Neural circuitry underlying emotional abuse and depression in sexual minority youth

性少数青少年情绪虐待和抑郁的神经回路

• 批准号: 10349004
• 负责人: KRISTEN ECKSTRAND
• 金额: $ 18.77万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10349004
• 关键词: Address; Adolescence; Adolescent; Affect; Affective Symptoms; Age; Amelia; Amygdaloid structure; Anisotropy; Anterior; Anxiety; Behavior; Biological Models; Biometry; Brain; Characteristics; Childhood; Clinical; Cognitive; Communities; Corpus Callosum; Detection; Development; Diffusion Magnetic Resonance Imaging; Dimensions; Dorsal; Environment; Environmental Risk Factor; Exhibits; Follow-Up Studies; Functional Magnetic Resonance Imaging; Future; Goals; Heterosexuals; Individual; Insula of Reil; Internal Capsule; Intervention; Knowledge; Link; Measurable; Measures; Medial; Mediating; Mental Depression; Mental Health; Mentorship; Methods; Minority Groups; Modeling; Mood Disorders; Participant; Perception; Population; Prefrontal Cortex; Process; Psychiatry; Psychopathology; Public Health; Research; Research Support; Rewards; Risk; Same-sex; Severities; Specificity; Stimulus; System; Testing; Time; Training; Trauma; Ventral Striatum; Youth; affective neuroscience; associated symptom; base; career; child depression; comorbid depression; comparison group; depression model; depressive symptoms; emotional abuse; experience; health disparity; high risk; high risk population; high school; innovation; neural circuit; neuroimaging; neuroregulation; novel; peer; prevent; programs; recruit; relating to nervous system; response; reward processing; sex; sexual minority youth; social; social model; theories; trauma exposure; white matter; young adult

PROJECT SUMMARY/ABSTRACT. Emotional abuse (EA) during childhood and adolescence is associated with greater risk and severity of depression. EA is particularly common among sexual minority youth (SMY; individuals with same sex romantic identities and attractions), a population that experiences striking depression disparities. Critical knowledge gaps prevent adequate detection and treatment of depression in SMY and addressing these disparities requires rigorous research on the mechanisms underlying depression in SMY. The proposed K23 tests an innovative model integrating cognitive and social theories of depression with affective neuroscience to explore how EA impacts neural systems underlying in the low self-worth and a negative self-focus characteristic of depression. This study will use task-based functional and diffusion MRI to examine the impact of EA on reward processing neural systems (Aim 1) and self-biased processing neural systems (Aim 2), and the relationship of EA-associated changes in these systems to depression (Aim 3) in SMY. Exploratory aims will test the extent to which EA- associated changes in these neural systems, both independently and in combination, influence depression and comorbid symptoms. This research supports a critical public health need by adding to emerging biological models of depression for SMY, and will enhance understanding of how EA, a pernicious form of trauma linked to depression severity and persistence, impacts neural systems underlying depression. Such research is a first step towards identifying novel targets for detection and developing interventions to reduce depression following EA, including in SMY. The proposed will be the first in a program of research examining the influence of trauma on the adolescent brain, and understanding how trauma-associated changes relate to affective symptoms, with a focus on minority populations. To achieve this goal, the candidate will build on their expertise in SMY mental health and basic neuroimaging to receive training in the impact of trauma on developmental psychopathology, state-of-the-art neuroimaging methods, and advanced biostatistics. She has an ideal mentorship team and optimal scientific environment to provide the training necessary for her to meet her career goals. Dr. Mary Phillips is an expert in neural systems underlying mood disorders in adolescence and young adults; Dr. Erika Forbes is an expert in developmental psychopathology and the affective neuroscience of depression, which she has adapted to SMY; and Dr. Judith Cohen is an expert in the impact and clinical implications of trauma on youth mental health. Additional mentorship from consultants will provide training in the impact of trauma on the brain in youth (Dr. Ryan Herringa), state-of-the-art fMRI (Dr. Ted Satterthwaite) and dMRI (Dr. Amelia Versace) methods, and biostatistics (Dr. Dana Tudorascu). This training will prepare the candidate for a research career applying psychiatry’s understanding of neural systems, and the state-of-the-art methods available to explore them, towards addressing emerging mental health disparities in youth communities disproportionately affected by trauma, such as SMY.

项目摘要/摘要。 儿童和青少年期间的情绪虐待（EA）与更大的风险和严重性有关 沮丧。 EA在性少数族裔青年中尤为普遍（SMY；与同性浪漫的人 身份和景点），一种经历抑郁症分布的人群。批判知识差距 防止对SMY中的抑郁症的足够检测和治疗，并解决这些分布需要 严格研究SMY中抑郁症的机制。拟议的K23测试了创新的 模型将抑郁症的认知和社会理论与情感神经科学结合在一起，以探索如何EA 影响低自我价值的神经元系统，抑郁症的负面自聚焦特征。 这项研究将使用基于任务的功能和扩散MRI来检查EA对奖励处理的影响 神经系统（AIM 1）和自偏处理神经系统（AIM 2）以及与EA相关的关系 这些系统的变化变为抑郁症（AIM 3）。探索目的将测试ea-的程度 这些神经系统的相关变化是独立和结合的，都会影响抑郁症和 合并症状。这项研究通过增加新兴的生物学来支持关键的公共卫生需求 SMY的抑郁模型，并将增强对EA的理解，一种有害的创伤形式 抑郁症的严重程度和持久性，会影响抑郁症的神经系统。这样的研究是第一个 迈向识别新的目标进行检测和制定干预措施，以减少抑郁症 EA，包括Smy。提出的研究将是研究创伤影响的研究计划中的第一个 在青春期的大脑上，了解创伤相关的变化与情感症状如何与 关注少数族裔。为了实现这一目标，候选人将基于他们在SMY心理方面的专业知识建立 健康和基本神经影像学接受创伤对发展心理病理学的影响的培训， 最先进的神经影像学方法和晚期生物统计学。她有一个理想的巡回团队， 最佳的科学环境，为她提供必要的培训，以实现她的职业目标。玛丽·菲利普斯博士 是青少年和年轻人的神经系统的专家； Erika Forbes博士是 她拥有的发育心理病理学和受影响的抑郁神经科学专家 适应Smy；朱迪思·科恩（Judith Cohen）博士是创伤对青年的影响和临床影响的专家 心理健康。顾问的额外心理健康将为创伤对大脑的影响提供培训 在青年（Ryan Herringa博士），最先进的FMRI（Ted Satterthwaite博士）和DMRI（Amelia Versace博士） 方法和生物统计学（Dana Tudorascu博士）。这项培训将使候选人为研究职业做好准备 应用精神病学对神经系统的理解以及可用于探索的最新方法 他们致力于解决青年社区中新出现的心理健康差异。 通过创伤，例如史密斯。