Program in Molecular and Cellular Biosciences

分子和细胞生物科学项目

• 批准号: 8496819
• 负责人: CHERYL L MASLEN
• 金额: $ 25.01万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8496819
• 关键词: Molecular; programs

DESCRIPTION (provided by applicant): This application requests funds to support the training of predoctoral students in the Program in Molecular and Cellular Biosciences (PMCB) at Oregon Health & Science University. This interdisciplinary program brings together 156 faculty from five basic science departments (Biochemistry and Molecular Biology; Cell and Developmental Biology; Molecular and Medical Genetics; Molecular Microbiology and Immunology; and Physiology and Pharmacology), the Cancer Biology Program and affiliated research institutes to provide first- and second-year graduate students with the theoretical and laboratory foundation they require to become successful research scientists. This proposal will support stipends for 7 Ph.D. students out of the 115 currently enrolled in the PMCB for their first two years of training. The 80-member training faculty in this application are internationally recognized for their expertise in biophysical, molecular, cellular, and developmental approaches to important and compelling biological questions using state-of-the art methodologies. Notably, graduate students directly participate in ground-breaking translational research, ranging from establishment of new therapies that improve cancer survival to new insights into stem cell biology, the molecular basis of neurogenesis and energy homeostasis, protein structure and chemical biology, and vaccine development. Our program offers qualified students a common, rigorous didactic grounding for the first year and continued grounding as students begin to specialize during their second year. Students also participate in seminar series, program retreats, teaching, and may attend scientific meetings. Students must successfully pass a comprehensive written exam at the end of their first year and a qualifying exam at the end of their second year, in which they prepare and defend an original research proposal. Subsequently, students are formally admitted to one of the five participating departments to conduct a research project leading to the awarding of a Doctorate of Philosophy. Importantly, the dynamic research community at OHSU, combined with the proximity of basic and clinical research facilities, provides a unique opportunity for Ph.D. students to form cross-discipline collaborations during their training and to gain an appreciation of the health-relatedness of the basic sciences. RELEVANCE: The studies proposed in this application will provide training for first- and second-year graduate students with the theoretical and laboratory foundation they require to become successful research scientists in biomedical sciences. Trainees will learn state-of-the-art methods so that they may participate in ground-breaking basic and bench-to-bedside research that will improve the quality of healthcare in the future.

描述（由申请人提供）：本申请要求资金支持俄勒冈健康与科学大学分子和细胞生物科学项目 (PMCB) 博士前学生的培训。这个跨学科项目汇集了来自五个基础科学系（生物化学和分子生物学；细胞和发育生物学；分子和医学遗传学；分子微生物学和免疫学；以及生理学和药理学）、癌症生物学项目和附属研究机构的 156 名教员，提供第一- 以及具有成为成功研究科学家所需的理论和实验室基础的二年级研究生。该提案将支持 7 名博士的津贴。目前有 115 名学生在 PMCB 注册，接受头两年的培训。该应用程序中的 80 名培训教师因其在生物物理、分子、细胞和发育方法方面的专业知识而获得国际认可，他们使用最先进的方法来解决重要且引人注目的生物学问题。值得注意的是，研究生直接参与突破性的转化研究，从建立改善癌症生存的新疗法到对干细胞生物学、神经发生和能量稳态的分子基础、蛋白质结构和化学生物学以及疫苗开发的新见解。我们的课程为合格的学生在第一年提供通用、严格的教学基础，并在第二年为学生开始专业化提供持续的基础。学生还可以参加系列研讨会、项目静修、教学，并可以参加科学会议。学生必须在第一年末成功通过综合笔试，并在第二年末成功通过资格考试，在考试中他们要准备并捍卫原创的研究计划。随后，学生被正式录取到五个参与院系之一进行研究项目，最终获得哲学博士学位。重要的是，OHSU 充满活力的研究社区，加上邻近的基础和临床研究设施，为博士生提供了独特的机会。学生在培训期间形成跨学科合作，并了解基础科学与健康的相关性。相关性：本申请中提出的研究将为一年级和二年级研究生提供成为成功的生物医学研究科学家所需的理论和实验室基础的培训。学员将学习最先进的方法，以便他们能够参与突破性的基础研究和临床研究，从而提高未来的医疗保健质量。