A Nanoparticle Respiratory Dose Sampler for Metal-Based Nanoparticles

金属基纳米粒子的纳米粒子呼吸剂量采样器

• 批准号: 8867045
• 负责人: Theresa Renee Anthony
• 金额: $ 35.41万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8867045
• 关键词: Nanoparticle; Respiratory; Dose; Sampler; Metal

DESCRIPTION (provided by applicant): Inhalation exposures of metal-based particles have been associated with severe adverse health outcomes from metal fume fever to cancer. Compared to the larger particles present in samples collected with typical industrial hygiene samplers (e.g., respirable), nanoparticles have substantially greater biological reactivity, deposition in the respiratory tract, and mobility in the body after depositing. Thus, freshly produced nanoparticles near fume sources may drive much of the observed adverse health effects, and respirable sampling may be insufficient to assess metal-based exposure risks. We have recently developed a novel personal sampler-the nanoparticle respiratory dose (NRD) sampler-and an associated analytical method that is easy to use, is inexpensive to analyze, and integrates into current personal exposure sampling strategies that can streamline the multi-step process for assessing titanium dioxide nanoparticle exposures. The work outlined in this application will expand the applicability of the NRD sampler and associated analytical methods to dramatically improve exposure assessment of a broad range of metal-based nanoparticle exposures in the workplace. With successful completion of the work proposed here, there will be many benefits, including an innovative, new sampler (Aim 1) coupled with associated analytical methods (Aim 2) applicable to assessing exposures to airborne metal-based particles. These new methodologies, validated through field studies (Aim 3), will be available for exposure assessments in routine industrial hygiene practice and in epidemiological study to better elucidate the adverse health effects that may be associated specifically with certain metal-based nanoparticle exposures. Consequently, our methods will have widespread use to assess exposures in the burgeoning field of nanotechnology or in more traditional occupational settings such as where welding occurs.

描述（由申请人提供）：金属颗粒的吸入暴露与从金属烟气发烧到癌症的严重不良健康结果有关。与使用典型的工业卫生采样器收集的样品中存在的较大颗粒（例如，可呼吸）相比，纳米颗粒具有更大的生物学反应性，呼吸道沉积和沉积后体内的迁移率。因此，在烟气来源附近生产的新鲜产生的纳米颗粒可能会造成许多观察到的不良健康影响，并且可呼吸的抽样可能不足以评估基于金属的暴露风险。我们最近开发了一种新型的个人抽样器 - 纳米颗粒呼吸剂量（NRD）采样器和一种易于使用的相关分析方法，可以廉价地进行分析，并将其集成到当前的个人暴露抽样策略中，这些策略可以简化用于评估二氧化二氧化二氧化二氧化二氧化二氧化二氧化二氧化钛的多步过程。本应用程序中概述的工作将扩展NRD采样器和相关的分析方法的适用性，以显着改善工作场所中广泛的金属纳米颗粒暴露的暴露评估。随着这里提出的工作的成功完成，将有许多好处，包括创新的新样本（AIM 1）以及相关的分析方法（AIM 2），可用于评估对机载金属粒子的暴露。通过现场研究（AIM 3）验证的这些新方法将用于常规工业卫生实践和流行病学研究中的暴露评估，以更好地阐明可能与某些基于金属的纳米颗粒暴露的不良健康效应。因此，我们的方法将广泛用于评估纳米技术新兴领域或更传统的职业环境（例如焊接发生的地方）中的暴露。