Neural circuitry underlying emotional abuse and depression in sexual minority youth

性少数青少年情绪虐待和抑郁的神经回路

基本信息

批准号：
10349004
负责人：
KRISTEN ECKSTRAND
金额：
$ 18.77万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-01 至 2027-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10349004
关键词：
Address Adolescence Adolescent Affect Affective Symptoms Age Amelia Amygdaloid structure Anisotropy Anterior Anxiety Behavior Biological Models Biometry Brain Characteristics Childhood Clinical Cognitive Communities Corpus Callosum Detection Development Diffusion Magnetic Resonance Imaging Dimensions Dorsal Environment Environmental Risk Factor Exhibits Follow-Up Studies Functional Magnetic Resonance Imaging Future Goals Heterosexuals Individual Insula of Reil Internal Capsule Intervention Knowledge Link Measurable Measures Medial Mediating Mental Depression Mental Health Mentorship Methods Minority Groups Modeling Mood Disorders Participant Perception Population Prefrontal Cortex Process Psychiatry Psychopathology Public Health Research Research Support Rewards Risk Same-sex Severities Specificity Stimulus System Testing Time Training Trauma Ventral Striatum Youth affective neuroscience associated symptom base career child depression comorbid depression comparison group depression model depressive symptoms emotional abuse experience health disparity high risk high risk population high school innovation neural circuit neuroimaging neuroregulation novel peer prevent programs recruit relating to nervous system response reward processing sex sexual minority youth social social model theories trauma exposure white matter young adult

项目摘要

PROJECT SUMMARY/ABSTRACT. Emotional abuse (EA) during childhood and adolescence is associated with greater risk and severity of depression. EA is particularly common among sexual minority youth (SMY; individuals with same sex romantic identities and attractions), a population that experiences striking depression disparities. Critical knowledge gaps prevent adequate detection and treatment of depression in SMY and addressing these disparities requires rigorous research on the mechanisms underlying depression in SMY. The proposed K23 tests an innovative model integrating cognitive and social theories of depression with affective neuroscience to explore how EA impacts neural systems underlying in the low self-worth and a negative self-focus characteristic of depression. This study will use task-based functional and diffusion MRI to examine the impact of EA on reward processing neural systems (Aim 1) and self-biased processing neural systems (Aim 2), and the relationship of EA-associated changes in these systems to depression (Aim 3) in SMY. Exploratory aims will test the extent to which EA- associated changes in these neural systems, both independently and in combination, influence depression and comorbid symptoms. This research supports a critical public health need by adding to emerging biological models of depression for SMY, and will enhance understanding of how EA, a pernicious form of trauma linked to depression severity and persistence, impacts neural systems underlying depression. Such research is a first step towards identifying novel targets for detection and developing interventions to reduce depression following EA, including in SMY. The proposed will be the first in a program of research examining the influence of trauma on the adolescent brain, and understanding how trauma-associated changes relate to affective symptoms, with a focus on minority populations. To achieve this goal, the candidate will build on their expertise in SMY mental health and basic neuroimaging to receive training in the impact of trauma on developmental psychopathology, state-of-the-art neuroimaging methods, and advanced biostatistics. She has an ideal mentorship team and optimal scientific environment to provide the training necessary for her to meet her career goals. Dr. Mary Phillips is an expert in neural systems underlying mood disorders in adolescence and young adults; Dr. Erika Forbes is an expert in developmental psychopathology and the affective neuroscience of depression, which she has adapted to SMY; and Dr. Judith Cohen is an expert in the impact and clinical implications of trauma on youth mental health. Additional mentorship from consultants will provide training in the impact of trauma on the brain in youth (Dr. Ryan Herringa), state-of-the-art fMRI (Dr. Ted Satterthwaite) and dMRI (Dr. Amelia Versace) methods, and biostatistics (Dr. Dana Tudorascu). This training will prepare the candidate for a research career applying psychiatry’s understanding of neural systems, and the state-of-the-art methods available to explore them, towards addressing emerging mental health disparities in youth communities disproportionately affected by trauma, such as SMY.

项目摘要/摘要。童年和青春期的情感虐待 (EA) 与更大的风险和严重程度相关抑郁症在性少数青少年（SMY；同性浪漫的人）中尤为常见。关键知识差距），这是一个经历显着抑郁差异的人群。防止 SMY 中抑郁症的充分检测和治疗，解决这些差异需要对 SMY 抑郁症机制的严格研究提出的 K23 测试了一项创新。利用情感神经科学对抑郁症的认知整合和社会理论进行建模，以探索 EA 如何发挥作用影响低自我价值和抑郁症的消极自我关注特征的神经系统。本研究将使用基于任务的功能和扩散 MRI 来检查 EA 对奖励处理的影响神经系统（目标 1）和自偏置处理神经系统（目标 2），以及 EA 相关的关系 SMY 中这些系统对抑郁症（目标 3）的变化将测试 EA- 的程度。这些神经系统的相关变化，无论是独立的还是组合的，都会影响抑郁症和这项研究通过增加新出现的生物症状来支持关键的公共卫生需求。 SMY 的抑郁症模型，并将加深对 EA（一种有害的创伤形式）的理解抑郁症的严重程度和持续性会影响抑郁症的神经系统，这种研究尚属首次。步骤确定新的检测目标并制定干预措施以减少抑郁症的发生 EA，包括 SMY 中的提议将是检查创伤影响的研究计划中的第一个。对青少年大脑的影响，并了解创伤相关的变化如何与情感症状相关为了实现这一目标，候选人将利用他们在 SMY 心理方面的专业知识。健康和基本神经影像学，接受有关创伤对发展精神病理学影响的培训，她拥有最先进的神经影像方法和先进的生物统计学。最佳的科学环境，为她提供实现职业目标所需的培训。埃里卡·福布斯 (Erika Forbes) 博士是青少年情绪障碍神经系统方面的专家；她是发展精神病理学和抑郁症情感神经科学方面的专家适应 SMY；朱迪思·科恩 (Judith Cohen) 博士是创伤对青少年的影响和临床意义方面的专家心理健康顾问将提供有关创伤对大脑影响的培训。青少年 (Ryan Herringa 博士)、最先进的功能磁共振成像 (Ted Satterthwaite 博士) 和 dMRI (Amelia Versace 博士) 方法和生物统计学（Dana Tudorascu 博士）。该培训将为候选人的研究生涯做好准备。应用精神病学对神经系统的理解以及可用于探索的最先进的方法他们，解决受到不成比例影响的青年社区中新出现的心理健康差异因创伤，如 SMY。