Imaging and Biomarkers in Adolescents Cleared for Return to Play After Concussion

青少年脑震荡后的影像学和生物标记物可重返赛场

• 批准号: 8786483
• 负责人: PRAMOD K DASH
• 金额: $ 21.4万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8786483
• 关键词: Address; Adolescent; Anisotropy; Biological Markers; Biological Neural Networks; Blood; Brain; Brain Concussion; Brain imaging; Brain region; Cerebrum; Clinic; Clinical; Cognition; Commissure; Data Analyses; Diffusion; Diffusion Magnetic Resonance Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Guidelines; Health; Health Personnel; Impaired cognition; Injury; Licensing; Magnetic Resonance Imaging; Measures; MicroRNAs; Observational Study; Orthopedics; Plasma; Play; Post-Concussion Syndrome; Recovery; Recruitment Activity; Residual state; Rest; Serum; Severities; Sports; Sports Medicine; Structure; Telephone; Testing; cognitive function; cognitive task; comparison group; high school; imaging biomarker; meetings; neurobehavioral; prognostic; prospective; white matter

DESCRIPTION (provided by applicant): This prospective, observational study addresses the overarching hypothesis that brain dysfunction and structural injury are present at one month post- sports concussion (SC) in asymptomatic high school athletes who have been cleared by a licensed health provider (LHP) for return to play (RTP). We hypothesize that a biomarker measured from serum on the day of recruitment is prognostic of recovery by one month post-SC. High school athletes will be recruited within three days post-SC (n=24) from consecutive referrals to Memorial Hermann Sports Medicine Clinic in Houston. A comparison group of 24 high school athletes with orthopedic injury (OI) will also be recruited. Weekly assessment via telephone of post-concussion symptoms will identify athletes who are asymptomatic by one month and cleared for RTP. At one month post-injury both groups will return to clinic for neurobehavioral assessment, magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) and resting state functional magnetic resonance imaging to measure functional connectivity (FC) of brain regions. Data analysis will test between-group differences in integrity of white matter tracts (DTI) and FC of brain regions. Biomarker levels will be analyzed in relation to brain imaging and neurobehavioral recovery at one month in SC group.

描述（由申请人提供）：这项前瞻性观察性研究介绍了以下总体假设：在无症状的高中运动员中，在体育脑震荡后一个月出现了脑功能障碍和结构性损伤，这些高中运动员已被许可的健康提供商（LHP）清除（LHP）以返回发挥作用（RTP）。我们假设在招募当天从血清测量的生物标志物预后恢复了一个月。高中运动员将在SC后三天内从连续推荐到休斯敦的纪念赫尔曼运动医学诊所。还将招募24名高中运动员（OI）的比较组。每周通过脑震荡症状的电话进行每周评估，将确定一个月无症状的运动员一个月并为RTP清除。受伤后一个月，两组将返回诊所进行神经行为评估，磁共振成像（MRI），扩散张量成像（DTI）和静止状态的功能磁共振成像，以测量脑区域的功能连接性（FC）。数据分析将测试白质区域完整性（DTI）和大脑区域FC的组间差异。将分析生物标志物水平 在SC组中，在一个月的一个月内，大脑成像和神经行为恢复。