Neuroimaging mechanisms of change in psychotherapy for addictive behaviors

成瘾行为心理治疗变化的神经影像机制

基本信息

批准号：
9069478
负责人：
Tammy Chung
金额：
$ 4.92万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9069478
关键词：
Addictive Behavior Address Alcohol or Other Drugs use Alcoholism Area Attention BRAIN initiative Base of the Brain Behavior Behavior Therapy Behavioral Behavioral Mechanisms Biological Biology Brain Clinical Clinical Research Collaborations Diagnosis Effectiveness Fostering Foundations Funding Gold Guidelines Health Institutes Knowledge Learning Left Longevity Maintenance Mediating Methods Motivation National Institute on Alcohol Abuse and Alcoholism Neurosciences Outcome Participant Peer Review Population Prevention Psychology Psychotherapy Research Research Design Research Personnel Research Support Resources Science Scientist Series Societies Strategic Planning Structure Symptoms Translational Research Treatment outcome United States National Institutes of Health Work addiction alcohol abuse therapy alcohol intervention alcohol prevention behavior change behavioral response brain behavior clinical practice drinking experience improved innovation insight intervention program meetings neuroimaging new technology post intervention programs real world application research study standard care success symposium theories tool translational approach treatment effect treatment response

项目摘要

DESCRIPTION (provided by applicant): Research on mechanisms of behavior change (MOBC) provides an innovative method to improve treatment for addictive behaviors. An important extension of MOBC research involves the use of translational approaches, which examine how basic biological (i.e., brain-based mechanisms) and behavioral factors interact in initiating and sustaining positive behavior change as a result of psychotherapy. This R13 application proposes an annual conference, to be held in conjunction with the Research Society on Alcoholism meeting (RSA), on the topic of "Neuroimaging mechanisms of change in psychotherapy for addictive behaviors." Conference objectives are to (1) foster cross-disciplinary collaboration among researchers in the fields of psychotherapy and neuroscience, particularly neuroimaging, to address brain-based mechanisms of change in alcohol treatment; and (2) cover conceptual, methodological, and clinical issues relevant to the use of neuroimaging in MOBC research from clinical and neuroscience perspectives in order to build a common foundation for effective collaboration. These objectives are closely aligned with NIH and NIAAA strategic plans to support transformative translational research on the science of behavior change. We propose 3 annual conferences, each 1.5 days in duration. Each conference would include a full day focused on translational research concepts and methods, followed by a half-day held in conjunction with the on-going pre-RSA MOBC satellite, which would focus on clinical issues and real-world applications relevant to translational research efforts. The multi-year conference will cover a sequenced series of foundational topics to facilitate collaboration among clinicians and neuroscientists, and will build momentum toward sustained collaboration on MOBC research among conference participants. In Year 1, presentations would cover, for example, key concepts and methods in translational research study design. Year 2 would cover more advanced topics, such as methods for analysis of brain circuits in relation to understanding treatment response and identifying potential treatment targets. Year 3 would focus on presenting empirical findings, including discussion of "real-world" experiences in conducting translational research, and potential applications of translational research findings to clinical practice. The proposed multi-year conference aims to advance translational research on MOBC, which holds promise for understanding of how psychotherapy can modify brain structure and functioning and facilitate the initiation and maintenance of positive behavioral change.

描述（由申请人提供）：对行为变化机制的研究（MOBC）提供了一种创新的方法来改善成瘾行为的治疗方法。 MOBC研究的重要扩展是使用翻译方法，这些方法研究了基本生物学（即基于大脑的机制）和行为因素如何在启动和维持心理治疗的阳性行为改变时相互作用。该R13申请提出了一个年度会议，将与酒精中毒研究协会（RSA）共同举行，该会议是“对成瘾行为的心理治疗变化的神经影像机制”主题。会议目标是（1）促进心理治疗和神经科学领域的研究人员（尤其是神经影像学）的研究人员之间的跨学科合作，以解决酒精治疗中基于大脑的变化机制；（2）从临床和神经科学的角度来看，涵盖了与在MOBC研究中使用神经影像有关的概念，方法论和临床问题，以建立有效协作的共同基础。这些目标与NIH和NIAAA战略计划紧密相符，以支持有关行为改变科学的变革性转化研究。我们提出3次年度会议，每1.5天的持续时间。每次会议都将包括一整天，专注于翻译研究概念和方法，然后与正在进行的RSA MOBC卫星一起进行半天，该卫星将重点放在临床问题和与转化研究工作有关的现实世界中。多年的会议将涵盖一系列测序的基础主题，以促进临床医生和神经科学家之间的合作，并将建立在会议参与者之间进行MOBC研究的持续合作的动力。在第1年，演讲将涵盖翻译研究设计中的关键概念和方法。第二年将涵盖更高级的主题，例如用于分析脑电路的方法，与了解治疗反应和识别潜在的治疗靶标有关。第三年将着重于提出经验发现，包括讨论进行翻译研究中的“现实世界”经验，以及转化研究结果对临床实践的潜在应用。拟议的多年会议旨在推进对MOBC的翻译研究，该研究有望理解心理治疗如何改变大脑结构和运作，并促进积极行为改变的启动和维持。