FASEB SRC on Protein Lipidation, Signaling and Membrane Domains.

FASEB SRC 关于蛋白质脂化、信号传导和膜结构域。

• 批准号: 8977960
• 负责人: CHRISTINE A HRYCYNA
• 金额: $ 0.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8977960
• 关键词: Affect; Alzheimer' s Disease; American; Area; Award; Biochemistry; Biology; Biophysics; Cancer Biology; Cell physiology; Cellular biology; Clinical Medicine; Collaborations; Differentiation and Growth; Disease; Ensure; Equilibrium; Event; Exhibits; Fostering; Funding; Genetic; Lipids; Malignant Neoplasms; Membrane; Membrane Microdomains; Membrane Protein Traffic; Minority Groups; Obesity; Oral; Participant; Postdoctoral Fellow; Premature aging syndrome; Process; Proteins; Qualifying; Research; Research Personnel; Rivers; Role; Signal Transduction; Signaling Protein; Site; Societies; Training; Travel; Underrepresented Minority; Vermont; Woman; Work; abstracting; career development; cohort; drug discovery; effective therapy; graduate student; human disease; meetings; membrane synthesis; next generation; posters; public health relevance; symposium; trafficking

 DESCRIPTION (provided by applicant): The field of protein lipidation, signaling and membrane domains is an extremely active area of research as investigators seek to refine and expand our understanding of the consequences of protein-lipid interactions for cell signaling, growth and differentiation, and membrane synthesis and trafficking, and the role of these processes in human disease. We request funds to partially support the Federation of American Societies of Experimental Biology (FASEB) conference on "Protein Lipidation, Signaling and Membrane Domains", that will be held from July 19-24, 2015 in Saxtons River, Vermont. This meeting will highlight recent progress and provide a forum for critical discussions on these topics and promote interactions, idea-sharing, and collaborations between internationally leading researchers from diverse fields ranging from biophysics and biochemistry to cancer biology, genetics, clinical medicine and drug discovery. Lipid-modified proteins, signaling, and membrane domains represent distinct areas of research that are nonetheless closely intertwined. For example, many lipidated proteins regulate membrane synthesis and vesicular trafficking and intra- and inter- cellular signaling events. Moreover, lipidated proteins exhibit a strong yet dynamic interaction with membranes and their interaction with effector molecules and downstream signaling partners can be affected by shuttling in and out of membrane microdomains. Thus, investigators in these research areas benefit from and find synergy in discussions and collaborations initiated at this meeting. An equally important function of the meeting is to stimulate meaningful interactions between trainees including graduate students and postdoctoral fellows and established leaders in these fields. This objective is realistic given the small size of the conference (maximum 200 participants) and the requirement that speakers remain on-site throughout the meeting. We are also committed to fostering the career development of trainees. To this end, speakers chosen from submitted abstracts will present fifteen short talks, with at least two-thirds selected from this cohort. Furthermore, we propose to offer 20 travel awards of $500 to highly qualified graduate students and postdoctoral fellows and give a select group of them the opportunity to summarize the rationale, results, and importance of the work presented in their poster in a 2-minute oral presentation. In the selection process, we will ensure that the sessions are balanced with regard to the inclusion of women and underrepresented minority groups.

 描述（由申请人提供）：蛋白质脂化、信号传导和膜结构域领域是一个极其活跃的研究领域，因为研究人员试图完善和扩大我们对蛋白质-脂质相互作用对细胞信号传导、生长和分化的影响的理解、膜合成和运输，以及这些过程在人类疾病中的作用，我们请求资金部分支持美国实验生物学会联合会 (FASEB) 的“蛋白质脂化、信号传导和膜结构域”会议。将于 2015 年 7 月 19 日至 24 日在佛蒙特州萨克斯顿河举行，该会议将重点介绍最新进展，并为这些主题的批判性讨论提供一个论坛，并促进来自不同领域的国际领先研究人员之间的互动、思想共享和合作。生物物理学和生物化学到癌症生物学、遗传学、临床医学和药物发现代表了密切相关的不同研究领域，例如，许多脂质化蛋白质调节膜。此外，脂化蛋白表现出合成和囊泡运输以及细胞内和细胞间信号传导事件。 与膜的强烈而动态的相互作用以及它们与效应分子和下游信号传导伙伴的相互作用可能会受到膜微域进出的影响，因此，这些研究领域的研究人员受益于本次会议发起的讨论和合作，并发现了协同作用。会议的同等重要功能是促进包括研究生和博士后在内的学员与这些领域的知名领导者之间的有意义的互动，因为这一目标是现实的。 会议规模较小（最多 200 名与会者），并且要求演讲者在整个会议期间留在现场。为此，从提交的摘要中选出的演讲者将进行 15 场简短的演讲。 ，至少有三分之二的人从该队列中选择。 此外，我们建议 向高素质的研究生和博士后提供 20 个 500 美元的旅行奖励，并让他们中的一组有机会在评选中以 2 分钟的口头演讲总结其海报中展示的工作的基本原理、结果和重要性。在此过程中，我们将确保会议在包容妇女和代表性不足的少数群体方面保持平衡。