A novel treatment for aphasia and apraxia of speech: Measurement of outcomes

失语症和言语失用症的新型治疗方法：结果测量

• 批准号: 9001840
• 负责人: Julie L. Wambaugh
• 金额: --
• 依托单位: VA SALT LAKE CITY HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2016-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9001840
• 关键词: Acquired Aphasia; Address; Advanced Development; Aphasia; Behavior Therapy; Chronic; Clinical Research; Combined Modality Therapy; Communication; Data; Development; Disease; Future; Goals; Individual; Investigation; Language; Language Disorders; Lead; Length; Measurement; Measures; Minor; Motor; Nervous System Trauma; Neurologic; Outcome; Outcome Measure; Participant; Persons; Phase; Production; Research; Research Personnel; Response Generalization; Sampling; Severities; Speech; Speech Disorders; Speech Sound; Stimulus; Symptoms; Techniques; Testing; Time; Training; Treatment outcome; abstracting; clinical application; comparative treatment; design; follow-up; lexical; novel; phrases; public health relevance; response; skills; sound

DESCRIPTION (provided by applicant): Project Abstract Aphasia and acquired apraxia of speech (AOS) are neurogenic disorders of language and motor speech, respectively. Individually, and in combination, these disorders can significantly disrupt communication. These disorders commonly co-occur (Duffy, 2007); in particular, AOS very rarely occurs without aphasia. Despite the likelihood that persons with both AOS and aphasia will require treatment for both conditions, there has been limited research concerning treatments that may positively impact language and speech symptoms. The purpose of the proposed research is to further develop and examine the effects of a novel behavioral treatment that targets aphasia and acquired apraxia of speech (AOS) simultaneously. This treatment, Combined Aphasia and Apraxia of Speech Treatment (CAAST), combines therapy techniques from an established aphasia treatment (i.e., Response Elaboration Training; Kearns, 1985) and a well-studied AOS treatment (i.e., Sound Production Treatment; Wambaugh et al., 1998). An initial investigation of the effects of CAAST is currently being completed with four persons with chronic aphasia and AOS. Preliminary findings are promising in that substantial improvements in production of correct information units (CIUs; Nicholas & Brookshire, 1993) have been found along with improvements in sound production. A primary purpose of the proposed research is to examine outcomes of this treatment beyond the basic measures currently being utilized. An additional purpose of the planned research is to develop/evaluate speech/language measures for use with this treatment. Three investigations are planned to advance the development of CAAST. The first investigation will utilize recently collected CAAST probe data in the form of narrative discourse samples. The purpose of the investigation is to evaluate changes in language production beyond CIUs. Probes from baseline, end of treatment phases, and follow-up will be examined in terms of mean length of utterance (MLU), phrase and sentence production, lexical form class composition, and lexical diversity and novelty. The goal of the second investigation is to begin development of appropriate speech production outcome measures for use with CAAST (and AOS treatments in general). The planned study is designed to examine the effects of repeated sampling (i.e., test-retest) on the following speech production measures with a group of 30 participants with chronic AOS and aphasia: total word and sentence durations, number of fluent utterances, and percent consonants correct. The third planned investigation will be a systematic replication of the on-going CAAST study. CAAST will be administered to four additional persons with aphasia and AOS with outcome measures derived from the first two planned investigations. The products of the proposed research will be a refined version of CAAST with appropriate, reliable speech and language outcome measures; the treatment and accompanying outcome measures are expected to have clinical and research utility.

描述（由申请人提供）： 项目摘要 失语症和获得性言语失用症 (AOS) 分别是语言和运动言语的神经源性障碍。这些疾病单独或组合起来都会严重扰乱沟通。这些疾病通常同时发生（Duffy，2007）；特别是，AOS 很少会出现不失语的情况。尽管同时患有 AOS 和失语症的人可能需要针对这两种情况进行治疗，但有关可能对语言和言语症状产生积极影响的治疗的研究仍然有限。 拟议研究的目的是进一步开发和检查同时针对失语症和获得性言语失用症（AOS）的新型行为治疗的效果。这种失语症和言语失用症联合治疗 (CAAST) 结合了现有失语症治疗方法（即反应精细训练；Kearns，1985）和经过充分研究的 AOS 治疗方法（即声音产生治疗；Wambaugh 等人） .，1998）。 目前正在对四名慢性失语症和 AOS 患者进行 CAAST 效果的初步调查。初步发现是有希望的，因为随着声音生产的改进，正确信息单位的生产（CIU；Nicholas & Brookshire，1993）也得到了显着的改进。拟议研究的主要目的是除了目前使用的基本措施之外，检查这种治疗的结果。计划研究的另一个目的是开发/评估用于这种治疗的言语/语言测量。计划开展三项调查来推动CAAST的发展。 第一项调查将利用最近收集的 CAAST 调查数据（以叙事话语样本的形式）。调查的目的是评估 CIU 之外语言产生的变化。来自基线、治疗阶段结束和后续阶段的探索将根据平均话语长度 (MLU)、短语和句子产生、词汇形式类别构成以及词汇多样性和新颖性进行检查。 第二项调查的目标是开始开发适当的言语产生结果测量，用于 CAAST（以及一般的 AOS 治疗）。计划中的研究旨在检查重复抽样（即重测）对 30 名患有慢性 AOS 和失语症参与者的以下言语产生测量的影响：单词和句子的总时长、流利话语的数量和百分比辅音正确。第三项计划调查将是正在进行的 CAAST 研究的系统复制。 CAAST 将对另外 4 名患有失语症和 AOS 的患者进行，其结果测量来自前两项计划的调查。 拟议研究的产品将是 CAAST 的改进版本，具有适当、可靠的语音和语言结果测量；治疗和伴随的结果测量预计具有临床和研究用途。