The NYU Women's Health Study

纽约大学女性健康研究

基本信息

批准号：
8889432
负责人：
Anne Zeleniuch-Jaquotte
金额：
$ 78.83万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-01 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8889432
关键词：
Address Age Age-Years Area Biological Assay Biological Markers Blood Blood Donations Breast Breast Cancer Detection Breast Cancer Risk Factor Cardiovascular Diseases Characteristics Clinic Cohort Studies Collection Colorectal DNA Data Data Collection Databases Development Diagnosis Diet Disease Endometrial Endometrium Enrollment Epidemiology Florida Food Frequencies Funding Future Genetic Variation Glioma Goals Health Hepatic Lymphoma High Prevalence Hormonal Hormones Investigation Kidney Laboratories Life Life Style Light Location Lung Malignant Neoplasms Malignant neoplasm of pancreas Measurable Medical History MicroRNAs Molecular Neighborhoods New Jersey New York New York City Non-Hodgkin&apos s Lymphoma Obesity Obesity associated cancer Ovarian Ovary Pancreas Participant Prevention Public Health Public Policy Publications Questionnaires Reproductive History Research Infrastructure Resources Risk Risk Factors Sampling Serum Site Statistical Methods Study of serum Techniques Telephone Interviews Time Tumor Subtype Tumor Tissue Update Validation Visit Walking Woman Women&apos s Health biobank cancer risk cancer site cohort cytokine density disorder risk follow-up genome wide association study improved indexing land use malignant breast neoplasm metabolomics metropolitan neighborhood association prospective tumor tumor registry young woman

项目摘要

DESCRIPTION (provided by applicant): The NYU Women's Health Study (NYUWHS) is a prospective cohort study of 14,274 healthy women who were enrolled in 1985-1991 at a breast cancer screening clinic in New York City. In addition to data on reproductive factors, medical history and lifestyle, the study collected serum samples from all participants at enrollment. Serum samples were also collected at subsequent breast cancer screening visits from over half the women. DNA is available for all study participants. To date, the NYUWHS has led to over 170 publications, 57 since 2010. The NYUWHS has initiated or participated in studies of cancer of the breast, endometrium, colorectum, ovary, lung, pancreas, kidney, liver and non-Hodgkin lymphoma (NHL). Exposures studied include diet, reproductive factors, and circulating levels of hormones, dietary markers, cytokines, and other biomarkers. The NYUWHS also participates in genome-wide association studies of pancreatic cancer, NHL, and glioma. Finally, the NYUWHS has been funded to conduct studies on cardiovascular disease and the NYUWHS data have motivated the development of new statistical methods. The objectives of this application are to maintain and enhance the infrastructure of the study. The specific aims are to: 1) continue cancer case ascertainment through both active and passive follow-up; 2) update exposure data, including diet and outdoor walking, through follow- up questionnaires; 3) collect tumor blocks for major cancer sites (breast, colorectal, endometrial, and lung) in order to assess risk factors according to molecular subtypes; 4) collect and validate data on neighborhood walkability. The continued follow-up is expected to identify an additional 1,389 cancer cases and the collection of tumor blocks will enhance the value of the study, as will the collection of data on neighborhood walkability. The NYUWHS has several specific strengths. First, serum collected at enrollment and DNA are available for all participants, making the biorepository a valuable resource to study associations between genetic variation, biomarkers, and disease risk. Second, repeat serum samples are available for over half of the participants and are very valuable to assess and improve temporal reliability of circulating markers. Third, while several large cancer cohorts started enrollment at age 50, 6,659 NYUWHS participants were <50 years of age at enrollment/blood donation, providing opportunities for the study of cancer risk factors among younger women. Finally, New York City is a particularly well-suited location for studies of walkability because there is a wide range in walkability across different neighborhoods.

描述（由申请人提供）：纽约大学妇女健康研究（NYUWHS）是一项前瞻性队列研究，对1985 - 1991年在纽约市的一家乳腺癌筛查诊所入学的14,274名健康妇女。除了有关生殖因素，病史和生活方式的数据外，该研究还收集了所有参与者的血清样本。在随后的一半女性的乳腺癌筛查访问中还收集了血清样品。 DNA可用于所有研究参与者。迄今为止，NYUWHS已导致了170多个出版物，自2010年以来已有57个出版物。NYUWHS已启动或参与了乳腺癌，子宫内膜，结肠癌，卵巢，卵巢，肺，胰腺，肾脏，肾脏，肝脏，肝脏和非霍奇金淋巴瘤（NHL）的研究。研究的暴露包括饮食，生殖因子以及激素的循环水平，饮食标志物，细胞因子和其他生物标志物。 NYUWH还参加了胰腺癌，NHL和神经胶质瘤的全基因组关联研究。最后，NYUWH已被资助用于对心血管疾病进行研究，NYUWHS数据激发了新的统计方法的发展。该应用程序的目标是维持和增强研究的基础设施。具体目的是：1）通过主动和被动随访继续癌症病例确定； 2）通过后续问卷调查更新暴露数据，包括饮食和室外步行； 3）收集主要癌症部位（乳腺癌，结肠直肠，子宫内膜和肺）的肿瘤块，以根据分子亚型评估危险因素； 4）收集和验证有关邻里步行性的数据。预计持续的随访将确定另外1,389例癌症病例，肿瘤块的收集将提高研究的价值，有关邻里步行性数据的收集也将提高。 Nyuwhs具有多种特定的优势。首先，在入学和DNA时收集的血清均可为所有参与者提供，使生物座席成为研究遗传变异，生物标志物和疾病风险之间关联的宝贵资源。其次，重复的血清样品可用于一半以上的参与者，并且对于评估和提高循环标记的时间可靠性非常有价值。第三，虽然几个大型癌症队列在50岁开始入学，但6,659名NYUWH的参与者在入学/献血时<50岁，为研究年轻女性的癌症危险因素提供了机会。最后，纽约市是一个特别适合进行步行性研究的地方，因为在不同社区的步行性范围很广。