Circuit mechanisms of auditory categorization

听觉分类的电路机制

基本信息

批准号：
8484818
负责人：
ANTHONY M ZADOR
金额：
$ 38.15万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2017-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8484818
关键词：
Animals Architecture Area Auditory Auditory area Auditory system Autistic Disorder Behavior Behavioral Brain region Chronic Corpus striatum structure Decision Making Diagnosis Disease Environment Etiology Foundations Gilles de la Tourette syndrome Goals Human Investigation Laboratories Language Lead Learning Left Mediating Mental disorders Methods Modality Molecular Neural Pathways Neurons Obsessive-Compulsive Disorder Output Parkinson Disease Pathway interactions Perception Positioning Attribute Process Rattus Rewards Rodent Role Schizophrenia Sensory Signal Transduction Stimulus Testing Tinnitus Training auditory stimulus awake design extracellular flexibility improved insight nervous system disorder neural circuit neuromechanism neuropathology nonhuman primate optogenetics research study response sound therapy development tool

项目摘要

DESCRIPTION (provided by applicant): The long-term goal of our investigations is to understand how neural circuits in the auditory system underlie the processing of sound. Understanding this circuitry is likely to have an impact on the diagnosis and treatment of clinically important central neuropathologies, including autism, schizophrenia, tinnitus, Tourette's syndrome and obsessive compulsive disorder. The central goal of this proposal is to understand how the output of the auditory cortex is used by downstream areas to effect behavior. In Aim 1 we use electrophysiological methods to study responses in the auditory cortex and target areas during a sound categorization task. In Aim 2 we use optogenetic methods to test the hypotheses that the activity of output neurons in the auditory cortex is causal in mediating behavior during the task. Finally in Aim 3, we test the hypothesis that learning to perform an auditory categorization modifies connections between neurons in their auditory cortex and their downstream targets. These studies will provide insight into how auditory cortex guides behavior, and provide a foundation for further study of role of these neurons in normal auditory function and disease, facilitating the development of treatments for psychiatric and neurological diseases.

描述（由申请人提供）：我们研究的长期目标是了解听觉系统中的神经回路如何构成声音处理的基础。了解这一回路可能会对临床上重要的中枢神经病理学的诊断和治疗产生影响，包括自闭症、精神分裂症、耳鸣、抽动秽语综合症和强迫症。该提案的中心目标是了解下游区域如何使用听觉皮层的输出来影响行为。在目标 1 中，我们使用电生理学方法来研究声音分类任务期间听觉皮层和目标区域的反应。在目标 2 中，我们使用光遗传学方法来测试以下假设：听觉皮层中的输出神经元的活动与任务期间的调解行为有关。最后，在目标 3 中，我们测试了这样一个假设：学习进行听觉分类会改变听觉皮层神经元与其下游目标之间的连接。这些研究将深入了解听觉皮层如何引导行为，并为进一步研究这些神经元在正常听觉功能和疾病中的作用提供基础，从而促进精神和神经疾病治疗方法的开发。