The Role of Diet-induced Obesity in Cognitive Impairment

饮食引起的肥胖在认知障碍中的作用

• 批准号: 8925161
• 负责人: Catrina Sims Robinson
• 金额: $ 20.6万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8925161
• 关键词: Academia; Academic achievement; Achievement; Adult; Affect; African American; Age; Alabama; Alzheimer' s Disease; American; Aptitude; Award; Basic Science; Behavior; Blood - brain barrier anatomy; Book Chapters; Brain; Cerebrospinal Fluid; Clinical Sciences; Cognition; Cognition Disorders; Cognitive; Cognitive deficits; Collaborations; Communities; Data; Dementia; Development; Development Plans; Diet; Dietary Intervention; Disease Progression; Doctor of Philosophy; Educational workshop; Electrophysiology (science); Ensure; Environment; Epidemic; Euglycemic Clamping; Faculty; Fatty acid glycerol esters; Female; Fostering; Foundations; Funding; Genes; Gerontology; Glucose; Glucose Clamp; Goals; Grant; Health; Hippocampus (Brain); Hyperinsulinism; Impaired cognition; Impairment; Incidence; Individual; Insulin; Insulin Resistance; K-Series Research Career Programs; Knowledge; Laboratories; Lead; Learning; Link; Long-Term Potentiation; Maintenance; Manuscripts; Measures; Mediating; Medical Technology; Memory; Mentors; Metabolic; Metabolic Diseases; Metabolic syndrome; Michigan; Modeling; Monitor; Mus; Nerve Degeneration; Nervous System Physiology; Neuraxis; Neurology; Neuromuscular Diseases; Neuronal Plasticity; Neurosciences; Obesity; Onset of illness; Peripheral; Pharmacologic Substance; Pharmacology and Toxicology; Play; Population; Positioning Attribute; Prevalence; Productivity; Public Health; Publishing; Reporting; Research; Research Personnel; Risk; Rodent Model; Role; Science; Secure; Signal Transduction; Staging; Stroke; Structure; Synapses; Synaptic plasticity; Syndrome; Technology; Testing; Training; United States; Universities; Volunteerism; Weight; Work; aging population; base; behavior test; career; career development; cognitive change; cognitive function; design; economic cost; experience; graduate student; improved; in vivo; innovation; insulin sensitizing drugs; insulin signaling; medical schools; medical specialties; member; multidisciplinary; neuro-oncology; obesity in children; prevent; programs; receptor; response; skills; success; symposium; synaptic function; therapy development

DESCRIPTION (provided by applicant): Dr. Catrina Robinson's aptitude and commitment to succeed has been consistently exemplified through academia, interdisciplinary achievements, and volunteerism. She graduated cum laude with a B.S. degree in Laboratory Technology/Medical Technology from Auburn University, Auburn, Alabama, in 2004, with numerous academic achievements. Dr. Robinson continued to exemplify academic excellence during her graduate career at Auburn University where she received three different "Outstanding Graduate Student of the Year" awards. She was the first African American female to earn a Ph.D. in Pharmaceutical Sciences with a specialty in Pharmacology and Toxicology from Auburn University in 2007. Upon joining Dr. Eva Feldman's laboratory as a Research Fellow in January 2008, Dr. Robinson quickly became an important and productive member of the scientific team. She was awarded a 1-year position on the highly competitive Neurology T32 Training Grant and then a 2-year position of the Bio gerontology T32 Training Grant. Overall, throughout her graduate and academic career, Dr. Robinson has published 11 manuscripts including one book chapter, with one additional first-author manuscript currently under review. Dr. Robinson was promoted to Research Investigator in the Neurology Department at the University of Michigan in November of 2011. Her continued success and progress attest to her determination to be a successful independent investigator. Environment The University of Michigan provides an excellent environment for Dr. Robinson to achieve and excel as an independent investigator. The Department of Neurology in the Medical School at the University of Michigan offers a vast spectrum of clinical and basic science specialties, including stroke, neuromuscular disease, neurooncology, and a cognitive disease program. The multidisciplinary environment within the neuroscience community at the University of Michigan will foster cooperation, collaboration, productivity and an overall focused research plan. Furthermore, the strong collaboration between Dr. Robinson, Dr. Feldman, Dr. Murphy, and her Career Committee forms the core of Dr. Robinson's scientific training and will provide her with the necessary career guidance to ensure success. Research Plan Obesity increases the risk for cognitive impairment. Given that both obesity and cognitive impairment are epidemics in the United States, it is imperative to understand the mechanisms linking the two together. Studies have demonstrated that improving insulin signaling in the central nervous system (CNS) has a positive impact on cognition; however, obese individuals are excluded from such studies. This is likely due to lack of knowledge of the correlation between obesity and insulin signaling in the CNS. The first aim of assesses the impact of obesity on insulin signaling in the hippocampus. We hypothesize that CNS insulin resistance is a major contributing factor to reduced levels of insulin in the CNS. Furthermore, while it has been established that insulin plays a role in hippocampal synaptic plasticity and cognition, it is not known whether obesity- induced effects in the CNS are reversible. As the population of obese children and adults continue to age, it is important to develop effective strategies to prevent a public health crisis among this population. Therefore, the second aim of the current proposal evaluates the potential long-term impact of obesity on neuroplasticity. We contend that synaptic and cognitive changes will have long-lasting consequence that cannot be overcome with dietary intervention. Together, the findings in the proposed studies will have a tremendous impact on the field by bridging the gap between obesity and cognitive impairment. Career Goals and Career Development Plan this proposal is essential to promote Dr. Robinson's career development and to lay the research foundation for her laboratory. Her goal is to become a highly trained independent investigator with a focus on linking metabolic syndrome and Alzheimer's disease onset and progression. This K01 career development award will provide the foundation for her to develop the skills to become an expert and productive member of the neuroscience community. Specifically, the career development plan outlined for Dr. Robinson consists of an integrated program of career development workshops, multidisciplinary conferences, and practical research experiences that will establish a strong foundation in neurodegeneration, obesity, publishing and securing funding, and project management. This program will be overseen by an enthusiastic and supportive mentoring team from multiple departments at the University of Michigan. The expertise that Dr. Robinson will gain from the group of mentors and consultants will prove to be vital to her development into a young independent neuroscientist.

