9th International Retroviral Nucleocapsid Protein and Assembly Symposium

第九届国际逆转录病毒核衣壳蛋白与组装研讨会

• 批准号: 8542099
• 负责人: Karin M Musier-Forsyth
• 金额: $ 0.45万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-15 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8542099
• 关键词: Acquired Immunodeficiency Syndrome; Amino Acid Motifs; Biological; Biotechnology; Chemicals; Collaborations; Complex; Conserved Sequence; DNA; Development; Dimerization; Discipline; Disease; Ensure; Environment; Exposure to; Female; Fingers; Funding; Gagging; Genome; Genomics; Glycoproteins; HIV-1; Human T-Cell Leukemia Viruses; Human T-lymphotropic virus 1; Indium; Individual; Infection; International; International Cooperation; Life Cycle Stages; Malignant Neoplasms; Modification; Molecular Chaperones; Names; Nucleic Acids; Nucleocapsid; Nucleocapsid Proteins; Nucleoproteins; Oncogenic; Outcome; Pathogenesis; Physical condensation; Play; Postdoctoral Fellow; Principal Investigator; Production; Proteins; Proviruses; RNA; RNA Viruses; Request for Applications; Research; Research Personnel; Research Training; Retroviridae; Reverse Transcription; Role; Science; Scientist; Students; Time; Transcription Initiation; Transfer RNA; Underrepresented Minority; Vaccines; Viral; Virion; Woman; Work; abstracting; combat; drug development; gag Gene Products; meetings; next generation; novel strategies; particle; public health relevance; scaffold; symposium; therapeutic target; viral DNA; viral RNA; young woman

DESCRIPTION (provided by applicant): The Retroviral Nucleocapsid (NC) Symposium (IRNCS) has historically focused on the biological role of the NC protein in HIV-1 and other retroviruses. Approximately 100-120 researchers worldwide have typically participated at this biennial symposium in an effort to generate a complete picture of the role of NC in retroviral pathogenesis. NC plays critical roles in (1) remodeling host and viral nucleic acids as a chaperone protein, (2) assembly and targeting the retroviral genomic RNA to new virus particles, and (3) protecting viral DNA and facilitating integration into host DNA. Some of these functions are performed by NC as part of the precursor Gag protein, and others are carried out by mature NCp7. More recent work shows that NC plays roles immediately following infection and in 2012, a role in retroviral restriction was discovered. NC therefore represents a suitable target for therapy. The symposium will provide a venue for researchers (principal investigators, postdoctoral fellows, students, research staff and representatives from biotechnology) to make progress in efforts to combat HIV-1/AIDS, as well as other retroviral diseases including cancer, by focusing on this central player in the viral lifecycle. The Retroviral NC Symposium has a long-standing record of research excellence, of promoting research collaborations, supporting young scientists, and including women and other individuals who have been traditionally underrepresented in science. This year, we will also emphasize the role of NC/Gag in assembly as the Retrovirus Assembly Meeting, held every 4 years since 2000 in Prague, will no longer be held. We are therefore renaming the conference as the "9th International Retroviral NC and Assembly Symposium" (IRNCAS).

描述（由申请人提供）：逆转录病毒核衣壳 (NC) 研讨会 (IRNCS) 历来关注 NC 蛋白在 HIV-1 和其他逆转录病毒中的生物学作用。全球大约有 100-120 名研究人员参加了这个两年一次的研讨会，以期全面了解 NC 在逆转录病毒发病机制中的作用。 NC 在以下方面发挥着关键作用：(1) 作为伴侣蛋白重塑宿主和病毒核酸；(2) 组装逆转录病毒基因组 RNA 并将其靶向新病毒颗粒；(3) 保护病毒 DNA 并促进与宿主 DNA 的整合。其中一些功能由作为前体 Gag 蛋白一部分的 NC 执行，其他功能由成熟的 NCp7 执行。最近的研究表明，NC 在感染后立即发挥作用，并于 2012 年发现了其在逆转录病毒限制中的作用。因此，NC 代表了合适的治疗靶点。研讨会将为研究人员（首席研究员、博士后研究员、学生、研究人员和生物技术代表）提供一个场所，通过重点关注这一问题，在抗击 HIV-1/艾滋病以及包括癌症在内的其他逆转录病毒疾病的努力中取得进展。病毒生命周期的核心参与者。北卡罗来纳州逆转录病毒研讨会在研究卓越、促进研究合作、支持年轻科学家以及包括女性和其他传统上在科学领域代表性不足的个人方面有着长期的记录。今年，我们还将强调 NC/Gag 在大会中的作用，因为自 2000 年以来每 4 年在布拉格举行一次的逆转录病毒大会将不再举行。因此，我们将会议更名为“第九届国际逆转录病毒数控和组装研讨会”(IRNCAS)。