Oxygenation Fingerprinting with MRI for Ischemic Stroke

缺血性中风的 MRI 氧合指纹图谱

• 批准号: 8684656
• 负责人: Gregory George Zaharchuk
• 金额: $ 24.08万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8684656
• 关键词: Acute; Attention; Biological Markers; Blood; Blood Volume; Brain; Brain Neoplasms; Caring; Cell Death; Cerebrum; Chronic; Clinical; Complement; Decision Making; Development; Dictionary; Diffusion; Diffusion weighted imaging; Disease; Edema; Event; Failure; Fingerprint; Functional Magnetic Resonance Imaging; Gases; Growth; Hemoglobin; Hypoxia; Image; Injury; Ischemia; Ischemic Stroke; Learning; Lesion; Light; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methodology; Methods; Modeling; Motivation; Multiple Sclerosis; Natural History; Neurodegenerative Disorders; Noise; Outcome; Oxygen; Patient Triage; Patients; Performance; Perfusion; Phase; Physiological; Pilot Projects; Plague; Positron-Emission Tomography; Predisposition; Protocols documentation; Recruitment Activity; Relaxation; Reperfusion Therapy; Role; Scanning; Selection Criteria; Signal Transduction; Steno; Stroke; Superior sagittal sinus; Techniques; Testing; Tissues; Triage; Weight; Work; acute stroke; base; blood oxygen level dependent; cohort; deoxyhemoglobin; high reward; high risk; improved; insight; interest; nervous system disorder; novel strategies; prospective; public health relevance; research study; tissue oxygenation

DESCRIPTION (provided by applicant): MOTIVATION One of the central events in acute ischemic stroke is the decrease in delivery of oxygen to the brain, which leads to cell death and irreversible injury. To counteract this, the brain has mechanisms to increase its extraction of oxygen from the arterial blood, which can be imaged with oxygen-15 positron emission tomography (PET). Some evidence from PET exists that suggests that regions with increased oxygen extraction fraction (OEF) are particularly vulnerable in ischemic stroke. Given the sensitivity of MRI to paramagnetic deoxy- hemoglobin (the basis of the BOLD effect), it is possible to image tissue oxygen saturation (SO2). The motivation for the current study is to implement and validate two promising MR oxygenation methods, multiparametric quantitative BOLD and MR oxygenation fingerprinting for use in stroke patients. This latter technique builds on pioneering work extending the fingerprinting approach from anatomical to physiological imaging. AIMS AND METHODS Over a two-year period, we aim to perform studies to validate the performance of both of these MR oxygenation imaging protocols in normal subjects exposed to inspired gas challenges that will alter the global brain oxygenation. We will then apply the best of these two techniques to a cohort of acute ischemic stroke patients to determine the performance of the oxygenation-diffusion (O2- DWI) mismatch as a potential improved substitute for the traditional DWI-PWI mismatch. SIGNIFICANCE We believe successful attainment of these aims will markedly improve acute stroke care by validating a non-invasive MRI-based method to assess tissue oxygenation. We believe that there will be wide-reaching benefits to the development of a robust MR oxygenation method in a wide range of other neurological diseases, including carotid steno-occlusive disease, brain tumors, multiple sclerosis, and neurodegenerative disease.

描述（由申请人提供）： 动机 急性缺血性中风的核心事件之一是向大脑输送氧气的减少，这会导致细胞死亡和不可逆的损伤。为了解决这个问题，大脑有机制增加从动脉血中提取氧气，这可以通过氧 15 正电子发射断层扫描 (PET) 进行成像。 PET 的一些证据表明，氧提取分数 (OEF) 增加的区域特别容易发生缺血性中风。鉴于 MRI 对顺磁性脱氧血红蛋白（BOLD 效应的基础）的敏感性，可以对组织氧饱和度 (SO2) 进行成像。当前研究的动机是实施和验证两种有前景的 MR 氧合方法，即多参数定量 BOLD 和 MR 氧合指纹识别，用于中风患者。后一种技术建立在将指纹识别方法从解剖成像扩展到生理成像的开创性工作的基础上。目标和方法 在两年的时间内，我们的目标是进行研究，以验证这两种 MR 氧合成像方案在暴露于激发气体挑战的正常受试者中的性能，这些挑战将改变整体大脑氧合。然后，我们将这两种技术中的最佳技术应用于一组急性缺血性中风患者，以确定氧合-扩散 (O2-DWI) 不匹配的性能，作为传统 DWI-PWI 不匹配的潜在改进替代品。意义 我们相信，通过验证基于非侵入性 MRI 的组织氧合评估方法，成功实现这些目标将显着改善急性中风护理。我们相信，开发强大的磁共振氧合方法将在多种其他神经系统疾病中产生广泛的益处，包括颈动脉狭窄闭塞性疾病、脑肿瘤、多发性硬化症和神经退行性疾病。