描述（由申请人提供）：Catrina Robinson博士的能力和成功的承诺一直通过学术界，跨学科成就和志愿服务得到体现。她以学士学位毕业。 2004年，阿拉巴马州奥本的奥本大学实验室技术/医疗技术学士学位，并取得了许多学业成绩。罗宾逊博士在奥本大学的研究生生涯中继续体现了学术卓越，在那里她获得了三项不同的“年度最佳研究生”奖。她是第一位获得博士学位的非裔美国女性。 2007年，奥本大学（Auburn University）的药理学和毒理学专业专业的药学科学专业。2008年1月加入伊娃·费尔德曼（Eva Feldman）博士的实验室研究员，罗宾逊博士很快成为了科学团队的重要成员。她在竞争激烈的神经病学T32培训补助金上获得了1年的职位，然后获得了生物老年学T32培训补助金的2年职位。总体而言，在整个研究生和学术生涯中，鲁滨逊博士都出版了11本手稿，其中包括一本书章节，目前正在审查另外一份第一名手稿。罗宾逊博士于2011年11月被晋升为密歇根大学神经病学系的研究研究员。她的成功和进步证明了她成为成功的独立研究者的决心。环境密歇根大学为鲁滨逊博士提供了一个绝佳的环境，以实现并脱颖而出。密歇根大学医学院神经学系提供了各种临床和基础科学专业，包括中风，神经肌肉疾病，神经学和认知疾病计划。密歇根大学神经科学社区内的多学科环境将促进合作，合作，生产力和整体重点研究计划。此外，罗宾逊博士，费尔德曼博士，墨菲博士和她的职业委员会之间的强有力合作构成了鲁滨逊博士的科学培训的核心，并将为她提供确保成功的必要职业指导。研究计划肥胖增加了认知障碍的风险。鉴于肥胖和认知障碍都是美国的流行病，因此必须了解将两者联系在一起的机制。研究表明，改善中枢神经系统（CNS）中的胰岛素信号传导对认知有积极影响。但是，肥胖个体被排除在此类研究之外。这可能是由于缺乏对中枢神经系统中肥胖和胰岛素信号传导之间相关性的知识。评估肥胖对海马中胰岛素信号传导的影响的第一个目的。我们假设CNS胰岛素抵抗是CNS中胰岛素水平降低的主要因素。此外，虽然已经确定胰岛素在海马突触可塑性和认知中起作用，但尚不清楚肥胖诱导的中枢神经系统中的作用是否可逆。随着肥胖儿童和成人的人口的持续衰老，制定有效的策略以防止这种人口中的公共卫生危机非常重要。因此，当前建议的第二个目的评估了肥胖对神经塑性的潜在长期影响。我们认为，突触和认知变化将带来长期的后果，而饮食干预将无法克服。共同，拟议的研究中的发现将通过弥合肥胖和认知障碍之间的差距来对现场产生巨大影响。职业目标和职业发展计划这一建议对于促进鲁滨逊博士的职业发展和为实验室奠定研究基金会至关重要。她的目标是成为一名训练有素的独立研究者，重点是将代谢综合征和阿尔茨海默氏病的发作和进展联系起来。这个K01职业发展奖将为她奠定基础，以发展成为神经科学社区的专家和生产力的技能。具体来说，鲁滨逊博士概述的职业发展计划包括一个综合的职业发展研讨会，多学科会议和实践研究经验，这些计划将在神经变性，肥胖，出版和获得资金和项目管理方面建立牢固的基础。该计划将由密歇根大学多个系的热情和支持的指导团队监督。罗宾逊博士将从导师和顾问中获得的专业知识将被证明对她成为年轻独立的神经科学家的发展至关重要。