Training and Education Program

培训和教育计划

• 批准号: 9038102
• 负责人: William Richard McCombie
• 金额: $ 3.24万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-25 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9038102
• 关键词: 3-Dimensional; Address; Affect; African; Area; Attention; Awareness; Basic Science; Behavior; Biological; Biological Markers; Biomedical Research; Cancer Biology; Cancer Center at Cold Spring Harbor Laboratory; Cancer Research Project; Caring; Characteristics; Clinic; Clinical; Clinical Data; Clinical Research; Collection; Colon Carcinoma; Colorectal Cancer; Communities; Community Health Education; Community Outreach; Community Practice; Computational Science; Consensus; Controlled Vocabulary; Core Biopsy; Coupled; Data; Data Element; Data Set; Development; Development Plans; Disease; Doctor of Philosophy; Drug Delivery Systems; Education; Effectiveness; Emerging Technologies; Environment; Exhibits; Exposure to; Faculty; Funding; Genetic; Genomics; Goals; Grant; Human; Incidence; Individual; Institution; Knowledge; Laboratories; Link; Malignant Neoplasms; Malignant neoplasm of pancreas; Medical; Mentors; Mentorship; Methods; Minority Groups; Modeling; Molecular Target; Molecular and Cellular Biology; NCI Scholars Program; NCI-Designated Cancer Center; Organoids; Outcome; Pancreas; Patients; Peer Review; Pharmaceutical Preparations; Phenotype; Population; Population Heterogeneity; Procedures; Publications; Research; Research Activity; Research Personnel; Research Project Grants; Research Training; Resources; Science; Scientist; Solutions; Specimen; Stem cells; Students; Technology; Testing; Toxic effect; Training; Training Programs; Training and Education; Training and Infrastructure; Translating; Translational Research; Tumor Biology; Underrepresented Minority; Underrepresented Students; Underserved Students; Vocabulary; anticancer research; base; bench to bedside; biobank; biomedical informatics; cancer care; cancer health disparity; care delivery; career; cohort; cost; design; doctoral student; drug development; empowered; epigenetic profiling; epigenomics; ethnic minority population; experience; graduate medical education; graduate student; health disparity; high risk; imaging biomarker; improved; innovation; interest; medically underserved; mortality; oncology; outreach program; patient population; precision oncology; programs; racial and ethnic; racial/ethnic difference; success; theories; translational medicine; treatment strategy; tumor

ABSTRACT Two SUNY medical campuses (SUNY Stony Brook and SUNY Downstate) serving underrepresented minority communities with cancer health disparities are partnering with the NCI designated Cancer Center at the Cold Spring Harbor Laboratories to evaluate biological and genetic differences in GI cancers (colorectal and pancreatic) that may link to differences in cancer incidence and outcome observed in racial and ethnic minorities (URM). For the Cancer Research Program, we aim to augment the representation of underrepresented minorities in the collection of biospecimens and linked high dimensional ‘omic datasets generated from these biospecimens. In this planning grant we plan to develop a SUNY Downstate GI Biobank that operates in parallel to the SUNY Stony Brook GI BioBank using standard operating procedures. We are planning the development of an integrative biomedical informatics platform that will link the biospecimens with longitudinal clinical data and with the data generated from these specimens. An initial step in the planning procedure is to develop a consensus of what data elements to include and for developing a controlled vocabulary. To increase community participatory research among racial and ethnic minority populations,we plan to leverage the resources and expertise of the SUNY Downstate Brooklyn Health Disparities Center(led by Dr. Moro Salifu) in developing community education and outreach programs in underserved communities with a high proportion of racial and ethnic minorities. The collection of biospecimens will be driven by two pilot research projects, P1 and P2. In P1, we propose to compare genomic and epigenetic profiling of URM colon cancers with non URM colon cancers. In P2, we propose to test the feasibility of adapting an innovative 3-D method to grow pancreatic organoids (miniature pancreas) from progenitor cells (developed in Dr. Tuveson’s laboratory at CSHL) from fine needle core biopsies of human pancreatic cancers collected at the two SUNY medical campuses. We plan to compare genomic and epigenomic profiling of URM pancreatic organoids with those of non-URM organoids. For the Training and Education Program, we are committed to improving the participation of underrepresented minorities in biomedical research and in increasing awareness of health disparities among established cancer researchers. In this planning grant the two SUNY medical campuses will partner with CSHL to create an integrated doctoral certificate program Scholars in BioMedical Sciences in Cancer Health Disparities. This program is designed to engage doctoral students in translational medicine, particularly in cancer health disparities, by promoting in these students an understanding of the presentation, progression and treatment of diseases related to their area of thesis research. The track requires the addition of a clinical co-mentor to the usual student-basic science advisor team who will help guide the student's biomedical/clinical research and immerse the student in clinical experiences, vocabulary, and the overall culture of clinical research.

抽象的 纽约州立大学的两个医学校区（纽约州立大学石溪分校和纽约州立大学下州分校）为代表性不足的少数族裔提供服务 存在癌症健康差异的社区正在与 NCI 指定的 Cold 癌症中心合作 Spring Harbor Laboratories 评估胃肠道癌症（结直肠癌和癌症）的生物学和遗传差异 胰腺），这可能与少数种族和族裔中观察到的癌症发病率和结果的差异有关 (URM)。对于癌症研究计划，我们的目标是增加代表性不足的少数群体的代表性。 收集生物样本和从这些样本生成的链接高维组学数据集 在这笔规划拨款中，我们计划开发一个并行运作的纽约州立大学下州 GI 生物库。 我们正在规划使用标准操作程序向纽约州立大学石溪分校 GI 生物库进行开发。 一个综合生物医学信息学平台，将生物样本与纵向临床数据联系起来 规划程序的第一步是制定一个 就包含哪些数据元素以及开发受控词汇达成共识。 种族和族裔参与性研究，我们计划利用资源和 纽约州立大学下州布鲁克林健康差异中心（由 Moro Salifu 博士领导）在开发 在种族和种族比例较高的服务欠缺社区开展社区教育和外展计划 生物样本的收集将由两个试点研究项目 P1 和 P2 驱动。 我们建议比较 URM 结肠癌与非 URM 结肠癌的基因组和表观遗传学分析。 在 P2 中，我们建议测试采用创新的 3D 方法培养胰腺类器官的可行性 （微型胰腺）来自祖细胞（由 CSHL Tuveson 博士的实验室开发）来自细针 我们计划对在纽约州立大学两个医学院采集的人类胰腺癌核心活检进行比较。 URM 胰腺类器官与非 URM 类器官的基因组和表观基因组分析。 培训和教育计划，我们致力于提高代表性不足的少数群体的参与度 生物医学研究以及提高现有癌症研究人员对健康差异的认识。 在这项规划拨款中，纽约州立大学的两个医学校区将与 CSHL 合作创建一个综合博士生中心 癌症健康差异的生物医学学者证书计划该计划旨在。 通过促进这些领域的发展，让博士生参与转化医学，特别是癌症健康差异方面的研究 学生了解与其领域相关的疾病的表现、进展和治疗 该课程需要在通常的学生基础科学顾问的基础上增加一名临床副导师。 团队将帮助指导学生的生物医学/临床研究并使学生沉浸在临床中 经验、词汇和临床研究的整体文化。