Delaware Valley Node of the Clinical Trials Network

临床试验网络特拉华谷节点

基本信息

批准号：
7386428
负责人：
GEORGE Edward WOODY
金额：
$ 33万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-09-30 至 2010-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7386428
关键词：
10p AIDS prevention AIDS/HIV problem ARHGEF5 gene Accounting Accreditation Achievement Acquired Immunodeficiency Syndrome Addendum Address Adherence Administrator Admission activity Adolescent Adopted Adoption Adult Advisory Committees Advocate Affect African African American Age Age-Years Agonist Agreement Alcohol dependence Alcohol or Other Drugs use Alcoholism All Sites Altitude Amendment American Ancillary Study Antidepressive Agents Antiviral Agents Appendix Applications Grants Appointment Area Arts Asians Attention Attitude Award Back Baltimore Baseline Surveys Behavior Behavior Therapy Behavioral Belief Biological Biological Psychiatry Board Certification Boxing Brazil Budgets Buprenorphine Businesses CPDD protocol Calculi Caring Censuses Characteristics Charge Child Chronic Disease Cities Classification Clergy Client Clinic Clinical Clinical Data Clinical Investigator Clinical Research Clinical Trials Clinical Trials Network Clinical Trials, Other Clonidine Cocaine Cocaine Dependence Code Cognitive Cognitive Therapy Collaborations Communicable Diseases Communication Communities Community Health Education Community Participation Computer software Condition Conduct Clinical Trials Conflict (Psychology)Consensus Consent Consult Consultations Contractor Contracts Controlled Clinical Trials Copyright Cost Effectiveness Analysis Cost Savings Costs and Benefits Counseling Count Country County Criminal Justice Custom DSM-IV DSM-V Data Data Analyses Data Collection Databases Day Care Delaware Depressed mood Depth Detox Development Diabetes Mellitus Diagnosis Diagnostic Dictionary Diffusion of Innovation Disease Distress Doctor of Medicine Doctor of Philosophy Documentation Dose Dropout Drops Drug Addiction Drug Courts Drug Metabolic Detoxication Drug abuse Drug usage Dryopteris filix-mas Education Educational process of instructing Effectiveness Effectiveness of Interventions Electronic Mail Electronics Elements Eligibility Determination Employee Enrollment Ensure Equilibrium Equipment Equipment and Supplies Ethnic Origin Evaluation Event Evidence based intervention Evidence based practice Exclusion Criteria Experimental Designs Exploratory/Developmental Grant for Diagnostic Cancer Imaging Faculty Family psychotherapy Fee-for-Service Plans Feedback Fees Female Financial Support Florida Food Fostering Foundations Frequencies Friends Funding Funding Agency Future Gender General Hospitals Generations Generic Drugs Genes Genetic Goals Grant Guidelines HIV HIV Infections HIV prevention trials network HIV vaccine Halfway Houses Hallucinogens Head Health Health Personnel Health Services Health Services Research Health system Healthcare Hearing Hepatitis C Heroin Heroin Dependence Heterosexuals Hispanics Homelessness Homosexuals Horns Hospitalization Hospitals Hour Household Housing Human Resources Hybrids Hylobates Genus Hypertension Ice Incentives Incidence Individual Industry Infection Informatics Information Systems Injection of therapeutic agent Inpatients Institute of Medicine (U.S.)Institutes Insurance Interest Group International Internet Intervention Interview Interviewer Intravenous Investigation Joint Commission on Accreditation of Healthcare Organizations Journals Knowledge Lead Leadership Learning Left Letters Libraries Licensing Life Style Literature Location Long Island Maine Maintenance Manuals Manuscripts Marijuana Marketing Maryland Measurement Measures Mediation Medical Medical Students Medical center Medicine Mental Depression Mental Health Mental disorders Mentors Methadone Methadyl Acetate Methods Mind Minority Mission Modality Modeling Modification Monitor Mothers Multi-Institutional Clinical Trial Naloxone Naltrexone Names National Institute of Drug Abuse National Institute on Alcohol Abuse