Electromechanical Modeling Approach in Assessing Female SUI

评估女性 SUI 的机电建模方法

• 批准号: 8845194
• 负责人: Yingchun Zhang
• 金额: $ 21.83万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8845194
• 关键词: Aging; Applications Grants; Biomechanics; Biomedical Engineering; Biomedical Research; Clinical; Clinical Research; Elderly; Electrical Engineering; Engineering; Female; Five-Year Plans; Fostering; Functional disorder; Future; Goals; Interdisciplinary Study; Lead; Mechanics; Menopause; Modality; Modeling; Muscle Fatigue; Patients; Pelvis; Prevalence; Research; Research Proposals; Scientist; Stress Urinary Incontinence; Techniques; Testing; Therapeutic; Training; Urethra; Urinary Incontinence; Woman; age effect; base; biomechanical model; career; expectation; experience; innovation; interest; minimally invasive; multidisciplinary; novel

As a resubmission, the proposed five-year plan will train me and foster my launch into an independent interdisciplinary research career. My multidisciplinary background in Biomedical Engineering, Electrical Engineering and Mechanical Engineering fields and my outstanding experience in advanced biomechanical modeling and electrophysiological modeling research have fostered my interest and given me unique advantages in conducting interdisciplinary biomedical research in Urinary Incontinence (UI). The immediate goal is to prepare for a career as an independent scientist and to develop a novel subject-specific electromechanical pelvic model based urethrovaginal support and urethral function assessment (UUFA) technique to minimally invasively and quantitatively assess these two etiologic factors and to investigate the specific changes associated with aging effects that cause the increase in prevalence of SUI in women. The central hypothesis behind this research is that urethrovaginal support and urethral function in women and aging effects on female SUI can be minimally invasively and quantitatively assessed and characterized using a subject-specific pelvic modeling approach. Primary Hypothesis #1 is that urethral function in women can be minimally invasively and quantitatively assessed using a subject-specific electrophysiological pelvic modeling approach. Primary Hypothesis #2 is that urethrovaginal support function in women can be non-invasively and quantitatively assessed using a subject-specific biomechanical pelvic modeling approach. Primary Hypothesis #3 is that aging will cause poor urethrovaginal support and/or urethral dysfunction which will lead to SUI. Primary Hypothesis #4 is that a female continence profile can be created to predict the status of continence in women in women clinically and to suggest optimal therapeutic modalities for specific patients. We propose four Specific Aims (SA) to test these Hypotheses: SA #1: To develop a subject- specific electrophysiological pelvic model based periurethral muscle fatigue assessment (UMFA) technique to minimally invasively and quantitatively assess urethral function in women. Primary Hypothesis #1 will be tested. SA #2: To develop a subject-specific biomechanical pelvic model based urethrovaginal support function assessment (USFA) technique to non-invasively and quantitatively assess urethrovaginal support function in women. Primary Hypothesis #2 will be tested. SA #3: To investigate aging effects on urethral function and urethrovaginal support in young/elderly female subjects with/without SUI using the UUFA technique which consists of the UMFA and USFA techniques. Primary Hypothesis #3 will be tested. SA #4: To develop a female SUI profile as a clinical standard of female SUI by utilizing the UUFA technique to quantitatively characterize SUI etiologic factors in urethrovaginal support and urethral function in women. Primary Hypothesis #4 will be tested. At the completion of this project, it is our expectation that we will have established and validated the UUFA technique and the feasibility of its application in clinical studies, and have achieved a better understanding of the contributions of specific changes associated with aging and menopause to these etiologic factors in women.

作为重新提交，拟议的五年计划将训练我并促进我的发射到独立的 跨学科研究职业。我的生物医学工程中的多学科背景，电气 工程和机械工程领域以及我在高级生物力学方面的杰出经验 建模和电生理建模研究引起了我的兴趣，并赋予了我独特的 进行尿失禁（UI）进行跨学科生物医学研究的优势。直接 目标是为作为独立科学家的职业做准备，并开发特定于新颖的主题 基于机电骨盆模型的尿道阴道支持和尿道功能评估（UUFA） 微创和定量评估这两个病因学因素的技术，并研究 与衰老效应相关的特定变化，导致女性SUI患病率的增加。这 这项研究背后的中心假设是女性的尿道血管支持和尿道功能 并且对女性SUI的衰老影响可以微创和定量评估，并且 使用特定于主体的骨盆建模方法进行表征。主要假设1是尿道 可以使用特定于受试者特异 电生理骨盆建模方法。主要假设＃2是尿道血管支撑功能 妇女可以使用主体特异性的生物力学骨盆进行无创和定量评估 建模方法。主要假设＃3是衰老会导致尿道阴道支持不良和/或尿道 功能障碍将导致SUI。主要假设＃4是可以创建女性的界限概况 在临床上预测女性女性的持续性状态，并提出最佳的治疗方式 具体患者。我们提出了四个特定目标（SA）来检验这些假设：SA＃1：开发一个主题 - 基于特定的电生理骨盆模型基于尿道周围的肌肉疲劳评估（UMFA）技术 微创和定量评估女性的尿道功能。主要假设＃1将进行测试。 SA＃2：开发基于特定主题的基于特定主题的生物力学模型尿道阴道支持功能 评估（USFA）技术可无创和定量评估尿道阴道支持功能 女性。主要假设2将进行测试。 SA＃3：研究对尿道功能的衰老影响和 使用UUFA技术的年轻/老年女性受试者的年轻/老年女性受试者的尿道阴道支持 由UMFA和USFA技术组成。主要假设＃3将进行测试。 SA＃4：开发一个 通过利用UUFA技术来定量，女性SUI概况作为女性SUI的临床标准 表征女性尿道阴道支持和尿道功能的SUI病因学因素。主要假设 ＃4将进行测试。该项目完成后，我们期望我们已经建立并 验证了UUFA技术及其在临床研究中的可行性，并实现了 更好地理解与衰老和更年期相关的特定变化的贡献 女性的病因学因素。

项目成果

Pelvic floor dynamics during high-impact athletic activities: A computational modeling study.

• DOI: 10.1016/j.clinbiomech.2016.11.003
• 发表时间: 2017-01
• 期刊: Clinical biomechanics (Bristol, Avon)
• 作者: Dias N;Peng Y;Khavari R;Nakib NA;Sweet RM;Timm GW;Erdman AG;Boone TB;Zhang Y
• 通讯作者: Zhang Y

Functional mapping of the pelvic floor and sphincter muscles from high-density surface EMG recordings.

• DOI: 10.1007/s00192-016-3026-4
• 发表时间: 2016-11
• 期刊: International urogynecology journal
• 影响因子: 1.8
• 作者: Peng Y;He J;Khavari R;Boone TB;Zhang Y
• 通讯作者: Zhang Y