Making Friends with Yourself--A Depression Prevention Program for Adolescent Girls

与自己做朋友——青春期女孩抑郁症预防项目

• 批准号: 9550902
• 负责人: Susan Gaylord
• 金额: $ 22.8万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9550902
• 关键词: 18 year old; Adolescence; Adolescent; Adult; Anxiety; Assessment tool; Awareness; Behavioral; Caring; Clinical Trials; Cognitive; Compassion; Data; Depressive disorder; Development; Developmental Process; Education; Enrollment; Ensure; Female Adolescents; Friends; Future; Goals; Incidence; Individual; Intervention; Lead; Logistics; Longevity; Major Depressive Disorder; Manuals; Mediator of activation protein; Mental Depression; Mental Health; Mind-Body Intervention; Mindfulness Training; Obesity; Participant; Performance; Play; Population; Prevalence; Prevention program; Procedures; Protocols documentation; Public Health; Reproducibility; Research; Research Project Grants; Risk; Risk Behaviors; Schools; Shame; Sleep Disorders; Substance abuse problem; Symptoms; Testing; Thinking; Time; Training; Training Programs; Treatment Side Effects; Violence; Well in self; attentional control; base; child depression; chronic depression; depression prevention; depressive symptoms; design; experience; follow-up; healthy lifestyle; high risk population; high school; improved; innovation; instructor; mental function; mindfulness; novel; prevent; primary outcome; programs; recruit; recurrent depression; resilience; response; sample fixation; secondary outcome; success; treatment group; willingness

The prevalence of depression in adolescent populations has increased dramatically in recent years, with at least 1 in 5 adolescents experiencing a depressive disorder before they graduate high school, and many more suffering from subsyndromal symptoms. The incidence of depression over six months in high-risk groups is greater than 30%. Depression in adolescence increases risk for substance abuse, obesity, sleep disorders, poor school performance, and risky behavior. Prevention of depression at this critical developmental stage can enhance mental health and functioning throughout the lifespan, but existing behaviorally based depression- prevention programs have had low effect sizes and minimal long-term gains. An acceptable, feasible, effective, and sustainable behavioral prevention program could play a key role in enhancing mental health trajectories. Preliminary evidence from research on adult populations, as well as on adolescent developmental processes, suggests that a program involving training in mindfulness and self-compassion, designed specifically for adolescents with subsyndromal depression, could have a significant positive impact on depression prevention. This project’s primary goal is to refine and test the feasibility and acceptability of an innovative depression-prevention program, “Making Friends with Yourself” (a developmentally appropriate adaptation for adolescents, based on the adult Mindful Self-Compassion program), in comparison to an attention-control program, “Taking Care of Yourself” (involving education of healthy lifestyles), with adolescents who are experiencing subsyndromal depression. The “Making Friends with Yourself” program will target specific constructs associated with depression in adolescents, such as rumination (brooding), negative cognitive style, and shame, and would include training in mindfulness, self-kindness, and recognition and appreciation of our common humanity. Specific aims are: 1) To refine and manualize the “Making Friends with Yourself” (MFY) prevention program and a credible attention control program, “Taking Care of Yourself” (TCY); 2) To test the feasibility and acceptability of an exploratory clinical trial involving a mindful self-compassion intervention, the MFY program (treatment group) and a comparison attention-control, the TCY program, among 14-18 year old adolescents with subsyndromal depression; 3) To explore primary and secondary outcomes and mediators in response to the MFY Program, including incident depression (primary outcome), resilience and change in depressive symptoms (secondary outcomes); and rumination, negative cognitive style, and shame (potential mediators). This project represents a high programmatic priority for NCCIH and could lead to a large scale trial with significant impact in preventing clinical depression among adolescents.

近年来，青少年群体中抑郁症的患病率急剧上升， 至少五分之一的青少年在高中毕业之前患有抑郁症，还有更多 患有亚综合征症状的高危人群六个月以上的抑郁症发病率是 超过 30% 的青春期抑郁症会增加药物滥用、肥胖、睡眠障碍的风险， 在这个关键的发展阶段，不良的学习成绩和危险的行为可以预防抑郁症。 增强整个生命周期的心理健康和功能，但现有的基于行为的抑郁症 预防计划的效果较小，长期收益也很小，是可接受的、可行的。 有效且可持续的行为预防计划可以在增强心理健康方面发挥关键作用 来自成年人以及青少年发育研究的初步证据。 过程，建议设计一个涉及正念和自我同情培训的计划 特别是对于患有亚综合征抑郁症的青少年，可能会产生显着的积极影响 该项目的主要目标是完善和测试预防抑郁症的可行性和可接受性。 创新的抑郁症预防计划“与自己交朋友”（适合发展的项目） 青少年的适应，基于成人的正念自我同情计划），与 针对青少年的注意力控制计划“照顾好自己”（涉及健康生活方式的教育） “与自己交朋友”计划将针对正在经历亚综合症抑郁症的人。 与青少年抑郁症相关的特定结构，例如沉思（沉思）、消极 认知风格和羞耻感，包括正念、自我仁慈、认可和羞耻方面的训练 具体目标是： 1）完善和规范“与人交友”。 你自己”（MFY）预防计划和可靠的注意力控制计划“照顾你自己”（TCY）； 2) 测试涉及正念自我慈悲的探索性临床试验的可行性和可接受性 干预，MFY 计划（治疗组）和比较注意力控制，TCY 计划， 14-18 岁患有亚综合征抑郁症的青少年；3) 探讨主要和次要结果 以及针对 MFY 计划的调解员，包括事件抑郁症（主要结果）、复原力 抑郁症状的变化（次要结果）；以及沉思、消极认知风格和 （潜在的调解人）。该项目对 NCCIH 来说是一个高度计划性的耻辱，并可能导致 一项对预防青少年临床抑郁症具有重大影响的大规模试验。