Role of brown adipose tissue (BAT) in energy balance

棕色脂肪组织（BAT）在能量平衡中的作用

• 批准号: 9148929
• 负责人: MARC L REITMAN
• 金额: $ 39.57万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9148929
• 关键词: Adipose tissue; Adrenergic Agonists; Adult; Body Weight; Brown Fat; Chronic; Comorbidity; Eating; Energy Metabolism; Goals; Homeostasis; Insulin Resistance; Metabolic; Mus; Obesity; Role; Temperature; Thermogenesis; Tissues; energy balance; glucose tolerance; improved; interest; metabolic rate

Progress in FY2015 includes the following: We studied chronic BAT stimulation with CL316243, a beta3-adrenergic agonist in mice at thermoneutrality (30C) and at a typical vivarium temperature (22C). Vehicle-treated control mice at 30C, compared to 22C, had reduced food intake, metabolic rate, and brown adipose activity, as well as increased adiposity due to the minimal need for adaptive thermogenesis at 30C. At both temperatures, CL316243 treatment increased brown adipose activation and energy expenditure and improved glucose tolerance. At 30C, CL316243 increased energy expenditure disproportionately to changes in food intake, thus reducing adiposity, while at 22C these changes were matched, yielding unchanged adiposity. We conclude that beta3-adrenergic agonist treatment can have beneficial metabolic effects in the absence of adiposity changes.

2015 财年的进展包括： 我们研究了 CL316243（一种 β3 肾上腺素能激动剂）在热中性 (30°C) 和典型动物饲养温度 (22°C) 下对小鼠的慢性 BAT 刺激。 与 22℃ 相比，在 30℃ 下进行媒介物处理的对照小鼠的食物摄入量、代谢率和棕色脂肪活性降低，并且由于 30℃ 下对适应性产热的需求最小，因此肥胖增加。在这两种温度下，CL316243 治疗均增加了棕色脂肪的活化和能量消耗，并改善了葡萄糖耐量。在 30°C 时，CL316243 增加的能量消耗与食物摄入量的变化不成比例，从而减少了肥胖，而在 22°C 时这些变化相匹配，产生未改变的肥胖。 我们得出的结论是，β3-肾上腺素能激动剂治疗在没有肥胖变化的情况下可以产生有益的代谢作用。