Small Animal Ultrasound Imager - Vevo 2100

小动物超声成像仪 - Vevo 2100

• 批准号: 8640699
• 负责人: Peter N. Buttrick
• 金额: $ 50.57万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8640699
• 关键词: Animal Housing; Animals; Area; Back; Basic Science; Biological Markers; Blood Vessels; Blood flow; Cardiac; Cardiology; Cells; Clinical; Collaborations; Colorado; Core Facility; Decontamination; Disease; Echocardiography; Fee-for-Service Plans; Funding; Heart; Heart failure; Human; Image; Injection of therapeutic agent; Kidney; Kidney Diseases; Lung; Measurement; Medical; Medicine; Monitor; Movement; Neoplasm Metastasis; Pathogenesis; Pediatric Hospitals; Portal vein structure; Pre-Clinical Model; Pulmonology; Renal function; Request for Proposals; Research; Research Personnel; Resolution; Rodent Model; Role; Scientist; Structure; System; Technology; Therapeutic Agents; Time; Translating; Translations; Ultrasonography; United States National Institutes of Health; Universities; Ventricular Remodeling; Visual system structure; Work; animal facility; cardiac vein; hemodynamics; human disease; instrument; meetings; metropolitan; novel; novel therapeutics; pathogen; research study; tool; tumor; Animal Housing; Animals; Area; Back; Basic Science; Biological Markers; Blood Vessels; Blood flow; Cardiac; Cardiology; Cells; Clinical; Collaborations; Colorado; Core Facility; Decontamination; Disease; Echocardiography; Fee-for-Service Plans; Funding; Heart; Heart failure; Human; Image; Injection of therapeutic agent; Kidney; Kidney Diseases; Lung; Measurement; Medical; Medicine; Monitor; Movement; Neoplasm Metastasis; Pathogenesis; Pediatric Hospitals; Portal vein structure; Pre-Clinical Model; Pulmonology; Renal function; Request for Proposals; Research; Research Personnel; Resolution; Rodent Model; Role; Scientist; Structure; System; Technology; Therapeutic Agents; Time; Translating; Translations; Ultrasonography; United States National Institutes of Health; Universities; Ventricular Remodeling; Visual system structure; Work; animal facility; cardiac vein; hemodynamics; human disease; instrument; meetings; metropolitan; novel; novel therapeutics; pathogen; research study; tool; tumor

DESCRIPTION (provided by applicant): This proposal requests funds for the acquisition of a state-of-the-art Vevo2100 high-resolution ultrasound imaging system (Visual Sonics). This system would be integrated into and managed by the Small Animal Hemodynamic (SAH) Core facility within the Division of Cardiology/Department of Medicine at the University of Colorado Denver Anschutz Medical Campus (AMC). Due to the highly advanced technology of the Vevo2100, this system would significantly expand the current capabilities of the SAH Core and would enhance on-going, system-wide collaborations at the University of Colorado. A major focus of research in the Division of Cardiology is on translating findings made in pre-clinical models into novel therapeutics for the treatment of heart failure in humans. In addition, we collaborate closely with research groups in the Divisions of Renal Disease and Pulmonology to understand the role of heart: kidney and heart: lung cross-talk in the pathogenesis of cardiorenal disease and pulmonary vascular/right ventricular remodeling. More recently, we have initiated collaborations focused on tumor metastasis, biomarker discovery and contrast imaging in rodent models (see Figure). All of these efforts would benefit from the acquisition of a Vevo2100, which would enable non-invasive, longitudinal measurements of cardiac structure and function, renal and pulmonary blood flow and tumor formation in rodent models. In addition, this high-definition ultrasound system would provide an invaluable tool for monitoring localized delivery of cells and therapeutic agents via intra-cardiac or portal vein injection. The Vevo2100, which has many features in common of clinical instruments, would have a tremendous impact on NIH-funded research at the University of Colorado, and has the potential to facilitate translation of basic science discoveries into novel treatments for human disease. In addition to the aforementioned collaborations, through fee-for-service arrangements, the SAH Core serves a diverse group of investigators, not only on the AMC campus, which has two separate animal facilities, but also in the Colorado Children's Hospital and University of Colorado Boulder. For all of these studies we employ a single Vevo770 instrument (VisualSonics), which is located in a pathogen- free animal facility in Research Center II (RCII). We frequently receive requests for ultrasound assistance from investigators who house animals in other buildings or off-campus. Since these investigators are not allowed to transfer animals into the RCII facility, we attempt to accommodate them by moving the Vevo770 to an SAH Core- dedicated room within the Division of Cardiology. Unfortunately, this room is not pathogen-free, and thus movement of the instrument back to the animal facility requires extensive decontamination, resulting in at least one week of ultrasound down- time. With the acquisition of a Vevo2100, we would be able to dedicate the Vevo770 instrument to experiments for investigators who house animals in other buildings. Thus, in addition to the technological advances of the Vevo2100 that will enhance our work, having a second ultrasound instrument will enable us to meet the increasing demands for echocardiography from scientists throughout the greater Denver metropolitan area.

描述（由申请人提供）：该提案要求获得资金以获取最先进的VEVO2100高分辨率超声成像系统（Visual Sonics）。该系统将在科罗拉多州丹佛分校Anschutz Medical Campus（AMC）的心脏病学/医学系中的小型动物血流动力学（SAH）核心设施中纳入和管理。由于VEVO2100的高级技术，该系统将大大扩展SAH核心的当前功能，并可以增强科罗拉多大学持续的，全系统的合作。心脏病学划分的主要研究重点是将临床前模型中的发现转化为治疗人类心力衰竭的新型治疗剂。此外，我们与肾脏疾病和肺部学分裂的研究小组紧密合作，以了解心脏的作用：肾脏和心脏：肺部交叉言论在心脏疾病的发病机理以及肺血管/右心室重塑中。最近，我们启动了集中在啮齿动物模型中的肿瘤转移，生物标志物发现和对比成像的合作（见图）。所有这些努力将受益于获取VEVO2100，这将使心脏结构和功能，肾脏和肺血流以及啮齿动物模型中的肾脏结构和功能，肾脏和肺部血流以及肿瘤形成。此外，这种高清超声系统将为通过心脏内或门静脉注射监测细胞和治疗剂的局部递送提供宝贵的工具。 VEVO2100具有许多共同特征的临床工具，将对科罗拉多大学的NIH资助的研究产生巨大影响，并有可能促进将基础科学发现转化为新型人类疾病治疗方法。除了上述合作，通过收费服务安排，SAH核心还为一组不同的调查人员服务，不仅在AMC校园里，该校园有两个独立的动物设施，而且在科罗拉多州儿童医院和科罗拉多大学的科罗拉多大学。对于所有这些研究，我们采用了单个VEVO770仪器（Visualsics），该仪器位于研究中心II（RCII）的病原体中。我们经常收到在其他建筑物或校外容纳动物的调查人员的超声援助请求。由于这些调查人员不允许将动物转移到RCII设施中，因此我们试图通过将VEVO770移至心脏病学划分内的SAH核心专用房间来容纳它们。不幸的是，这个房间并非没有病原体，因此仪器回到动物设施需要广泛的净化，导致至少一周的超声波停机时间。通过收购VEVO2100，我们将能够将VEVO770仪器献给实验，以实验在其他建筑物中容纳动物的调查人员。因此，除了将增强我们工作的VEVO2100的技术进步外，拥有第二种超声仪器还可以使我们能够满足大丹佛大都市地区整个科学家对超声心动图的日益增长的需求。