and Alcoholism Neurology New England New Jersey New Mexico Newsletter Nicotine None or Not Applicable Numbers Nurses Nuts Occupations Online Systems Operations Research Operative Surgical Procedures Opiate Addiction Opiates Opioid Oregon Organizational Policy Other Finding Outcome Outpatients Pain Paper Parents Participant Patient Self-Report Patients Pediatric Hospitals Peer Review Pennsylvania Performance Personal Communication Personal Satisfaction Persons Pharmaceutical Preparations Pharmacological Treatment Pharmacology Pharmacotherapy Phase Philadelphia Physician Executives Physicians Pilot Projects Plague Play Policies Population Positioning Attribute Pre-study Pregnant Women Preparation Presbyterian Church Prevention Prevention education Prevention intervention Primary Health Care Principal Investigator Procedures Process Professional counselor Progress Reports Propoxyphene Protocol Compliance Protocols documentation Provider Psyche structure Psychiatric Diagnosis Psychiatrist Psychiatry Psychotherapy Public Health Public Opinion Publications Published Comment Publishing Purpose Qualifying Race Randomized Randomized Controlled Clinical Trials Range Rate Readiness Reading Recording of previous events Records Recovery Recruitment Activity Registered nurse Regulation Regulatory Affairs Rehabilitation therapy Relapse Reporting Research Research Activity Research Design Research Infrastructure Research Institute Research Personnel Research Project Grants Research Training Resolution Resources Rest Review, Systematic (PT)Riots Risk Risk Assessment Risk Behaviors Risk Factors Risk Reduction Role Running Rural Russia Safety Sampling Schedule Schools Science Screening procedure Senior Scientist Award Series Services Severities Shelter facility Site Sleep Disorders Slide Solid Solutions Sorbus Source Specific qualifier value Spirituality Staging Standards of Weights and Measures Stigmata Stream Structure Students Study Section Subgroup Substance Use Disorder Substance abuse problem Suggestion Supervision Surveys Symptoms System TNFRSF11B gene Technology Technology Transfer Telephone Testing Text Therapeutic Therapeutic Intervention Therapeutic community technique Thinking Time Title Today Trainers Training Training Training and Education Trauma Travel Treatment Cost Treatment Efficacy Treatment Protocols Treatment outcome USA Georgia United States Department of Veterans Affairs United States Food and Drug Administration United States National Academy of Sciences United States National Institutes of Health United States Substance Abuse and Mental Health Services Administration Universities Unsafe Sex Update Vaccines Vagina Veterans Visit Voice Voting Vulnerable Populations Washington Week Western Asia Georgia Wine Woman Women&apos s Group Wood material Work Writing Youth addiction adolescent smoking alcohol and other drug alcohol effect antiretroviral therapy authority base bean behavioral health capitate bone career clinical research site clinically relevant college comparative compliance behavior concept contingency management cooking cooperative study cost cost effective cost effectiveness data integrity data management day design disorder risk drug of abuse drug standard editorial expectation experience falls fighting follow-up human subject improved indexing infancy inner city innovation insight instrument interest lectures lens locust male malignant breast neoplasm medical schools member men men who have sex with men men&apos s group methadone clinic/center model design motivational enhancement therapy neglect neuroimaging neurosurgery news organizational structure outreach program payment prescription document prescription procedure professor programs protocol development psychosocial quality assurance research and development research study response safer sex satisfaction simulation size skills smoking cessation social social stigma success symposium tau Proteins tool treatment center treatment program treatment site volunteer willingness young adult

