Multi-scale Orbitofrontal Networks Underlying Reward Processing

奖励处理背后的多尺度眶额网络

基本信息

  • 批准号:
    8868828
  • 负责人:
  • 金额:
    $ 13.05万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-04-15 至 2020-03-31
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): In substance abuse disorders, cravings and relapses can occur even after long periods of abstinence, posing a key challenge for successful long-term treatment. These phenomena arise when brain circuits that support reward-based learning and decision-making associate arbitrary cues with behaviorally reinforcing effects of drugs. The orbitofrontal cortex is a region crucial to reward-based decision-making, and has been strongly implicated in addiction. To date, it is known that the orbitofrontal cortex encodes the subjective value of predicted rewards, but the precise mechanism by which orbitofrontal networks use value information to inform learning and choice remains unclear. One theory suggests that orbitofrontal neurons combine multiple inputs, including sensory information to compute an abstract value, so that stimulus information contributes to orbitofrontal value coding in a bottom-up fashion. Another view holds that orbitofrontal cortex makes value-related predictions that influences downstream stimulus representations in a top-down fashion. Crucially, both accounts predict that orbitofrontal neurons encode value information; the distinction lies in how that information is used at a network level. Here, we will investigate how stimulus values are processed in both local orbitofrontal networks and broader functional circuits. To assess local network properties, we will use acute neurophysiology approaches in awake, behaving monkeys as they perform a reward preference task. We will record both single neurons and local field potentials, signals believed to reflect underlying network-level function, and focus on spatiotemporal dynamics in local field potentials, and their relationship to value-encoding neurons. To assess large-scale functional networks, we will record electrocorticography (ECoG) signals from the brains of human patients undergoing intracranial monitoring in preparation for epilepsy surgery. Patients will be tested in a reinforcement-learning task, while we simultaneously record from orbitofrontal cortex and anatomically linked sensory areas that process the stimuli used in the learning task. Over the course of learning, we will determine how orbitofrontal value representations interact with sensory stimulus representations. Overall, this work will use translational approaches to determine how orbitofrontal value coding relates to network-level activity at multiple scales, which could lead to novel therapeutic approaches for conditions of aberrant reward processing, such as addiction disorders. In addition, this proposal offers outstanding training potential. I will benefit from the expertise of two established mentors Dr. Wallis who specializes in non-human primate neurophysiology, and Dr. Chang, a neurosurgeon and researcher specializing in functional brain mapping and ECoG in human patients. Their training will help me build an independent research program that combines multiple approaches to understand how reward processing impacts higher cognitive abilities such as learning, memory and decision-making.
 描述(由申请人证明):在长期禁欲后,渴望和复发也可以发生。在行为上,轨道上的皮层是一种基于奖励的制作,并且迄今为止已与之相关。对学习的信息仍然不清楚。级别将记录单个神经元和局部场电位,信号反映网络级别的函数,并关注局部场中的孔子动力学。 (ECOG)在制备伪造手术中,人类患者的大脑经历了颅内监测。网络级别的ES结合倍数以奖励处理会影响更高的认知能力,例如学习D决策。

项目成果

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Erin L Rich其他文献

Erin L Rich的其他文献

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{{ truncateString('Erin L Rich', 18)}}的其他基金

Mechanisms of multi-attribute decision-making
多属性决策机制
  • 批准号:
    10774849
  • 财政年份:
    2023
  • 资助金额:
    $ 13.05万
  • 项目类别:
Mesoscale dynamics underlying expectation bias in the orbitofrontal cortex
眶额皮层期望偏差的中尺度动力学
  • 批准号:
    10571994
  • 财政年份:
    2022
  • 资助金额:
    $ 13.05万
  • 项目类别:
Circuit mechanisms of self-organized cognitive strategies
自组织认知策略的回路机制
  • 批准号:
    10554344
  • 财政年份:
    2020
  • 资助金额:
    $ 13.05万
  • 项目类别:
Circuit mechanisms of self-organized cognitive strategies
自组织认知策略的回路机制
  • 批准号:
    10337212
  • 财政年份:
    2020
  • 资助金额:
    $ 13.05万
  • 项目类别:
Prefrontal Cortex Contributions to Behavior Organization
前额叶皮层对行为组织的贡献
  • 批准号:
    7488004
  • 财政年份:
    2006
  • 资助金额:
    $ 13.05万
  • 项目类别:
Prefrontal Cortex Contributions to Behavior Organization
前额叶皮层对行为组织的贡献
  • 批准号:
    7388263
  • 财政年份:
    2006
  • 资助金额:
    $ 13.05万
  • 项目类别:
Prefrontal Cortex Contributions to Behavior Organization
前额叶皮层对行为组织的贡献
  • 批准号:
    7112521
  • 财政年份:
    2006
  • 资助金额:
    $ 13.05万
  • 项目类别:

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    10711811
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    10711018
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    10711001
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    10711336
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使用患者层面的决策模型来改善酒精使用障碍治疗的使用
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