Multimodal Brain Measures of Migraine with Age: Prepuberty to Adult

偏头痛随年龄的多模式脑测量：青春期前至成人

基本信息

批准号：
8422983
负责人：
DAVID BORSOOK
金额：
$ 46.48万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-01 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8422983
关键词：
4 year old Acute Adolescence Adolescent Adult Affect Age Age-Years American Anisotropy Area Basal Ganglia Biological Markers Brain Brain Chemistry Brain imaging Brain region Chemicals Chemistry Child Childhood Chronic Clinical Clinical Trials Data Development Disease Disease Progression Early Intervention Epidemiology Evaluation Family Female Functional Imaging Future Gender Glutamates Goals Hippocampus (Brain)Hormonal Hypothalamic structure Image Imaging Techniques Incidence Individual Life Magnetic Resonance Spectroscopy Measures Migraine Monitor Morphology Neurobiology Neurology Neurotransmitters Outcome Pain Patients Pharmaceutical Preparations Prevalence Prevention Process Progressive Disease Puberty Reporting Research Rest Seeds Societies Stress Structure Testing Therapeutic Intervention Thick Time Woman Workplace age group age related base boys brain morphology cohort comparative cost emerging adult gamma-Aminobutyric Acid girls gray matter independent component analysis insight male midbrain central gray substance nervous system disorder novel novel strategies prepuberty sexual dimorphism white matter young adult

项目摘要

DESCRIPTION (provided by applicant): Approximately 30 million Americans suffer from migraine headaches. Migraine is a potentially chronic, progressive disease that substantially affects patients, families, workplaces, and society. More than 20% of migraine headaches start before the age of 10 and 45% before the age of 20 and can appear in children as young as 4 years old. It has previously been considered an episodic disorder, but now is thought to be a progressive disease affecting the brain that negatively affects all aspects of an individual's life particularly during formative and productive years. Here we propose to use multimodal approaches brain imaging approaches to evaluate functional, morphometric (gray matter volume and white matter integrity) and chemical changes in the brains of cohorts of acute episodic migraineurs from 7 to 27 years of age. By approaching he problem using development (age), we propose to demonstrate: (1) that male and female migraineurs at different ages (prepubertal, pubertal, and young adult cohorts) have significantly different brain processing compared with controls; (2) that progression of brain changes may differentiate and provide novel insights into changes in the female brain during puberty/adolescence; and (3) that measures of migraine effects on the young brain (prepubertal) may provide insights into core brain changes involved in migraine independent of hormonal effects. We wish to test the hypotheses that there are age-related differences similarities in the migraine brain and that early changes may predict the long duration/course of the disease. We have the necessary expertise in imaging, migraine neurobiology and neurology, and preliminary data for each aspect of the proposed research. We expect to gain insights on how the migraine brain presents with ageing that may provide novel approaches to therapy particularly at a young age when the disease begins in a significant number of individuals.

描述（由申请人提供）：大约 3000 万美国人患有偏头痛。偏头痛是一种潜在的慢性、进行性疾病，对患者、家庭、工作场所和社会产生重大影响。超过 20% 的偏头痛在 10 岁之前开始，45% 在 20 岁之前开始，并且可能出现在年仅 4 岁的儿童中。它以前被认为是一种偶发性疾病，但现在被认为是一种影响大脑的进行性疾病，会对个人生活的各个方面产生负面影响特别是在性格形成和富有成效的时期。在这里，我们建议使用多模态脑成像方法来评估 7 至 27 岁急性发作性偏头痛患者的大脑功能、形态测量（灰质体积和白质完整性）和化学变化。通过利用发育（年龄）来解决问题，我们建议证明：（1）不同年龄（青春期前、青春期和青年群体）的男性和女性偏头痛患者与对照组相比，具有显着不同的大脑处理过程； (2) 大脑变化的进展可能会区分青春期/青春期女性大脑的变化，并提供新的见解； (3) 测量偏头痛对年轻大脑（青春期前）的影响可能有助于了解偏头痛所涉及的核心大脑变化，而与荷尔蒙的影响无关。我们希望检验这样的假设：偏头痛大脑中存在与年龄相关的差异相似性，并且早期变化可以预测疾病的长期持续时间/病程。我们拥有影像学、偏头痛神经生物学和神经病学方面必要的专业知识，以及拟议研究各个方面的初步数据。我们希望深入了解偏头痛大脑如何随着衰老而出现，这可能会提供新的治疗方法，特别是在很多人都患有这种疾病的年轻时期。