项目摘要

The PI, Co-Pi, Key Personnel and other staff of the Delaware Valley Node (DVN) have substantial breadth and depth of experience in treating persons with substance use disorders and carrying out clinical trials involving pharmacologic, behavioral, and health services research, as well as studies focusing on HIV, genetics, and neuroimaging. This application responds to the specific requirements of the RFA by presenting the DVN capabilities in three parts: Part A is a Description of the DVN including how it contributes to the overall goals of the CTN; information about faculty, staff, and community treatment providers (CTPs); an organizational chart illustrating its management structure; and a narrative describing how our organizational components work to implement multi-site trials and disseminate evidence-based practices. The DVN draws upon the considerable strengths of the University of Pennsylvania, the Treatment Research Institute, and leading CTPs from Pennsylvania, New Jersey and Delaware. Importantly, all DV Node CTPs have experience and enthusiasm as practice/research partners. To strengthen our ability to implement studies related to HIV and other infectious diseases, two infectious disease clinics (IDCs) have been added to the DVN. Part B is a Progress Report with a summary of accomplishments over the past five years including: enrollment data for all CTN protocols, ancillary studies, and platform studies in which the DVN participated. The ten research concepts proposed by the DV Node are presented, followed by a summary of two protocols the DVN was approved to lead. The procedures employed in these protocols, specific lessons learned, and contributions that resulted are briefly described. Our contributions to the CTN infrastructure and its ongoing management are summarized, along with a description of the DVN's training, education, dissemination, and technology transfer activities. Part C is a Research Concept entitled "Integrating Substance Abuse Treatment into Infectious Disease Clinics." It proposes to test two models for treating individualswho have HIV or HepC and receive antiviral treatment in Infectious Disease Clinics (IDCs): integrated substance abuse treatment onsite at the IDC; or referral to a nearby! substance abuse program, which is treatment as usual. Primary outcomes are reduction in substance use, reduction in HIV risk behavior, and compliance with antiviral treatment. If accepted by the CTN with positive results, the findings could reduce substance use and improve the outcome of treatment for persons with substance use disorders who have HIV and HepC, and reduce behaviors that spread HIV and other infectious diseases.

特拉华谷节点 (DVN) 的 PI、Co-Pi、关键人员和其他工作人员具有广泛的广度和能力在治疗物质使用障碍患者和开展涉及以下方面的临床试验方面拥有丰富的经验药理学、行为和健康服务研究，以及针对艾滋病毒、遗传学和神经影像学。该应用程序通过提供 DVN 功能来响应 RFA 的特定要求三个部分：A 部分是 DVN 的描述，包括它如何为 CTN 的总体目标做出贡献；有关教职员工和社区治疗提供者 (CTP) 的信息；说明其组织结构图管理架构；以及描述我们的组织组件如何实施多站点的叙述试验并传播基于证据的做法。 DVN 充分利用了英国大学的强大优势宾夕法尼亚州、治疗研究所以及来自宾夕法尼亚州、新泽西州和特拉华州的主要 CTP。重要的是，所有 DV 节点 CTP 都拥有作为实践/研究合作伙伴的经验和热情。加强我们的由于有能力开展与艾滋病毒和其他传染病相关的研究，两个传染病诊所 (IDC) 拥有已添加至 DVN。 B 部分是进度报告，总结了过去五年的成就包括：所有 CTN 协议、辅助研究和 DVN 参与的平台研究的入组数据。介绍了 DV 节点提出的十个研究概念，随后总结了 DVN 的两个协议被批准领导。这些协议中采用的程序、吸取的具体经验教训以及贡献简要描述了结果。我们对 CTN 基础设施及其持续管理的贡献是总结，并描述 DVN 的培训、教育、传播和技术转让活动。 C 部分是一个研究概念，题为“将药物滥用治疗纳入传染病” 诊所。”它建议测试两种治疗 HIV 或 HepC 患者并接受抗病毒治疗的模型在传染病诊所 (IDC)：IDC 现场综合药物滥用治疗；或转介至附近！药物滥用计划，即照常治疗。主要成果是减少物质使用、减少 HIV 危险行为以及抗病毒治疗的依从性。如果 CTN 接受并取得积极结果，则调查结果可以减少物质使用并改善患有物质使用障碍的人的治疗结果 HIV 和 HepC，并减少传播 HIV 和其他传染病的行为。