IGF::OT::IGF "HUMANIZED MOUSE MODELS FOR HIV THERAPEUTICS DEVELOPMENT"

IGF::OT::IGF“用于艾滋病治疗开发的人性化小鼠模型”

• 批准号: 9004371
• 负责人: Cheryl Stoddart
• 金额: $ 199.76万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-12-06 至 2015-12-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9004371
• 关键词: Animal Model; Clinical Research; Complement; Contracts; Data; Drug Evaluation; HIV; In Vitro; National Institute of Allergy and Infectious Disease; Pharmaceutical Preparations; Phase; Prevention strategy; Process; Research Personnel; Research Support; Resources; Therapeutic; Time; Translations; drug discovery; in vitro activity; in vivo; mouse model; nonhuman primate; programs; therapeutic development; tool development

This initiative will support NIAID DAIDS drug discovery and evaluation programs by providing a contract to evaluate potential HIV therapeutics in small animal models. The proposed mouse models provide a bridge from in vitro studies to more costly non-human primate studies and early-phase clinical studies.

该倡议将通过提供评估小动物模型中潜在的HIV治疗剂的合同来支持NIAID DAIDS的药物发现和评估计划。提出的小鼠模型提供了从体外研究到更昂贵的非人类灵长类动物研究和早期临床研究的桥梁。