成为肾脏疾病研究的独立研究者方面的差异。