Advanced Multidisciplinary Training Program for Systems Biology

系统生物学高级多学科培训计划

• 批准号: 8867259
• 负责人: JAREK MELLER
• 金额: $ 16.69万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8867259
• 关键词: Systems Biology; Training Programs; multidisciplinary

DESCRIPTION (provided by applicant): In biomedical research fields, information now accumulates at a much faster rate than the paradigms and methods of classic research disciplines can effectively utilize. It is clear that discipline-specific expertise can no longer sustain adequate research progress. Emerging scientists, regardless of their breadth of training, must also be trained to work in research teams so that they can continually take advantage of new methods and concepts throughout their career. The proposed Advanced Multidisciplinary Training Program for Systems Biology is designed to prime researchers to tackle complex mechanisms of human disease utilizing cross- disciplinary approaches. There are two ways to cross disciplines. A multidisciplinary approach is team-building: experts from diverse disciplines applying their unique perspectives to address collectively a problem. In contrast, an interdisciplinary approach is when a single person applies knowledge that melds two or more traditional disciplines to solve a problem. New interdisciplinary fields (and investigators) have always been created by close multidisciplinary collaboration, and our program is designed to enforce such collaborations as an essential element of graduate training. Such comprehensive training requires a program specifically suited to the needs of individual trainees that also accelerates research progress. The overall goal of the Advanced Multidisciplinary Training Program for Systems Biology is to accelerate biomedical research through cross- discipline training of pre-doctoral students. The proposed Training Program will involve 33 program faculty members and selected pre-doctoral trainees matriculated into 14 degree-granting Ph.D. programs. Selected faculty members from these Ph.D. programs participate as mentors in this training program based on their diverse research backgrounds of relevance to this training program, and potential or existing collaborative research projects to provide students with interdisciplinary training opportunities. Our objectives are to provide didactic training in interdisciplinary approaches spanning computational to biological disciplines, and create a vibrant training environment for students that is a research community composed of multidisciplinary teams and interdisciplinary scientists working together to understand the mechanisms of human disease. The objectives will be achieved by implementation of a 2-year training plan that incorporates the following features: 1) didactic and experiential training in interdisciplinary research concepts and approaches, 2) a student- centered and flexible curriculum custom tailored to meet the needs of each student via computational and biology elective courses, 3) a research project that will require the student to use interdisciplinary approaches under the mentorship of a multi-disciplinary set of faculty co-mentors, and 4) students engaged in a community that encourages interaction between students and mentors through seminars, data and journal clubs, and an annual retreat. Plans for student and program assessment are designed to tightly track student progress, and allow for continual improvement of the training program.

描述（由申请人提供）：在生物医学研究领域，现在信息积累的速度比经典研究学科的范式和方法可以有效利用的速度快得多。显然，特定学科的专业知识不再能够维持足够的研究进展。新兴科学家，无论其培训范围如何，也必须接受在研究团队中工作的培训，以便他们能够在整个职业生涯中不断利用新方法和新概念。拟议的系统生物学高级多学科培训计划旨在帮助研究人员利用跨学科方法解决人类疾病的复杂机制。跨学科有两种方式。多学科方法是团队建设：来自不同学科的专家运用他们独特的观点来共同解决问题。相比之下，跨学科方法是指一个人应用融合两个或多个传统学科的知识来解决问题。新的跨学科领域（和研究人员）始终是通过密切的多学科合作创建的，我们的项目旨在将这种合作作为研究生培训的基本要素。这种全面的培训需要专门适合个别学员需求的计划，同时也能加速研究进展。系统生物学高级多学科培训项目的总体目标是通过博士前学生的跨学科培训加速生物医学研究。拟议的培训计划将涉及 33 名计划教职人员和选定的博士前学员，他们将被录取到 14 个授予学位的博士学位项目。程序。从这些博士中选出的教员。项目根据与本培训项目相关的不同研究背景以及潜在或现有的合作研究项目作为导师参与本培训项目，为学生提供跨学科培训机会。我们的目标是提供涵盖计算到生物学科的跨学科方法的教学培训，并为学生创造一个充满活力的培训环境，这是一个由多学科团队和跨学科科学家组成的研究社区，他们共同努力了解人类疾病的机制。这些目标将通过实施为期 2 年的培训计划来实现，该计划包含以下特点：1）跨学科研究概念和方法的教学和体验式培训，2）以学生为中心的灵活课程定制，以满足每个人的需求学生通过计算和生物学选修课程，3）一个研究项目，要求学生在多学科教师共同导师的指导下使用跨学科方法，4）学生参与一个鼓励学生之间互动的社区通过研讨会、数据和期刊俱乐部以及年度静修会向学生和导师提供帮助。学生和项目评估计划旨在严格跟踪学生的进度，并持续改进培训项目。

项目成果

Na,K-ATPase α2 activity in mammalian skeletal muscle T-tubules is acutely stimulated by extracellular K+.

• DOI: 10.1085/jgp.201511407
• 发表时间: 2015-10
• 期刊: The Journal of general physiology
• 作者: DiFranco M;Hakimjavadi H;Lingrel JB;Heiny JA
• 通讯作者: Heiny JA

K⁺ and Rb⁺ Affinities of the Na,K-ATPase α₁ and α₂ Isozymes: An Application of ICP-MS for Quantification of Na⁺ Pump Kinetics in Myofibers.

• DOI: 10.3390/ijms19092725
• 发表时间: 2018-09-12
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Hakimjavadi H;Stiner CA;Radzyukevich TL;Lingrel JB;Norman N;Landero Figueroa JA;Heiny JA
• 通讯作者: Heiny JA