A novel treatment for aphasia and apraxia of speech: Measurement of outcomes

失语症和言语失用症的新型治疗方法：结果测量

• 批准号: 9001840
• 负责人: Julie L. Wambaugh
• 金额: --
• 依托单位: VA SALT LAKE CITY HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2016-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9001840
• 关键词: Acquired Aphasia; Address; Advanced Development; Aphasia; Behavior Therapy; Chronic; Clinical Research; Combined Modality Therapy; Communication; Data; Development; Disease; Future; Goals; Individual; Investigation; Language; Language Disorders; Lead; Length; Measurement; Measures; Minor; Motor; Nervous System Trauma; Neurologic; Outcome; Outcome Measure; Participant; Persons; Phase; Production; Research; Research Personnel; Response Generalization; Sampling; Severities; Speech; Speech Disorders; Speech Sound; Stimulus; Symptoms; Techniques; Testing; Time; Training; Treatment outcome; abstracting; clinical application; comparative treatment; design; follow-up; lexical; novel; phrases; public health relevance; response; skills; sound

DESCRIPTION (provided by applicant): Project Abstract Aphasia and acquired apraxia of speech (AOS) are neurogenic disorders of language and motor speech, respectively. Individually, and in combination, these disorders can significantly disrupt communication. These disorders commonly co-occur (Duffy, 2007); in particular, AOS very rarely occurs without aphasia. Despite the likelihood that persons with both AOS and aphasia will require treatment for both conditions, there has been limited research concerning treatments that may positively impact language and speech symptoms. The purpose of the proposed research is to further develop and examine the effects of a novel behavioral treatment that targets aphasia and acquired apraxia of speech (AOS) simultaneously. This treatment, Combined Aphasia and Apraxia of Speech Treatment (CAAST), combines therapy techniques from an established aphasia treatment (i.e., Response Elaboration Training; Kearns, 1985) and a well-studied AOS treatment (i.e., Sound Production Treatment; Wambaugh et al., 1998). An initial investigation of the effects of CAAST is currently being completed with four persons with chronic aphasia and AOS. Preliminary findings are promising in that substantial improvements in production of correct information units (CIUs; Nicholas & Brookshire, 1993) have been found along with improvements in sound production. A primary purpose of the proposed research is to examine outcomes of this treatment beyond the basic measures currently being utilized. An additional purpose of the planned research is to develop/evaluate speech/language measures for use with this treatment. Three investigations are planned to advance the development of CAAST. The first investigation will utilize recently collected CAAST probe data in the form of narrative discourse samples. The purpose of the investigation is to evaluate changes in language production beyond CIUs. Probes from baseline, end of treatment phases, and follow-up will be examined in terms of mean length of utterance (MLU), phrase and sentence production, lexical form class composition, and lexical diversity and novelty. The goal of the second investigation is to begin development of appropriate speech production outcome measures for use with CAAST (and AOS treatments in general). The planned study is designed to examine the effects of repeated sampling (i.e., test-retest) on the following speech production measures with a group of 30 participants with chronic AOS and aphasia: total word and sentence durations, number of fluent utterances, and percent consonants correct. The third planned investigation will be a systematic replication of the on-going CAAST study. CAAST will be administered to four additional persons with aphasia and AOS with outcome measures derived from the first two planned investigations. The products of the proposed research will be a refined version of CAAST with appropriate, reliable speech and language outcome measures; the treatment and accompanying outcome measures are expected to have clinical and research utility.

描述（由申请人提供）： 项目摘要失语症和言语的失败（AOS）分别是语言和运动言语的神经源性疾病。这些疾病可以单独和结合使用，可以极大地破坏交流。这些疾病通常是同时发生的（Duffy，2007年）；特别是，AO很少发生而没有失语症。尽管患有AOS和失语症的人可能在两种情况下都需要治疗，但有关治疗的研究可能会对语言和语音症状产生积极影响。 拟议的研究的目的是进一步发展和研究一种新型行为治疗的影响，该治疗方法同时针对言语和言语失调​​（AOS）。这种治疗方法结合了言语治疗（CAST）（CAST）的结合，结合了既定的失语症治疗方法（即反应阐述培训； Kearns，1985）和经过充分研究的AOS治疗（即声音生产治疗； Wambaugh等，1998）。 目前，对四个患有慢性失语和AOS的人正在完成对CAAST影响的初步研究。初步的发现是有希望的，因为已经发现了正确信息单元的生产（CIUS； Nicholas＆Brookshire，1993）以及声音生产的改进。拟议研究的主要目的是检查目前正在使用的基本措施之外的治疗结果。计划研究的另一个目的是制定/评估与此治疗的语音/语言度量。计划进行三项调查以推动CAST的发展。 首次研究将以叙事话语样本的形式利用最近收集的CAAST探针数据。调查的目的是评估CIUS以外的语言生产变化。基线，治疗阶段结束和随访的探针将以平均话语（MLU），短语和句子的产生，词汇形式类别组成以及词汇多样性和新颖性来检查。 第二次调查的目的是开始制定适当的语音生产结果指标，以与CAST（以及一般的AOS治疗）一起使用。该计划的研究旨在检查重复采样（即重新测试）对以下语音生产度量的影响，其中30名患有慢性AOS和失语症的参与者：总单词和句子持续时间，流利的话语数量和辅音百分比正确。第三项计划的调查将是对正在进行的CAST研究的系统复制。 CAAST将对另外四个患有失语症和AOS的人进行管理，并采用了前两项计划调查得出的结果措施。 拟议研究的产品将是CAST的精致版本，并采用适当，可靠的语言和语言结果指标；预计治疗和随附的结果指标将具有临床和研究实用性。