A trial of Positively Smoke Free group therapy for HIV-infected smokers

对感染艾滋病毒的吸烟者进行积极无烟团体治疗的试验

• 批准号: 8708014
• 负责人: Jonathan Shuter
• 金额: $ 74.9万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8708014
• 关键词: AIDS-Related Opportunistic Infections; Abstinence; Address; Administrator; Alcohol consumption; Alcohol or Other Drugs use; Automobile Driving; Behavior Therapy; Cardiac; Caring; Cessation of life; Communities; Comorbidity; Cost Analysis; Counseling; Data; Development; Drug usage; Economics; Epidemic; Evaluation; Event; Feedback; Foundations; Funding; Future; Group Therapy; Guidelines; HIV; Health; Health Priorities; Highly Active Antiretroviral Therapy; Individual; Intention; International; Intervention; Knowledge; Learning; Life; Lung; Malignant Neoplasms; Malignant neoplasm of lung; Mediating; Mediator of activation protein; Meta-Analysis; Modality; Moods; Motivation; Nicotine; Odds Ratio; Outcome; Patients; Persons; Pilot Projects; Population; Prevalence; Provider; Published Comment; Publishing; Randomized; Randomized Controlled Trials; Recommendation; Relapse; Reporting; Research; Research Priority; Resources; Scientist; Self Efficacy; Services; Smoke; Smoker; Smoking; Smoking Cessation Intervention; Social Behavior; Social support; Societies; Telephone; Therapeutic community technique; Tobacco; Tobacco Use Cessation; United States National Institutes of Health; United States Public Health Service; Urban Population; Vulnerable Populations; Work; base; cigarette smoking; cohort; cost; evidence base; follow-up; health disparity; improved; insight; interest; meetings; nicotine replacement; peer; pilot trial; post intervention; programs; psychosocial; public health relevance; randomized trial; standard care; success; therapy design; treatment strategy; trend; working group

DESCRIPTION (provided by applicant): There are 1.1 million persons living with HIV (PLWH) in the US, 60% of them smoke cigarettes, and 75% of these are interested in quitting. Almost none are currently accessing smoking cessation interventions designed to meet their specific needs and concerns. Cigarette smoking is responsible for 24% of deaths among PLWH, and 30% of non-AIDS defining malignancies. It is driving the alarming rise in cardiac events and lung cancers in this highly vulnerable population. The lack of access to proven, effective, culturally appropriate tobacco cessation services represents a health disparity of the first order. The psychosocial profile of the PLWH-smoker community, characterized by high rates of psychiatric comorbidity, drug and alcohol use, and low levels of social support, suggests that achieving high cessation rates will be a great challenge. Positively Smoke Free (PSF) is an intensive, multisession, group cessation program specifically developed for PLWH smokers. A pilot study of PSF yielded promising results. This proposal aims (1) to perform a definitive efficacy study of PSF by comparing 6-month biochemically confirmed abstinence rates in subjects randomized to PSF vs. standard care in a cohort of 450 PLWH smokers, (2) to determine the sociobehavioral moderators and mediators associated with successful cessation, and (3) to complete a careful cost analysis of PSF in order to estimate the incremental cost per quit associated program participation. If PSF is proven to be effective it will establish a new treatment option for PLWH smokers. Determination of moderators and mediators of program success will provide insight into the mode of action of the intervention and will help guide the development of additional treatment strategies in the future. Finally, the cost analyses will provide critical information abut the feasibility of program dissemination and implementation.

描述（由申请人提供）：美国有110万人患有艾滋病毒（PLWH），其中60％的吸烟和75％的人有兴趣戒烟。目前，几乎没有一个人正在接受旨在满足其特定需求和疑虑的戒烟干预措施。 吸烟造成PLWH死亡的24％，而定义恶性肿瘤的非辅助剂中有30％。它正在推动这种高度脆弱的人群中心脏事件和肺癌的令人震惊的上升。缺乏获得经过验证，有效，适合文化的戒烟服务的机会代表了第一阶的健康差异。 PLWH-Smoker社区的心理社会形象为特征，其特征是精神病合并症，毒品和酒精的使用率很高，社会支持水平较低，这表明实现高停止率将是一个巨大的挑战。 无烟（PSF）是一项专门针对PLWH吸烟者开发的密集，多潜在的群体戒烟计划。 PSF的试点研究产生了令人鼓舞的结果。该提议的目的是（1）通过比较6个月的生物化学确认在450名PLWH吸烟者中随机与PSF与标准护理的受试者的禁欲，（2）通过比较Sociobehavioral的调节器和订购的订单，将PSF与Sociobehavioral Entiations的秩序相关联，并将（2）在PSF中进行比较，并将其与成功的成本分析相关联（3），以实现PSF和标准护理，并将其估算为成功的成本分析，以确定与Sociobehavioral的成本分析，并将其与（3）相关联，并将其与（3）进行比较，以进行PSF的确定效率研究（1）。相关的计划参与。 如果证明PSF有效，它将为PLWH吸烟者建立新的治疗选择。主持人和计划成功的调解人的确定将为干预措施的行动方式提供洞察力，并将有助于指导未来其他治疗策略的制定。最后，成本分析将提供关键信息，符合计划传播和实施的可行性。