Brain Markers of Low and High Frequency Episodic Migraine

低频和高频发作性偏头痛的大脑标志物

• 批准号: 8925927
• 负责人: DAVID BORSOOK
• 金额: $ 41.08万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8925927
• 关键词: Acute; Affect; Affective; Age; American; Amino Acids; Amygdaloid structure; Anterior; Area; Auras; Brain; Brain region; Chemicals; Chemistry; Chronic Daily Headaches; Clinical; Data; Disease; Disease Progression; Disease model; Educational Background; Emotional; Excitatory Amino Acids; Frequencies; Functional Imaging; Functional Magnetic Resonance Imaging; Future; Gender; Glutamates; Grant; Headache; Hippocampus (Brain); Image; Imaging Techniques; Individual; Insula of Reil; Lead; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Manuscripts; Measurable; Measures; Migraine; Modeling; Morphology; Names; Nature; Neural Pathways; Neurobiology; Neurologic; Neurology; Nucleus Accumbens; Pain; Patients; Prefrontal Cortex; Prevention; Productivity; Prospective Studies; Recurrence; Research; Rest; Sensory; Stimulus; Structure; Symptoms; System; Temporal Lobe; Testing; Thalamic structure; Therapeutic Intervention; Time; base; burden of illness; cognitive function; cohort; cost; experience; gamma-Aminobutyric Acid; gray matter; insight; novel; novel therapeutic intervention; prevent; relating to nervous system; response; somatosensory; white matter

DESCRIPTION (provided by applicant): Migraine is a huge clinical problem affecting over 25 million Americans and costing billions of dollars. Episodic migraine is a recurrent headache that occurs 1-14 days per month. It may occur with or without aura (focal neurological symptoms that usually develop and resolve). Most (80-95%) migraine patients remain episodic with low frequency attacks (1-4 attacks per month) throughout their lives whereas some (about 5%) progress from low to high frequency and then to daily headache/migraine. One of the unsolved mysteries of the disease is the nature of how the brain changes in progressing from the low frequency (LF) episodic manifestation to the more frequent high frequency (HF) or chronic daily headache. Here we propose to evaluate functional, morphometric (gray matter volume and white matter integrity) and chemical (measures of excitatory and inhibitory metabolites) changes in the brains of separate cohorts of LF and HF acute episodic migraineurs. Specifically we will compare these three brain measures in (1) LF migraineurs with and without aura with healthy age, gender, education level, matched controls; (2) HF migraineurs with and without aura with healthy age, gender, education level, matched controls; and (3) LF with HF migraineurs with and with out aura. We wish to test the hypothesis that with increased migraine frequency, increased excitatory amino acids and decreased inhibitory amino acids lead to alterations in brain structure and function. We have the necessary expertise in imaging, migraine neurobiology and neurology, and preliminary data for each aspect of the proposed research.

描述（由申请人提供）：偏头痛是一个巨大的临床问题，影响超过 2500 万美国人，造成数十亿美元的损失。阵发性偏头痛是一种复发性头痛，每月发生 1-14 天。它可能有或没有先兆（通常出现并消退的局灶性神经症状）。大多数（80-95%）偏头痛患者在其一生中仍呈间歇性低频率发作（每月 1-4 次发作），而一些（约 5%）偏头痛患者从低频率发展到高频率，然后发展为每日头痛/偏头痛。该疾病的未解之谜之一是大脑从低频（LF）偶发性表现到更频繁的高频（HF）或慢性每日头痛的过程中如何变化的本质。在这里，我们建议评估 LF 和 HF 急性发作性偏头痛患者的大脑功能、形态测量（灰质体积和白质完整性）和化学（兴奋性和抑制性代谢物的测量）变化。具体来说，我们将在（1）有先兆和无先兆的 LF 偏头痛患者与健康年龄、性别、教育水平、匹配对照中比较这三种大脑测量值； (2)有先兆和无先兆的心力衰竭偏头痛患者，年龄、性别、受教育程度均健康，匹配对照； (3) LF 伴 HF 偏头痛，有先兆和无先兆。我们希望检验以下假设：随着偏头痛频率的增加，兴奋性氨基酸增加和抑制性氨基酸减少会导致大脑结构和功能的改变。我们拥有影像学、偏头痛神经生物学和神经病学方面必要的专业知识，以及拟议研究各个方面的初步数据。