Pilot 1: Genomic and epigenomic profiling of colon cancers in racial and ethnic minority patients

试点 1：少数民族患者结肠癌的基因组和表观基因组分析

基本信息

批准号：
9038100
负责人：
William Richard McCombie
金额：
$ 4.44万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-25 至 2019-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9038100
关键词：
Address African African American Archives Base Sequence Biological Blood specimen Budgets Cancer Biology Cancer Center at Cold Spring Harbor Laboratory Caucasians Clinical Code Collaborations Collection Colon Colon Carcinoma Colorectal Colorectal Cancer Communities Community Health Education Community Outreach Controlled Vocabulary County Hospitals DNA DNA Library Data Data Set Databases Diagnosis Elements Emerging Technologies Epigenetic Process Equipment and Supplies Ethnic group Excision Exhibits Feedback Formalin Gastrointestinal Neoplasms Generations Genetic Genomic DNA Genomics Grant High-Throughput Nucleotide Sequencing Human Incidence Individual Institution Laboratories Lead Leadership Link Malignant Neoplasms Maps Medical Messenger RNA Metadata Methods MicroRNAs Minority Groups Modeling Molecular Monitor NCI-Designated Cancer Center Outcome Pancreas Paraffin Embedding Patients Peripheral Blood Mononuclear Cell Pilot Projects Population Prevention Procedures Process Proteins RNA RNA library Race Research Research Infrastructure Research Personnel Research Project Grants Resolution Resources Sampling Sequence Analysis Socioeconomic Factors Specimen Staging Students Text The Cancer Genome Atlas Tissues Training Training and Education Translational Research Underrepresented Minority United States Work abstracting anticancer research base biobank biomedical informatics cancer health disparity colon cancer patients demographics differential expression epigenetic profiling epigenomics ethnic minority population exome health disparity high risk improved insight interest methylation pattern mortality outreach program prospective racial and ethnic racial/ethnic difference sample collection transcriptome sequencing tumor tumor DNA

项目摘要

ABSTRACT – PILOT RESEARCH PROJECT 1 (P1) Two SUNY medical campuses (SUNY Stony Brook and SUNY Downstate) serving underrepresented minority communities with cancer health disparities are partnering with the NCI designated Cancer Center at the Cold Spring Harbor Laboratories (CSHL) to evaluate biological and genetic differences in colorectal cancers that may link to differences in cancer incidence and outcome observed in racial and ethnic minorities. We plan to develop a SUNY Downstate GI BioBank that will greatly augment the representation of underrepresented minorities in the collection of biospecimens that will use the same standard operating procedures currently in place at the SUNY Stony Brook GI BioBank. Furthermore the clinical metadata elements collected at SUNY Downstate will be the same and utilize a common controlled vocabulary that is used by the SUNY Stony Brook GI BioBank. To increase community participatory research among racial and ethnic minority populations, we plan to leverage the resources and expertise of the SUNY Downstate Brooklyn Health Disparities Center (led by Dr. Moro Salifu) in developing community education and outreach programs in underserved communities with a high proportion of racial and ethnic minorities (>70% African Americans). In P1, we propose to generate genomic and epigenetic profiling data of colon cancers using the NCI supported CSHL Shared DNA Resource Core directed by Dr. Dick McCombie (CSHL contact PI for P1) Generating the sequencing data will provide immediate feedback to the Downstate GI BioBank with respect to monitoring Q/A for their collection efforts. This genomic and epigenomic data will be linkable to parallel microarray and RNA-Seq data generated on the same coded deidentified samples by Dr. Jennie Williams (SUNY contact PI for P1). We anticipate that making the linked datasets available on the integrated biomedical informatics platform being developed by this proposed P20 project will facilitate sharing of these extremely valuable datasets with the larger cancer research community.

摘要 – 试点研究项目 1 (P1) 纽约州立大学的两个医学校区（纽约州立大学石溪分校和纽约州立大学下州分校）为代表性不足的少数族裔提供服务存在癌症健康差异的社区正在与 NCI 指定的 Cold 癌症中心合作 Spring Harbor Laboratories (CSHL) 评估结直肠癌的生物学和遗传差异可能与在少数种族和族裔中观察到的癌症发病率和结果的差异有关。建立纽约州立大学下州 GI 生物库，这将大大增加代表性不足的群体的代表性少数人在收集生物样本时将使用目前相同的标准操作程序此外，纽约州立大学石溪分校 (SUNY Stony Brook) GI 生物库还收集了临床元数据元素。下州将是相同的，并使用纽约州立大学石溪分校使用的通用受控词汇 GI BioBank。为了增加少数族裔人口的社区参与性研究，我们计划利用纽约州立大学下州布鲁克林健康差异中心的资源和专业知识（领导作者：Moro Salifu 博士）在服务欠缺的社区制定社区教育和外展计划在 P1 中，我们建议生成高比例的种族和族裔（>70% 非裔美国人）。使用 NCI 支持的 CSHL 共享 DNA 资源获取结肠癌的基因组和表观遗传分析数据核心由 Dick McCombie 博士（CSHL P1 联系人 PI）指导生成测序数据将提供立即向 Downstate GI BioBank 反馈有关收集工作的监控 Q/A 的信息。该基因组和表观基因组数据将可链接到在 Jennie Williams 博士（纽约州立大学 P1 联系人 PI）提供了相同的编码去识别样本。使链接的数据集在正在开发的综合生物医学信息学平台上可用拟议的 P20 项目将促进与更大的癌症共享这些极其有价值的数据集研究社区。