Smart Wireless Microinfusion System

智能无线微输液系统

基本信息

批准号：
8927022
负责人：
Christian A. Gutierrez
金额：
$ 35万
依托单位：
FLUID SYNCHRONY, LLC
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-15 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8927022
关键词：
Academia Acute Address Aggressive behavior Animal Experimentation Animal Model Animal Welfare Animals Automation Award Behavior Behavioral Research Biomedical Research California Catheters Chronic Clinical Research Computer software Data Development Devices Dose Drug Controls Drug Delivery Systems Drug Industry Electronics Ensure Event External Infusion Pumps Health Hormones Housing Image Implant Implantable Infusion Pumps Implantable Pump Infection Infusion Pumps Infusion procedures Injection of therapeutic agent Institutes Laboratory Animals Liquid substance Luciferases Manuals Miniaturization Movement Mus Needles Neurosciences Neurosciences Research Operative Surgical Procedures Outcome Peptides Performance Personal Computers Pharmaceutical Preparations Pharmacology and Toxicology Phase Physiology Process Property Pump Readiness Regimen Research Research Personnel Risk Rodent Small Business Innovation Research Grant Small Interfering RNA Stress System Technology Testing Time Tissues Titrations Transgenic Mice United States National Institutes of Health Universities Update Vision Wireless Technology base behavioral study bioluminescence imaging biomaterial compatibility clinical care design drug development drug discovery graphical user interface implantation improved in vivo innovation intraperitoneal liquid formulation luciferin miniaturize novel strategies operation pre-clinical research programs prototype response restraint small molecule tool

项目摘要

DESCRIPTION (provided by applicant): Our vision is to realize a smart vivarium whereby a network of implanted microinfusion pumps may be remotely controlled from a single computing station. Automation of drug administration and on demand dose adjustment in freely-moving animals offers greater throughput and improved outcomes compared to existing technologies. Towards this end, this proposal focuses on the development of a wirelessly-operated micro infusion pump system scaled for small laboratory animals that provides controlled drug administration of any liquid formulation regardless of physicochemical properties. This wireless and implantable system also offers improvements in animal welfare by eliminating catheter tethers and the use of restraints. Such a drug delivery platform can benefit investigators from many NIH institutes supporting the biomedical, neuroscience, and behavioral research. Micropumps and wireless controllers were successfully demonstrated in NIH-sponsored research at the University of Southern California, but the research devices were assembled manually one at a time and customized to a specific application. Fluid Synchrony LLC, a university-based startup, was formed to transition these tools from lab-to-marketplace and address demand for these micropump systems by animal researchers from academia, pharmaceuticals industry, and clinical research organizations. Fluid Synchrony received an NSF Phase 1 SBIR award to establish feasibility of (1) pump component miniaturization, (2) wireless control and operation of a single pump, and (3) benchtop verification of a prototype pump system. This NIH SBIR proposal will advance commercial readiness by demonstrating robust control of multiple pumps simultaneously, in vivo verification in multiple mice under vivarium conditions with bioluminescence imaging, and micropump implantation biocompatibility. Three specific aims are proposed: Specific Aim 1: Develop robust inductive power transfer system for orientation-independent wireless activation of multiple pumps per cage. Specific Aim 2: Demonstration of consistent wirelessly performance of single and multiple pumps. Specific Aim 3: In vivo demonstration of group wireless dosing and bioluminescence imaging.

描述（由申请人提供）：我们的愿景是实现智能饲养箱，通过该智能饲养箱可以从单个计算站远程控制植入的微输注泵网络。与现有技术相比，自由活动动物的药物管理自动化和按需剂量调整可提供更大的通量和更好的结果。为此，该提案的重点是开发一种适用于小型实验动物的无线操作微型输液泵系统，该系统可以为任何液体制剂提供受控的药物管理，无论理化性质如何。这种无线植入式系统还通过消除导管系绳和约束装置的使用来改善动物福利。这样的药物输送平台可以使许多支持生物医学、神经科学和行为研究的 NIH 机构的研究人员受益。微型泵和无线控制器在美国国立卫生研究院资助的南加州大学研究中得到了成功演示，但这些研究设备是一次手动组装一个，并根据特定应用进行定制。 Fluid Synchrony LLC 是一家基于大学的初创公司，其成立的目的是将这些工具从实验室转移到市场，并满足学术界、制药行业和临床研究组织的动物研究人员对这些微型泵系统的需求。 Fluid Synchrony 获得了 NSF 第一阶段 SBIR 奖，以确立 (1) 泵组件小型化、(2) 单个泵的无线控制和操作以及 (3) 原型泵系统的台式验证的可行性。 NIH SBIR 提案将通过展示同时对多个泵的稳健控制、使用生物发光成像在饲养条件下对多只小鼠进行体内验证以及微泵植入生物相容性来推进商业准备。提出了三个具体目标：具体目标 1：开发强大的感应电力传输系统，用于每个笼子中多个泵的方向无关的无线激活。具体目标 2：演示单个泵和多个泵的一致无线性能。具体目标 3：群体无线给药和生物发光成像的体内演示。