Insulin Resistance in Childhood

童年时期的胰岛素抵抗

基本信息

批准号：
8010720
负责人：
SILVA A ARSLANIAN
金额：
$ 2.5万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-02-15 至 2011-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8010720
关键词：
Adolescent Adult Area Award Cardiovascular Diseases Child Childhood Collaborations Development Diabetes Mellitus Doctor of Medicine Doctor of Philosophy Education Endocrine Faculty Foundations Funding Grant Growth and Development function Institution Insulin Resistance Leadership Lipids Medical Students Medical center Mentors Metabolic Marker Mission Morbidity - disease rate Non-Insulin-Dependent Diabetes Mellitus Pediatric Hospitals Pediatrics Pharmacologic Substance Preventive Intervention Public Health Research Research Personnel Research Support Role SECTM1 gene Scanning Skeletal Muscle Testing The Sun Thigh structure Training United States National Institutes of Health Universities Weight Wellness Center X-Ray Computed Tomography in vivo innovation insulin sensitivity medical schools member obesity in children patient oriented research pediatrician peer

项目摘要

This is a competing renewal application for a K24 in patient-oriented research (POR) for Silva Arslanian, M.D. of the Children's Hospital University of Pittsburgh, School of Medicine. The applicant's original award provided support for POR for investigating insulin resistance during childhood growth and development, mentoring of junior faculty and fellows, advancing the research in new directions, and leadership in POR locally, nationally, and internationally. All of these aims have been executed with outstanding rigor, and the candidate has been successful in accomplishing the following: 1) Competitively renewed her R01 (2R01 HD027503); 2) Obtained new independent NIH funding as PI (1U01 DK063704), and funding for several pharmaceutical trials; 3) Advanced her mentoring commitment by obtaining new funding as PI for a felllow training grant (T32 DK63686) and junior faculty development grant (K12 DK63704), both in pediatric diabetes; 4) Established new collaborations in POR at her own institution (1R01- HD38425, and 5U01 DK061230; PI, Marsha Marcus, Ph.D.) and with other academic institutions (1R01 DK071485; PI, Shumei Sun, Ph.D., Wright State University); 5) Competitively renewed the GCRC grant (5M01RR00084), with an outstanding score, at Children's Hospital of Pittsburgh, where she is director; 6) Became a board member of the Endocrine Fellows Foundation, a national organization whose primary and sole mission is the education and research support of endocrine fellows nationally; 7) Increased the pool of pediatrician investigators in POR by attracting and mentoring new fellows/faculty from within and outside the institution; 9) Assumed a leadership role in directing the newly founded Weight Management & Wellness Center (WMWC) at Children's Hospital of Pittsburgh; and, last but not least, received the inaugural University of Pittsburgh Medical Center Richard L. Day Endowed Chair in Pediatrics. This renewal application proposes to: 1) Continue the leadership of the PI in POR in the area of childhood obesity, insulin resistance, type 2 diabetes, and cardiovascular disease, major public health problems of this millennium; 2) Provide ongoing mentoring to junior faculty, fellows, and medical students; and 3) To conduct innovative research in childhood insulin resistance, its causes, complications and control strategies. Support for these activities will enable Dr. Arslanian to further strengthen and expand the research scope of childhood obesity and insulin resistance but, more importantly, contribute to the academic development of young and upcoming clinician-investigators who will contribute to the global childhood obesity control by developing new paradigms of intervention, prevention and treatment.

这是 Silva Arslanian 在以患者为导向的研究 (POR) 中 K24 的竞争性更新申请，匹兹堡大学医学院儿童医院医学博士。申请人的原始奖项为 POR 调查儿童生长和发育期间的胰岛素抵抗提供支持，指导初级教师和研究员，推动新方向的研究，并在 POR 中发挥领导作用本地、国家和国际。所有这些目标都得到了极其严格的执行，而且候选人已成功完成以下任务： 1) 有竞争力地更新她的 R01 (2R01 HD027503); 2) 作为 PI (1U01 DK063704) 获得新的独立 NIH 资助，并资助多项药物试验； 3）通过为同事获得新的资金作为 PI 来推进她的指导承诺儿科培训补助金（T32 DK63686）和初级教师发展补助金（K12 DK63704）糖尿病; 4) 在她自己的机构（1R01-HD38425和5U01）建立了新的POR合作 DK061230； PI，Marsha Marcus，博士）以及其他学术机构（1R01 DK071485；PI，Shumei）孙博士，莱特州立大学）； 5) 竞争性地更新 GCRC 拨款 (5M01RR00084)，她在匹兹堡儿童医院担任主任，成绩优异； 6) 成为董事会成员内分泌研究员基金会，一个全国性组织，其主要和唯一的使命是教育以及全国内分泌研究员的研究支持； 7) 增加了儿科医生调查员的数量 POR 通过吸引和指导机构内外的新研究员/教员； 9）假设在指导新成立的体重管理与健康中心 (WMWC) 方面发挥领导作用匹兹堡儿童医院；最后但并非最不重要的一点是，获得了首届匹兹堡大学医学中心理查德·戴伊 (Richard L. Day) 儿科讲座教授。本次续展申请旨在： 1) 继续 PI 在 POR 领域的领导地位儿童肥胖、胰岛素抵抗、2型糖尿病、心血管疾病等重大公共卫生本世纪的问题； 2) 为初级教师、研究员和医学生提供持续的指导； 3) 对儿童胰岛素抵抗、其原因、并发症和控制进行创新研究策略。对这些活动的支持将使 Arslanian 博士能够进一步加强和扩大儿童肥胖和胰岛素抵抗的研究范围，但更重要的是，对学术做出贡献培养年轻和即将到来的临床医生研究人员，他们将为全球儿童做出贡献通过开发新的干预、预防和治疗范式来控制肥胖。