Electromechanical Modeling Approach in Assessing Female SUI

评估女性 SUI 的机电建模方法

• 批准号: 7989378
• 负责人: Yingchun Zhang
• 金额: $ 8.98万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7989378
• 关键词: Age; Aging; Applications Grants; Biomechanics; Biomedical Engineering; Biomedical Research; Clinical; Clinical Research; Elderly; Electrical Engineering; Engineering; Female; Five-Year Plans; Fostering; Functional disorder; Future; Goals; Interdisciplinary Study; Lead; Mechanics; Menopause; Modality; Modeling; Muscle Fatigue; Patients; Pelvis; Prevalence; Research; Research Proposals; Scientist; Stress Urinary Incontinence; Techniques; Testing; Therapeutic; Training; Urethra; Urinary Incontinence; Woman; age effect; base; career; expectation; experience; innovation; interest; minimally invasive; multidisciplinary; novel; public health relevance

DESCRIPTION (provided by applicant): As a resubmission, the proposed five-year plan will train me and foster my launch into an independent interdisciplinary research career. My multidisciplinary background in Biomedical Engineering, Electrical Engineering and Mechanical Engineering fields and my outstanding experience in advanced biomechanical modeling and electrophysiological modeling research have fostered my interest and given me unique advantages in conducting interdisciplinary biomedical research in Urinary Incontinence (UI). The immediate goal is to prepare for a career as an independent scientist and to develop a novel subject-specific electromechanical pelvic model based urethrovaginal support and urethral function assessment (UUFA) technique to minimally invasively and quantitatively assess these two etiologic factors and to investigate the specific changes associated with aging effects that cause the increase in prevalence of SUI in women. The central hypothesis behind this research is that urethrovaginal support and urethral function in women and aging effects on female SUI can be minimally invasively and quantitatively assessed and characterized using a subject-specific pelvic modeling approach. Primary Hypothesis #1 is that urethral function in women can be minimally invasively and quantitatively assessed using a subject-specific electrophysiological pelvic modeling approach. Primary Hypothesis #2 is that urethrovaginal support function in women can be non-invasively and quantitatively assessed using a subject-specific biomechanical pelvic modeling approach. Primary Hypothesis #3 is that aging will cause poor urethrovaginal support and/or urethral dysfunction which will lead to SUI. Primary Hypothesis #4 is that a female continence profile can be created to predict the status of continence in women in women clinically and to suggest optimal therapeutic modalities for specific patients. We propose four Specific Aims (SA) to test these Hypotheses: SA #1: To develop a subject- specific electrophysiological pelvic model based periurethral muscle fatigue assessment (UMFA) technique to minimally invasively and quantitatively assess urethral function in women. Primary Hypothesis #1 will be tested. SA #2: To develop a subject-specific biomechanical pelvic model based urethrovaginal support function assessment (USFA) technique to non-invasively and quantitatively assess urethrovaginal support function in women. Primary Hypothesis #2 will be tested. SA #3: To investigate aging effects on urethral function and urethrovaginal support in young/elderly female subjects with/without SUI using the UUFA technique which consists of the UMFA and USFA techniques. Primary Hypothesis #3 will be tested. SA #4: To develop a female SUI profile as a clinical standard of female SUI by utilizing the UUFA technique to quantitatively characterize SUI etiologic factors in urethrovaginal support and urethral function in women. Primary Hypothesis #4 will be tested. At the completion of this project, it is our expectation that we will have established and validated the UUFA technique and the feasibility of its application in clinical studies, and have achieved a better understanding of the contributions of specific changes associated with aging and menopause to these etiologic factors in women. PUBLIC HEALTH RELEVANCE: In this research proposal an urethrovaginal support and urethral function assessment (UUFA) technique will be developed based on an advanced electromechanical pelvis modeling approach. The primary impact of this research would lead to a minimally invasive technique to quantitatively assess urethrovaginal support and urethra function in women which are common etiologic factors associated with stress urinary incontinence (SUI). The UUFA technique will further help us characterize the specific changes associated with aging that cause the increase in prevalence of SUI in women.

描述（由申请人提供）：作为重新提出，拟议的五年计划将训练我并促进我的发射到独立的跨学科研究职业。我在生物医学工程，电气工程和机械工程领域的多学科背景以及在先进的生物力学建模和电生理建模研究方面的杰出经验增强了我的兴趣，并赋予了我在进行跨学科生物医学研究方面的独特优势（UI）。直接的目标是为作为独立科学家的职业做准备，并开发出一种新型主题特定的机电骨盆模型基于基于基于尿道的尿道阴道支持和尿道功能评估（UUFA）技术，以微创和定量评估这两个病因学因素，并调查导致Suii in of Sui In of Sui的衰老效应的特定变化。这项研究背后的中心假设是，尿道阴道支持和尿道功能在女性中，对女性SUI的衰老作用可以微创，并使用主题特定的骨盆建模方法进行定量评估和表征。主要假设1是，可以使用主题特异性的电生理骨盆建模方法对女性的尿道功能进行微创和定量评估。主要假设2是，使用受试者特异性的生物力学骨盆建模方法，可以非侵入性地评估女性的尿道血管支持功能。主要假设3是衰老会导致尿道血管支撑和/或尿道功能障碍，这将导致SUI。主要假设＃4是可以创建女性脱节型，以预测女性在临床上女性的持续性状态，并为特定患者提出最佳的治疗方式。我们提出了四个特定目标（SA）来检验这些假设：SA＃1：基于基于特定的特定于特定的电生理骨盆模型基于尿道周围的肌肉周围肌肉疲劳评估（UMFA）技术，以微创和定量评估女性的尿道功能。主要假设＃1将进行测试。 SA＃2：开发基于特定主题的生物力学模型模型，基于尿道阴道支持功能评估（USFA）技术，以非侵入性和定量评估女性的尿道血管支撑功能。主要假设2将进行测试。 SA＃3：使用由UMFA和USFA技术组成的UUFA技术，研究对具有/没有SUI的年轻/老年女性受试者对尿道功能和尿道血管支撑的衰老影响。主要假设＃3将进行测试。 SA＃4：通过利用UUFA技术来定量地表征女性尿道血管支持和尿道功能的SUI病因因素，以将女性SUI概况作为女性SUI的临床标准。主要假设＃4将进行测试。该项目完成后，我们期望我们将建立和验证UUFA技术及其在临床研究中的可行性，并更好地理解与女性对这些病因学因素有关的特定变化的贡献。 公共卫生相关性：在这项研究建议中，将根据先进的机电骨盆建模方法开发尿道阴道支持和尿道功能评估（UUFA）技术。这项研究的主要影响将导致一种微创技术，以定量评估女性的尿道血管支撑和尿道功能，这是与压力尿失禁相关的常见病因（SUI）。 UUFA技术将进一步帮助我们表征与衰老相关的特定变化，从而导致女性SUI患病率的增加。