Postdoctoral Research Training in Pediatric Clinical Pharmacology

儿科临床药理学博士后研究培训

• 批准号: 8843495
• 负责人: DAVID Alastair FLOCKHART
• 金额: $ 18.4万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8843495
• 关键词: Childhood; Clinical Pharmacology; Research Training

DESCRIPTION (provided by applicant): A critical need exists for a robust supply of clinician scientists with formal training in pediatric clinical pharmacology. Without trained investigators the goal of optimizing use of medications for individual children cannot be realized. The Indiana University Department of Pediatrics and Division of Clinical Pharmacology are uniquely positioned to address this need. A strong, well-established group of clinical pharmacology investigators has the advantage of being located directly adjacent to one of the strongest pediatric research environments in the US: Riley Hospital for Children, with a Department of Pediatrics consistently ranked in the top 10 in NIH funding. This application seeks to establish a formal pediatric clinical pharmacology and therapeutics training program in parallel with our long-standing clinical pharmacology training program, which has a track record of excellence in training successful translational clinician scientists. There are three main components to the Indiana University Postdoctoral Research Training in Pediatric Clinical and Developmental Pharmacology: 1) completion of a two to three year formal didactic curriculum, at the end of which the trainee may receive a master's degree in clinical research; 2) organized pediatric participation in a personalized therapeutics seminar series and weekly journal club; and 3) active involvement in pediatric therapeutics research under the mentorship of one of the faculty members associated with the program. The program faculty selects trainees for the 2 to 3 year program based on their potential as clinician scientists from candidates with MD or MD/ PhD degrees who qualify for primary specialty certification. Exceptional PhD or PharmD candidates with experience and goals related to the objectives of the program may be selected. We propose supporting a total of three postdoctoral fellows at any given time. Those who complete the program will develop core competencies in clinical and translational research methods, biostatistics, clinical trials, research ethics, scientific writing, and grant writing. They will also be provided with a structured research mentoring program with an explicit timeline and benchmarks. In depth training focusing on pharmacokinetics, pharmacogenomics, drug development, individualized therapeutics, and clinical trial design is included in a didactic lecture series required of all trainees. Trainees may also participate in the Clinical Investigator Training Enhancement program supported by the Indiana CTSI and resulting in an MS in Clinical Investigation. Coursework combined with supervised research experience will result in development of a highly trained cadre of investigators with broad, deep, cutting edge training experiences preparing them for successful careers in pediatric clinical and translational pharmacology. The large, diverse patient population at Riley Hospital coupled with the depth, breadth and flexibility imparted by a large, cutting edge Clinical Pharmacology training program and the Wells Center for Pediatric Research offer an exceptional opportunity to study pediatric clinical pharmacology within a focused training program designed to generate leaders in this emerging field.

描述（由申请人提供）：迫切需要大量受过儿科临床药理学正规培训的临床科学家。如果没有训练有素的研究人员，优化个别儿童药物使用的目标就无法实现。印第安纳大学儿科和临床药理学部在满足这一需求方面具有独特的优势。强大、完善的临床药理学研究人员团队的优势是直接毗邻美国最强大的儿科研究环境之一：莱利儿童医院，其儿科在 NIH 资助中始终名列前 10 名。该申请旨在与我们长期的临床药理学培训计划并行建立正式的儿科临床药理学和治疗学培训计划，该计划在培训成功的转化临床医生科学家方面拥有卓越的记录。印第安纳大学儿科临床和发育药理学博士后研究培训由三个主要组成部分：1）完成两到三年的正式教学课程，培训结束后，学员可以获得临床研究硕士学位； 2) 组织儿科参与个性化治疗研讨会系列和每周期刊俱乐部； 3）在与该项目相关的一名教员的指导下积极参与儿科治疗研究。该项目的教师根据他们作为临床科学家的潜力，从具有医学博士或医学博士/博士学位且有资格获得初级专业认证的候选人中挑选参加为期 2 至 3 年的项目的学员。可能会选择具有与项目目标相关的经验和目标的优秀博士或药学博士候选人。我们建议在任何特定时间总共支持三名博士后研究员。完成该课程的学生将培养临床和转化研究方法、生物统计学、临床试验、研究伦理、科学写作和资助写作方面的核心能力。他们还将获得具有明确时间表和基准的结构化研究指导计划。所有学员都需要参加一系列教学讲座，重点关注药代动力学、药物基因组学、药物开发、个体化治疗和临床试验设计的深度培训。学员还可以参加印第安纳州 CTSI 支持的临床研究者培训增强计划，并获得临床研究硕士学位。课程作业与监督研究经验相结合，将培养一支训练有素的研究人员骨干队伍，他们拥有广泛、深入、前沿的培训经验，为他们在儿科临床和转化药理学领域的成功职业生涯做好准备。莱利医院庞大且多样化的患者群体，加上大型尖端临床药理学培训项目和威尔斯儿科研究中心所赋予的深度、广度和灵活性，为在专门设计的重点培训项目中研究儿科临床药理学提供了绝佳的机会。培养这个新兴领域的领导者。